Identification of the gene and mutation responsible for progressive rod-cone degeneration in dog and a method for testing same

  • US 7,312,037 B2
  • Filed: 06/21/2005
  • Issued: 12/25/2007
  • Est. Priority Date: 06/21/2004
  • Status: Active Grant
First Claim
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1. A method for identifying a dog as genetically normal, as a carrier of, or as predisposed to progressive rod cone degeneration comprising:

  • a) obtaining a biological sample comprising nucleic acids from the dog; and

    b) testing the biological sample comprising nucleic acids for a G to A transversion in the F04 gene at nucleotide position 1298 of SEQ ID NO;

    1, wherein the G to A transversion in one allele is indicative of a carrier of progressive rod-cone degeneration, the G to A transversion in both alleles is indicative of a dog affected with or predisposed to progressive rod-cone degeneration, and the absence of the G to A transversion is indicative of a genetically normal dog.

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