Thrombolysis and chronic anticoagulation therapy
First Claim
1. A method for directing flow of anticoagulation medication, the method comprising:
- delivering at least one of a thrombolytic drug and an anticoagulation drug to a first tissue via an implanted treatment device that includesa catheter having a discharge portion positioned to deliver the at least one drug to the first tissue, anda lead having a stimulating electrode positioned to deliver an electrical pulse to a second tissue; and
limiting perfusion of the first tissue by delivering the electrical pulse to the second tissue via the stimulating electrode, wherein the electrical pulse is configured to constrict at least one arteriole supplying the first tissue.
2 Assignments
0 Petitions
Accused Products
Abstract
Thrombolytic and/or anticoagulation therapy of the present invention includes implantation of the discharge portion(s) of a catheter and, optionally, one or more electrodes on a lead, adjacent tissue(s) to be stimulated. Stimulation pulses, i.e., drug infusion pulses and optional electrical pulses, are supplied by a stimulator implanted remotely, and through the catheter or lead, which is tunneled subcutaneously between the stimulator and stimulation site. Stimulation sites include the coronary arteries, coronary veins, cerebral arteries, other blood vessels, chambers of the heart, mesenteric vessels, deep vessels of the leg, and other locations. Disclosed treatments include drugs used for chronic treatment and/or prevention of thromboembolic disease, for acute treatment of thromboembolic disease, for acute treatment of thrombosis, and combinations of these. The invention reduces or eliminates the incidence of thromboembolic disease and related morbidities, improve symptoms resulting from thromboembolic disease, and improve patient quality of life.
180 Citations
24 Claims
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1. A method for directing flow of anticoagulation medication, the method comprising:
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delivering at least one of a thrombolytic drug and an anticoagulation drug to a first tissue via an implanted treatment device that includes a catheter having a discharge portion positioned to deliver the at least one drug to the first tissue, and a lead having a stimulating electrode positioned to deliver an electrical pulse to a second tissue; and limiting perfusion of the first tissue by delivering the electrical pulse to the second tissue via the stimulating electrode, wherein the electrical pulse is configured to constrict at least one arteriole supplying the first tissue. - View Dependent Claims (2, 3, 4)
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5. A method for providing at least one of thrombolytic or anticoagulation therapy, comprising:
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providing a stimulator that generates a pulse in accordance with prescribed parameters; providing a catheter connected to the stimulator, which catheter includes a discharge portion; providing a lead connected to the stimulator, the lead including at least one electrode; implanting the catheter discharge portion adjacent to at least one tissue; implanting the stimulator at a location remote from the at least one tissue to be stimulated; implanting the lead adjacent to at least a second one tissue; delivering, via the catheter, pulses of at least one drug as at least one of thrombolytic or anticoagulation treatment to at least one tissue, which tissue comprises at least one of a coronary artery, a coronary vein, the coronary sinus, the left ventricle, the left atrium, the surface of the myocardium, a pulmonary vein, a carotid artery, the anterior cerebral artery, the middle cerebral artery, the posterior cerebral artery, the circle of Willis, a meningeal artery, the basilar artery, a pulmonary artery, the superior vena cava, the inferior vena cava, the right ventricle, the right atrium, the aorta, a common iliac vessel, an internal iliac vessel, an external iliac vessel, a femoral vessel, a renal vessel, the celiac trunk, the middle colic artery, a superior mesenteric vessel, an inferior mesenteric vessel, a deep vein of the leg, a vessel that influences coronary circulation, a vessel that influences cerebral circulation, a vessel that influences pulmonary circulation, a vessel that influences circulation of the lower limbs, and a vessel that influences visceral circulation; and limiting perfusion of the at least one tissue by delivering, via the lead, an electrical stimulating pulse to the at least one tissue, wherein said electrical pulse is configured to constrict at least one arteriole supplying the at least one tissue. - View Dependent Claims (6)
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7. A method for providing at least one of thrombolytic or anticoagulation therapy, comprising:
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providing a stimulator that includes a lead having at least one electrode to generate a pulse in accordance with prescribed parameters; providing a catheter connected to the stimulator, which catheter includes a discharge portion; implanting the catheter discharge portion adjacent to at least one tissue to be stimulated; implanting the stimulator at a location remote from the at least one tissue to be stimulated; chronically delivering via the catheter at least one drug as at least one of thrombolytic or anticoagulation treatment to at least one tissue; increasing delivery via the catheter of at least one drug to the at least one tissue during an acute emergency, which tissue comprises at least one of a coronary artery, a coronary vein, the coronary sinus, the left ventricle, the left atrium, the surface of the myocardium, a pulmonary vein, a carotid artery, the anterior cerebral artery, the middle cerebral artery, the posterior cerebral artery, the circle of Willis, a meningeal artery, the basilar artery, a pulmonary artery, the superior vena cava, the inferior vena cava, the right ventricle, the right atrium, the aorta, a common iliac vessel, an internal iliac vessel, an external iliac vessel, a femoral vessel, a renal vessel, the celiac trunk, the middle colic artery, a superior mesenteric vessel, an inferior mesenteric vessel, a deep vein of the leg, a vessel that influences coronary circulation, a vessel that influences cerebral circulation, a vessel that influences pulmonary circulation, a vessel that influences circulation of the lower limbs, and a vessel that influences visceral circulation; and limiting perfusion of the at least one tissue by delivering an electrical pulse to the at least one tissue, wherein said electrical pulse is configured to constrict at least one arteriole supplying the at least one tissue. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. An implantable system for providing at least one of thrombolytic or anticoagulation therapy, the system comprising:
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a power storage device; a stimulating electrode positionable to deliver an electrical pulse to a tissue; a memory storing stimulation parameters that describe an electrical pulse operable to modulate an arteriole lumen area of an arteriole by exciting activity in a neural or a muscular cell; an electrical signal generator to receive the stimulation parameters from the memory and to generate the electrical pulse deliverable by the stimulating electrode in accordance with the stimulation parameters, the electrical pulse generated using power drawn from the power storage device; means for chronically delivering a first drug for the thrombolytic or anticoagulation therapy to at least one tissue in accordance with prescribed parameters, the at least one tissue comprising at least one of a coronary artery, a coronary vein, the coronary sinus, the left ventricle, the left atrium, the surface of the myocardium, a pulmonary vein, a carotid artery, the anterior cerebral artery, the middle cerebral artery, the posterior cerebral artery, the circle of Willis, a meningeal artery, the basilar artery, a pulmonary artery, the superior vena cava, the inferior vena cava, the right ventricle, the right atrium, the aorta, a common iliac vessel, an internal iliac vessel, an external iliac vessel, a femoral vessel, a renal vessel, the celiac trunk, the middle colic artery, a superior mesenteric vessel, an inferior mesenteric vessel, a deep vein of the leg, a vessel that influences coronary circulation, a vessel that influences cerebral circulation, a vessel that influences pulmonary circulation, a vessel that influences circulation of the lower limbs, and a vessel that influences visceral circulation; and means for acutely delivering a second drug for the thrombolytic or anticoagulation therapy to the at least one tissue. - View Dependent Claims (22, 23, 24)
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Specification