Compositions for delivering bisphosphonates

• US 7,309,698 B2
• Filed: 03/01/2002
• Issued: 12/18/2007
• Est. Priority Date: 03/01/2001
• Status: Expired due to Fees

• Current Assignee: NOVO Nordisk North America Operations A/S (Novo Nordisk A/S)
• Original Assignee: Emisphere Technologies, Inc. (Novo Nordisk A/S)
• Inventors: Boyd, Maria Aurora P., Dinh, Steve
• Primary Examiner(s): Henley, III; Raymond J.
• Application Number:
  US10/468,622
• Publication Number:
  US 20040147484A1
• Time in Patent Office: 2,118 Days
• Field of Search: 514/108, 514/102, 514/2, 562/444
• US Class Current: 514/102
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/135 having aromatic rings , e.g. ketamine, nortriptyline methadone A61K31/137
• CPC Class Codes: A61K 31/195 having an amino group
• CPC Class Codes: A61K 31/66 Phosphorus compounds
• CPC Class Codes: A61K 31/663 Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
• CPC Class Codes: A61K 47/12 Carboxylic acids; Salts or anhydrides thereof
• CPC Class Codes: A61K 47/18 Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
• CPC Class Codes: A61K 47/183 Amino acids, e.g. glycine, EDTA or aspartame
• CPC Class Codes: A61K 9/0053 Mouth and digestive tract, i.e. intraoral and peroral administration rectal administration A61K9/0031
• CPC Class Codes: A61P 19/08 for bone diseases, e.g. rachitism, Paget's disease
• CPC Class Codes: A61P 19/10 for osteoporosis
• CPC Class Codes: C07C 235/60 having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
• CPC Class Codes: C07C 235/64 having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
• CPC Class Codes: C07C 59/68 the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
• CPC Class Codes: C07C 59/90 containing singly bound oxygen-containing groups

Abstract

Compounds and compositions for the delivery of bisphosphonates are provided. Methods of preparation, administration and treatment are provided as well.

Claims

1. A composition comprising:

(A) alendronate; and

(B) at least one compound selected from

2. The composition of claim 1 wherein (B) is

3. The composition of claim 2 wherein (B) is the sodium salt of compound 1.

4. The composition of claim 1 wherein (B) is

5. The composition of claim 1 wherein (B) is

6. The composition of claim 1 wherein (B) is

7. The composition of claim 1 wherein (B) is

8. The composition of claim 1 wherein (B) is

9. The composition of claim 1 wherein (B) is

10. The composition of claim 1 wherein (B) is

11. A composition comprising:

(A) ibandronate; and

(B) at least one compound selected from

12. The composition of claim 11 wherein (B) is

13. The composition of claim 12 wherein (B) is the sodium salt of compound 1.

14. The composition of claim 11 wherein (B) is

15. The composition of claim 11 wherein (B) is

16. The composition of claim 11 wherein (B) is

17. The composition of claim 11 wherein (B) is

18. The composition of claim 11 wherein (B) is

19. The composition of claim 11 wherein (B) is

20. The composition of claim 11 wherein (B) is

21. A composition comprising:

(A) risedronate; and

(B) at least one compound selected from

22. The composition of claim 21 wherein (B) is

23. The composition of claim 22 wherein (B) is the sodium salt of compound 1.

24. The composition of claim 21 wherein (B) is

25. The composition of claim 21 wherein (B) is

26. The composition of claim 21 wherein (B) is

27. The composition of claim 21 wherein (B) is

28. The composition of claim 21 wherein (B) is

29. The composition of claim 21 wherein (B) is

30. The composition of claim 21 wherein (B) is

31. A composition comprising:

(A) zoledronate; and

(B) at least one compound selected from

32. The composition of claim 31 wherein (B) is

33. The composition of claim 32 wherein (B) is the sodium salt of compound 1.

34. The composition of claim 31 wherein (B) is

35. The composition of claim 31 wherein (B) is

36. The composition of claim 31 wherein (B) is

37. The composition of claim 31 wherein (B) is

38. The composition of claim 31 wherein (B) is

39. The composition of claim 31 wherein (B) is

40. The composition of claim 31 wherein (B) is