Breath aerosol management and collection system

• US 7,364,553 B2
• Filed: 12/22/2003
• Issued: 04/29/2008
• Est. Priority Date: 12/20/2002
• Status: Expired due to Fees

• Current Assignee: Amidex Incorporated
• Original Assignee: Amidex Incorporated
• Inventors: Wiernicki, Michael V, Paz, Frederick Mark, Howson, David
• Primary Examiner(s): Nasser. Jr.; Robert L.
• Assistant Examiner(s): Toth; Karen E
• Application Number:
  US10/745,331
• Publication Number:
  US 20050137491A1
• Time in Patent Office: 1,590 Days
• Field of Search: 600529-543
• US Class Current: 600/543
• CPC Class Codes: A61B 5/0836 Measuring rate of CO2 production
• CPC Class Codes: A61B 5/087 Measuring breath flow
• CPC Class Codes: A61B 5/0878 using temperature sensing means
• CPC Class Codes: A61B 5/097 Devices for facilitating collection of breath or for directing breath into or through measuring devices

Abstract

Aerosol collectors 10, 120 include pre-collection filters 100, 126, aerosol collection chambers 30, 130, and other exhaled breath conditioning and control features for providing not only accurate and efficient, but also reliable and reproducible aerosol collections that can be used in standardizations and can be compared in meaningful ways to other exhaled breath aerosol collections from the same test subject and from different test subjects. The aerosol collector 10 example includes electrostatic collection components 34, 40, and the aerosol collector 120 includes nucleating condensation components 168, 172 and vortex collection components 132, 138. Both include analyte extraction apparatus 50, 124.

Claims

1. Aerosol collector apparatus for collecting aerosol from exhaled breath of a test subject, comprising:

an aerosol collection chamber with a collection surface charged with an electrostatic voltage for collecting aerosol particles from exhaled breath, wherein the aerosol particles are ionized after being exhaled;

a conduit for channeling the exhaled breath from the test subject to the aerosol collection chamber;

an ionizer system in the conduit for ionizing the aerosol particles in the exhaled breath,

an extractor system to remove the aerosol particles from the collection surface for analysis; and

a pre-collection filter, wherein the pre-collection filter is an ionizing filter connected in fluid-flow relation to the conduit, and the pre-collection filter is positioned in close enough proximity to the aerosol collection chamber to filter ambient aerosols and prevent ambient aerosols from being inhaled by the test subject.

2. The aerosol collector apparatus of claim 1, including at least one flow meter positioned to measure flow rate of the exhaled breath through the chamber.

3. The aerosol collector apparatus of claim 1, including a wiper in the extractor system, which is positioned slideably on the collection surface for wiping the collected aerosol particles off the collector surface.

4. The aerosol collector apparatus of claim 1, including an exhaust outlet in fluid-flow relation to the collection chamber to remove exhaled breath stripped of aerosol particles.

5. The aerosol collector apparatus of claim 4, including a vacuum source connected to the exhaust outlet.

6. The aerosol collector apparatus of claim 1, including a mouthpiece connected in fluid-flow relation to the conduit.

7. The aerosol collector apparatus of claim 6, including an artifact trap positioned in the conduit between the mouthpiece and the collection chamber.

8. The aerosol collector apparatus of claim 6, including a mouthpiece in the conduit upstream from the collection surface.

9. The aerosol collector apparatus of claim 1, including operable valves so that during inhalation of a breath by the test subject through the mouthpiece the inhalation breath flows through the pre-collection filter, and so that during exhalation of breath by the test subject the exhalation breath flows through the collection chamber.

10. The aerosol collector apparatus of claim 9, including a flow meter connected in fluid-flow relation to the collection chamber to produce flow rate measurements of exhaled breath, and wherein a control means utilizes the flow rate measurements of the exhaled breath to partially open or partially close operable valves to control flow rate of exhaled breath.

11. The aerosol collector apparatus of claim 1 wherein the ionizer system is positioned in a conduit upstream from the collection surface.

12. The aerosol collector apparatus of claim 11, wherein the ionizer system is positioned in the conduit downstream of the mouthpiece.

13. The aerosol collector apparatus of claim 12, including a wire mesh positioned in the conduit between the ionizer assembly and the mouthpiece.

14. Aerosol collector apparatus for collecting aerosol from exhaled breath of a test subject, comprising:

an aerosol collection chamber in fluid-flow relation to a vortex generator for collecting aerosol particles from exhaled breath, wherein the aerosol particles are subject to nucleation condensation after being exhaled;

a conduit for channeling the exhaled breath from the test subject to the aerosol collection chamber;

an extractor system to remove the aerosol particles from the collection surface for analysis; and

a pre-collection filter, wherein the pre-collection filter is an ionizing filter connected in fluid-flow relation to the collection chamber, and wherein the pre-collection filter is positioned in close enough proximity to the aerosol collection chamber to filter ambient aerosols and prevent them from being inhaled by the test subject.

15. The aerosol collector apparatus of claim 14, wherein the collection chamber is a figure of revolution with a longitudinal axis, and wherein the vortex generator includes a tangential intersection of the conduit with the collection chamber.

16. The aerosol collection apparatus of claim 15, wherein the vortex generator also includes a flow constriction at the intersection of the conduit with the collection chamber in a position to direct the exhaled breath through the flow constriction to produce a jet stream that is laterally offset from the longitudinal axis of the collection chamber.

17. The aerosol collection apparatus of claim 16, wherein the flow construction includes a nozzle.

18. The aerosol collector apparatus of claim 14, wherein the collection surface is temperature controlled to maintain the temperature of the collection surface within a predetermined temperature range.

19. The aerosol collector apparatus of claim 14, including at least one flow meter positioned to measure flow rate of the exhaled breath through the chamber.

20. The aerosol collector apparatus of claim 14, including a wiper in the extractor system, which is positioned slideably on the collection surface for wiping the collected aerosol particles off the collector surface.

21. The aerosol collector apparatus of claim 14, including an exhaust outlet in fluid-flow relation to the collection chamber to remove exhaled breath stripped of aerosol particles.

22. The aerosol collector apparatus of claim 21, including a vacuum source connected to the exhaust outlet.

23. The aerosol collector apparatus of claim 14, including a mouthpiece connected in fluid-flow relation to the collection chamber.

24. The aerosol collector apparatus of claim 23, including an artifact trap positioned in the conduit between the mouthpiece and the collection chamber.

25. The aerosol collector apparatus of claim 23, including a mouthpiece in the conduit upstream from the collection surface.

26. The aerosol collector apparatus of claim 25, including a wire mesh positioned in the conduit between the ionizer assembly and the mouthpiece.

27. The aerosol collector apparatus of claim 14, including operable valves so that during inhalation of a breath by the test subject through the mouthpiece the inhalation breath flows through the pre-collection filter, and so that during exhalation of breath by the test subject the exhalation breath flows through the collection chamber.

28. The aerosol collector apparatus of claim 14, including a flow meter connected in fluid-flow relation to the collection chamber to produce flow rate measurements of exhaled breath, and wherein a control means utilizes the flow rate measurements of the exhaled breath to partially open or partially close operable valves to control flow rate of exhaled breath.

29. Aerosol collector apparatus for collecting aerosol from exhaled breath of a test subject, comprising:

an aerosol collection chamber with a collection surface for collecting aerosol particles from exhaled breath, wherein the exhaled aerosol particles are subjected to an electrostatic, centrifugal, thermophoretic, magnetic, gravitational, inertia or aerodynamic force to capture substantially all aerosol materials as small as 10 nanometers in mean equivalent diameter for analysis;

a conduit for channeling the exhaled breath from the test subject to the aerosol collection chamber;

an extractor system to remove the aerosol particles from the collection surface for analysis;

a pre-collection filter positioned in close enough proximity to the aerosol collection chamber to filter ambient aerosols and prevent ambient aerosols from being inhaled by the test subject, and

at least one flow meter positioned to measure flow rate of the exhaled breath through the collection chamber wherein a control means utilizes the flow rate measurements of the exhaled breath to partially open or partially close operable valves to control flow rate of exhaled breath.

30. The aerosol collector apparatus of claim 29 wherein the collection chamber includes an ionizer system.

31. The aerosol collector apparatus of claim 29 wherein the collection chamber includes a vortex generator.

32. The aerosol collector apparatus of claim 29 wherein the pre-collection filter is an ionizing filter.