Heterocyclic inhibitors of ERK2 and uses thereof
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Abstract
Described herein are compounds that are useful as protein kinase inhibitors having the formula:
wherein A1, A2, TmR1, X, R2, R3, R9, R12, and R13 are as described in the specification. The compounds are especially useful as inhibitors of ERK2, Aurora2, GSK3, CDK2, AKT3, and ROCK protein kinases and for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, neurodegenerative disorders, inflammatory disorders, restenosis, diabetes, and cardiovascular disease.
63 Citations
22 Claims
- 1. A compound of general formula I:
Specification