Drug/drug delivery systems for the prevention and treatment of vascular disease

  • US 7,300,662 B2
  • Filed: 04/21/2004
  • Issued: 11/27/2007
  • Est. Priority Date: 05/12/2000
  • Status: Active Grant
First Claim
Patent Images

1. A drug delivery device comprising:

  • an intraluminal stent;

    a biocompatible, nonerodible polymeric coating affixed to the intraluminal stent; and

    from about 64 μ

    g to about 197 μ

    g of rapamycin or a macrocyclic triene analog thereof that binds FKBP12 incorporated into the polymeric coating, wherein said device provides an in-stent late loss in diameter at 12 months following implantation in a human of less than about 0.5 mm, as measured by quantitative coronary angiography.

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