Ocular diagnosis of Alzheimer's disease

  • US 7,297,326 B2
  • Filed: 11/18/2003
  • Issued: 11/20/2007
  • Est. Priority Date: 08/21/2000
  • Status: Active Grant
First Claim
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1. A method of diagnosing Alzheimer'"'"'s Disease or a predisposition thereto in a mammal, the method comprisinga) contacting an ocular tissue with a detectably-labeled compound that preferentially binds to an amyloid protein located in an ocular tissue, wherein the detectably-labeled compound is an amyloidophilic fluorescent dye;

  • b) allowing said compound to distribute into the lens; and

    c) imaging said ocular tissue,wherein an increase in binding of said compound to said ocular tissue compared to a normal control level of binding indicates that said mammal is suffering from or is at risk of developing Alzheimer'"'"'s Disease.

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