Device and method for non-invasive optical measurements

• US 7,313,425 B2
• Filed: 07/08/2004
• Issued: 12/25/2007
• Est. Priority Date: 07/08/2004
• Status: Active Grant

• Current Assignee: OrSense Ltd.
• Original Assignee: OrSense Ltd.
• Inventors: Fine, Ilya, Finarov, Alexander
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US10/885,885
• Publication Number:
  US 20060009685A1
• Time in Patent Office: 1,265 Days
• Field of Search: 600/310, 600/316, 600/322, 600/323, 600/335, 600/344
• US Class Current: 600/310
• CPC Class Codes: A61B 5/0053 by applying pressure, e.g. compression, indentation, palpation, grasping, gauging
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/6826 Finger
• CPC Class Codes: A61B 5/6838 Clamps or clips

Abstract

An optical measurement device and method are presented for use in non-invasive measurements on a patient'"'"'s body. The device comprises an illumination assembly configured and operable to generate illuminating light of a predetermined wavelength range; a detection assembly; and a light directing assembly. The detection assembly comprises a first detector unit for detecting a first light signal transmitted through an illuminated body portion and generating first measured data indicative of the detected transmitted light, and a second detector unit for detecting a second light signal reflected from the illuminated body portion and generating second measured data indicative of the detected reflected light. The light directing assembly comprises a light diffuser for scattering back light incident thereto, to thereby direct the illuminating light or the light coming from the body portion back towards the body portion. This technique provides for increasing the amount of light reaching a region of interest inside the body portion and maximizing homogeneity of the first and second detected light signals.

Claims

1. An optical measurement device for use in non-invasive measurements on a patient'"'"'s body, the device comprising:

an illumination assembly configured and operable to generate illuminating light of a predetermined wavelength range;

a detection assembly configured and operable to concurrently provide transmission-mode and reflection-mode of light detection, the detection assembly comprising a first transmission-mode detector unit configured for detecting a first light signal indicative of the transmission of the illuminating light in the predetermined wavelength range through an illuminated body portion and generating first measured data indicative of the detected transmitted light, and a second reflection-mode detector unit operating simultaneously with said first detector and configured for detecting a second light signal indicative of the reflection of the illuminating light in the predetermined wavelength range from the illuminated body portion and generating second measured data indicative of the detected reflected light; and

a light directing assembly comprising a light diffuser for scattering back light incident thereto, the light diffuser being oriented to redirect at least one of the illuminating, transmitted and reflected light components back towards the illuminated body portion to thereby cause further interaction of the redirected light with the body portion, and allow detection of the transmitted and reflected light components by said first and second detection units, thereby increasing amount of light reaching a region of interest inside the body portion and thus maximizing homogeneity of the first and second detected light signals.

2. The device of claim 1, wherein the light diffuser is located adjacent to the illumination assembly and, such that when the device is applied to the patient'"'"'s body, the light diffuser extends along at least a part of the body portion at the illuminating side thereof.

3. The device of claim 2, wherein the diffuser is formed with an optical window for allowing passage of light from the illumination assembly towards the body portion.

4. The device of claim 3, wherein the diffuser has an additional optical window for allowing light passage from the body portion to the second detector unit.

5. The device of claim 1, wherein the light diffuser has at least one optical window for allowing light passage therethrough.

6. The device of claim 1, wherein the diffuser is made of a semi-transparent material, capable of diffusing visible and near-infrared light spectra.

7. The device of claim 1, wherein the diffuser is configured such that an attenuation coefficient and spatial distribution of diffused light is a very weak function of wavelength in said predetermined spectral rage.

8. The device of claim 1, wherein a minimal size for the diffuser is such as to ensure that majority of the body surface provides efficient return of reflected light to the region of interest in the body.

9. The device of claim 1, wherein the diffuser has a minimal size of about 48 mm².

10. The device of claim 1, wherein the detector unit includes a matrix of light detectors.

11. The device of claim 1, wherein the diffuser is mounted on a support arrangement supporting at least one of the illumination and detection assemblies.

12. The device of claim 1, wherein the diffuser is an elastic cover configured to wrap at least a part of the body portion under measurements.

13. The device of claim 12, wherein the diffuser has at least one optical window for allowing light passage therethrough.

14. The device of claim 1, wherein the diffuser is a disposable elastic cover configured to wrap at least a part of the body portion under measurements.

15. The device of claim 1, comprising a pressurizing assembly operable for applying an over-systolic pressure to the patient'"'"'s body so as to create a condition of artificial blood kinetics in the region of interest and maintain this condition for a certain time period.

16. The device of claim 15, wherein said pressurizing assembly is operable to apply a secondary controllably varying pressure to the body within the region of interest, so as to alter said condition of artificial blood kinetics over a predetermined time interval within said certain time period, thereby to modulate scattering properties of blood.

17. The device of claim 1, wherein the illumination assembly comprises at least one light emitting element.

18. The device of claim 1, wherein the illumination assembly comprises a matrix of light emitting elements generating light of different wavelengths.

19. The device of claim 1, configured as a clip member for enclosing the body portion between its upper and lower arms, one of the upper and lower arms carrying the illumination assembly, the diffuser and the second detector unit, and the other arm carrying the first detector unit.

20. The device of claim 19, wherein the diffuser extends along at least a part of an inner surface of said arm of the clip member.

21. The device of claim 20, wherein the diffuser is located between the illumination assembly and the body portion, and is formed with an optical window for allowing passage of light from the illumination assembly to the body portion.

22. The device of claim 21, wherein the diffuser is located between the body portion and the second detector unit, and is formed with an optical window allowing light passage therethrough from the body portion to the second detector unit.

23. The device of claim 21, wherein the diffuser is located between the body portion and the second detector unit, and is formed with an additional optical window allowing light passage therethrough from the body portion to the second detector unit.

24. The device of claim 19, configured for measuring in a patient'"'"'s finger, said clip member enclosing the finger between its upper and lower arms.

25. The device of claim 1, comprising a clip member for enclosing the body portion between its upper and lower arms, one of the upper and lower arms carrying the illumination assembly and the second detector unit, and the other arm carrying the first detector unit, the diffuser being an elastic cover configured to wrap at least a part of the body potion under measurements, such that when the device is put in operation, the diffuser is located between the body portion and each of said arms of the clip member.

26. The device of claim 25, wherein the diffuser has at least one optical window to allow for the light passage therethrough.

27. The device of claim 25, configured for measuring in a patient'"'"'s finger, said clip member enclosing the finger between its upper and lower arms.

28. The device of claim 1, configured for measuring in a patient'"'"'s finger.

29. The device of claim 28, having a housing formed by two substantially U-shaped portions configured for enclosing and holding a portion of the patient'"'"'s finger therebetween.

30. The device of claim 29, wherein one of the U-shaped portions carries the illumination assembly, the diffuser and the second detector unit, and the other of said portion carries the first detector unit.

31. The device of claim 29, wherein one of the U-shaped portions carries the illumination assembly and the second detector unit, and the other of said portion carries the first detector unit.

32. The device of claim 31, wherein the diffuser is an elastic cover configured to wrap at least a part of the patient'"'"'s finger.

33. The device of claim 32, wherein the diffuser has at least one optical window for allowing light passage therethrough.

34. The device of claim 31, wherein the diffuser is a disposable elastic cover configured to wrap at least a part of the patient'"'"'s finger.

35. The device of claim 28, comprising a pressurizing assembly associated with one of the U-shaped portions and operable for applying an over-systolic pressure to the fleshy medium so as to create a condition of artificial blood kinetics in the fleshy medium and maintain this condition for a certain time period.

36. The device of claim 35, wherein said pressurizing assembly is operable to apply a secondary controllably varying over-systolic pressure to the body portion, so as to alter said condition of artificial blood kinetics over a predetermined time interval within said certain time period, to thereby modulate scattering properties of blood.

37. The device of claim 35, wherein the pressurizing assembly comprises an air cushion extending along at least a part of an inner surface of the housing.

38. The device of claim 37, wherein at least a part of said cushion is made of a light diffusing material, thereby presenting said diffuser.

39. An optical measurement device for non-invasive measurements on a patient'"'"'s finger, the device comprising:

a ring-like housing for enclosing a portion of the finger therein;

an illumination assembly mounted on said housing, the illumination assembly being configured and operable to direct illuminating light of a predetermined wavelength range towards a portion of the finger under measurements;

a detection assembly mounted on said housing, the detection assembly being configured and operable to concurrently provide transmission-mode and reflection-mode of light detection, the detection assembly comprising a first transmission-mode detector unit accommodated substantially opposite the illumination assembly for detecting a first light signal indicative of the transmission of the illuminating light in the predetermined wavelength range through the finger portion in the predetermined wavelength range and generating first measured data indicative of the detected transmitted light, and a second reflection-mode detector unit operating simultaneously with said first detector and accommodated for detecting a second light signal indicative of the reflection of the illuminating light in the predetermined wavelength range from the finger portion and generating second measured data indicative of the detected reflected light;

a light diffuser accommodated for receiving light reflected from the finger portion and re-directing the received light back towards the finger portion to thereby cause further interaction of said light with said finger portion and allowing detection of the reflected light by said second reflection-mode detection unit, thereby increasing amount of light reaching a region of interest inside the finger portion and thus maximizing homogeneity of the first and second detected light signals.

40. A method for use in non-invasive optical measurements on a patient'"'"'s body utilizing illumination of a region of interest inside the body portion by illuminating light of a predetermined wavelength range and detection of light response of the region of interest, the method comprising:

collecting at least a part of light coming from the illuminated body portion and re-directing at least a part of the collected light back to the body portion to thereby cause further interaction of said light with the body portion, light coming from the body portion including transmission of the illuminating light through the illuminated body portion and reflection of the illuminating light from the illuminated body portion;

concurrently detecting first and second light signals which are indicative of, respectively, the light transmitted through the body portion in the predetermined wavelength range and the light reflected from said body portion, and generating first measured data indicative of the detected transmitted light second measured data indicative of the detected reflected light; and

analyzing the first and second measured data and generating at least one parameter related to the blood of said patient'"'"'s body;

the method providing for increasing amount of light reaching the region of interest inside the body portion, and for maximizing homogeneity of the first and second detected light signals.

41. The method of claim 40, wherein said collected light coming from the body portion is light reflected therefrom.

42. The method of claim 41, wherein said collecting of the reflected light and directing at least the part thereof back to the body portion comprises locating a light diffuser in an optical path of the light reflected from the body portion.

43. The method of claim 40, wherein said collecting of the light coming from the body portion and directing at least the part of the collected light back to the body portion comprises locating a light diffuser in an optical path of the light coming from the body portion.

44. The method of claim 43, wherein the diffuser is made of a semi-transparent material, capable of diffusing visible and near-infrared light spectra.

45. The method of claim 43, wherein the diffuser is configured such that an attenuation coefficient and spatial distribution of diffused light is a very weak function of wavelength in an operating spectral rage.

46. The method of claim 43, comprising selecting a minimal size for the diffuser such as to ensure that majority of the body surface provides efficient return of reflected light to the region of interest in the body.