Angioplasty stents

• US 7,344,563 B2
• Filed: 03/01/2004
• Issued: 03/18/2008
• Est. Priority Date: 07/20/2001
• Status: Expired due to Term

• Current Assignee: CID S.p.A (Alvimedica ApS)
• Original Assignee: Sorin Biomedica Cardio Srl (LivaNova Plc)
• Inventors: Gaschino, Paolo, Vallana, Franco, Curcio, Maria, Rolando, Giovanni
• Primary Examiner(s): GHERBI, SUZETTE JAIME J
• Application Number:
  US10/790,649
• Publication Number:
  US 20040172124A1
• Time in Patent Office: 1,478 Days
• Field of Search: 623 111- 148
• US Class Current: 623/1.42
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2002/91541 Adjacent bands are arranged out of phase
• CPC Class Codes: A61F 2002/9155 Adjacent bands being connected to each other
• CPC Class Codes: A61F 2002/91583 by a bridge, whereby at least one of its ends is connected along the length of a strut between two consecutive apices within a band
• CPC Class Codes: A61F 2230/0054 V-shaped
• CPC Class Codes: A61F 2250/0068 the pharmaceutical product being in a reservoir

Abstract

A stent for use at an implant site in a vessel having recesses containing one or more active agents. The stent is a tubular body having a plurality of sinusoidal shaped annular elements and connection elements. The recesses are formed so as to leave substantially unaltered the bending moments of these elements. The recesses may be continuous or discontinuous and may be distributed uniformly or nonuniformly.

Claims

1. A stent for use at an implant site in a vessel comprising a radially expandable tubular body and an active agent for treatment of the implant site, the tubular body having an interior surface and an exterior surface, the tubular body including a plurality of sinusoidal shaped annular elements and a plurality of connection elements, each annular element being connected to at least one other annular element by at least two connection elements, each connection element having a first end connected to an annular element at a zero point of the sinusoidal shape of the annular element and a second end connected to an adjacent annular element at a zero point of the sinusoidal shape of the adjacent annular element, the tubular body having a plurality of recesses, the active agent being contained within the recesses, the recesses conferring on the elements where they are positioned a hollowed sectional profile of which the recesses occupy a portion of the area of the sectional profile, the geometry of the recesses being such that bending moments of inertia of the elements containing the recesses are not substantially reduced.

2. The stent of claim 1 wherein the plurality of recesses are on the exterior surface of the stent.

3. The stent of claim 1 wherein the hollowed sectional profile of the recesses ranges from 10% to 60% of the area of the sectional profile.

4. The stent of claim 1 wherein the hollowed sectional profile of the recesses ranges from 20% to 50% of the area of the sectional profile.

5. The stent of claim 4 wherein the stent has a longitudinal axis and wherein the active agent contained within the recesses is present in a non-uniform distribution along the longitudinal axis of the stent.

6. The stent of claim 1 wherein the hollowed sectional profile of the recesses is not less than 30% of the area of the sectional profile.

7. The stent of claim 1 wherein the hollowed sectional profile of the recesses has a C-shaped profile.

8. The stent of claim 1 wherein the stent has a longitudinal axis and wherein the hollowed sectional profile of the recesses has a rectangular profile, a longer dimension of the rectangular profile extending in a direction tangential to the longitudinal axis of the stent.

9. The stent of claim 1 wherein the stent has a longitudinal axis and wherein the hollowed sectional profile of the recesses has a rectangular profile, a longer dimension of the rectangular profile extending in a direction radial to the longitudinal axis of stent.

10. The stent of claim 1 wherein the hollowed sectional profile of the recesses has a substantially U-shaped profile.

11. The stent of claim 1 wherein the hollowed sectional profile of the recesses has a substantially V-shaped profile.

12. The stent of claim 1 wherein the hollowed sectional profile of the recesses has undercut areas.

13. The stent of claim 1 wherein the plurality of recesses is substantially discontinuous.

14. The stent of claim 1 wherein each recess of the plurality of recesses has a substantially well-shaped configuration.

15. The stent of claim 1 wherein the active agent comprises at least two different active agents.

16. A stent for use at an implant site in a vessel comprising a radially expandable tubular body and an active agent for treatment of the implant site, the tubular body having an interior surface and an exterior surface, the tubular body including a plurality of sinusoidal shaped annular elements and a plurality of connection elements, each annular element being connected to at least one other annular element by a plurality of connection elements, each connection element having a curved portion positioned between first and second rectilinear portions, each annular element having a rectilinear portion and a curved portion, the exterior surface of the tubular body having a plurality of recesses positioned only in the rectilinear portions, the active agent being contained within the recesses, the recesses conferring on the rectilinear portion where they are positioned a hollowed sectional profile of which the recesses occupy from 10% to 60% of the area of the sectional profile, the geometry of the recesses being such that bending moments of inertia of the portions containing the recesses are not substantially reduced.

17. The stent of claim 16 wherein the hollowed sectional profile of the recesses ranges from 20% to 50% of the area of the sectional profile.

18. The stent of claim 16 wherein the hollowed sectional profile of the recesses is not less than 30% of the area of the sectional profile.

19. The stent of claim 16 wherein the hollowed sectional profile of the recesses has a C-shaped profile.

20. The stent of claim 16 further wherein the stent has a longitudinal axis and wherein the hollowed sectional profile of the recesses has a rectangular profile, a longer dimension of the rectangular profile extending in a direction tangential to the longitudinal axis of the stent.

21. The stent of claim 16 wherein the stent has a longitudinal axis and wherein the hollowed sectional profile of the recesses has a rectangular profile, a longer dimension of the rectangular profile extending in a direction radial to the longitudinal axis of stent.

22. The stent of claim 16 wherein the hollowed sectional profile of the recesses has a substantially U-shaped profile.

23. The stent of claim 16 wherein the hollowed sectional profile of the recesses has a substantially V-shaped profile.

24. The stent of claim 16 wherein the hollowed sectional profile of the recesses has undercut areas.

25. The stent of claim 16 wherein the plurality of recesses is substantially discontinuous on the exterior surface of the rectilinear portions of the stent.

26. The stent of claim 16 wherein each recess of the plurality of recesses has a substantially well-shaped configuration.

27. The stent of claim 16 wherein the active agent comprises at least two different active agents.

28. The stent of claim 16 further wherein the stent has a longitudinal axis and wherein the active agent contained within the recesses is present in a non-uniform distribution along the longitudinal axis of the stent.

29. A stent for use at an implant site in a vessel comprising a radially expandable tubular body and an active agent for treatment of the implant site, the tubular body having an interior surface and an exterior surface, the tubular body including a plurality of annular elements and a plurality of connection elements, each connection element having a curved portion positioned between first and second rectilinear portions, the annular elements and connection elements having portions subject to stress during expansion or use of the stent and portions not subject to stress during expansion or use of the stent, each annular element being connected to at least one other annular element by a plurality of connection elements, the tubular body having a plurality of recesses positioned only in the portions that are not subject to stress during expansion or use of the stent, the active agent being contained within the recesses, the recesses conferring on the portions where they are positioned a hollowed sectional profile of which the recesses occupy a substantial portion of the area of the sectional profile, the geometry of the recesses being such that the characteristic of bending strength of the portions containing the recesses is not substantially reduced.

30. The stent of claim 29 wherein the hollowed sectional profile of the recesses is not less than 30% of the area of the sectional profile.

31. A stent for use at an implant site in a vessel comprising a radially expandable tubular body and an active agent for treatment of the implant site, the tubular body having an interior surface and an exterior surface, the tubular body including a plurality of annular elements and a plurality of connection elements, each connection element having a curved portion positioned between first and second rectilinear portions, the annular elements and connection elements having portions subject to deformation during expansion or use of the stent and portions not subject to deformation during expansion or use of the stent, each annular element being connected to at least one other annular element by a plurality of connection elements, the tubular body having a plurality of recesses positioned only in the portions that are not subject to deformation during expansion or use of the stent, the active agent being contained within the recesses, the recesses conferring on the portions where they are positioned a hollowed sectional profile of which the recesses occupy a substantial portion of the area of the sectional profile, the geometry of the recesses being such that the characteristic of bending strength of the portions containing the recesses is not substantially reduced.