Method and apparatus for the diagnosis of glaucoma and other visual disorders
First Claim
Patent Images
1. A method of assessing eye function, comprising:
- (a) providing an image area in which images can be presented to the eye, and in which the luminance of any point in the image area over the desired field of view under test can be defined at least as accurately as the desired accuracy of a retinal map to be obtained;
(b) forming a fixation image;
(c) presenting a stimulus to the eye at a location within the image area spaced from the fixation image;
(d) detecting a saccade triggered by said stimulus and immediately removing the original fixation image and creating a new fixation image at said location;
(e) recording the timing and magnitude of the saccade and the subsequent fixation;
(f) repeating steps (c) to (e), and(g) comparing the results with a database of typical eye responses,wherein each of the fixation images is an animated fixation image comprising a substantially stationary central region comprising at least 20% of the fixation image and a mobile perimeter defined such that the perimeter is greater than 3% of the arc of vision of the test subject in diameter.
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Abstract
A subject (12) observes an image on a display (10). A control (18) produces a fixation image at a selected position in the display, followed by a stimulus spaced from the fixation image. An eye position sensor (14) detects a saccade movement towards the stimulus. The stimulus is then replaced with a fixation image and the cycle repeated. The time taken to saccade plus the intensity of the stimulus are used to produce a retinal map of field of vision, or to assess other characteristics of the subject.
17 Citations
41 Claims
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1. A method of assessing eye function, comprising:
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(a) providing an image area in which images can be presented to the eye, and in which the luminance of any point in the image area over the desired field of view under test can be defined at least as accurately as the desired accuracy of a retinal map to be obtained; (b) forming a fixation image; (c) presenting a stimulus to the eye at a location within the image area spaced from the fixation image; (d) detecting a saccade triggered by said stimulus and immediately removing the original fixation image and creating a new fixation image at said location; (e) recording the timing and magnitude of the saccade and the subsequent fixation; (f) repeating steps (c) to (e), and (g) comparing the results with a database of typical eye responses, wherein each of the fixation images is an animated fixation image comprising a substantially stationary central region comprising at least 20% of the fixation image and a mobile perimeter defined such that the perimeter is greater than 3% of the arc of vision of the test subject in diameter. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 41)
where t is the total time for the luminance “
l”
to integrate to the detection threshold of the retina and P is the Pullfrich delay for an arbitrarily chosen luminance “
h”
where h=t·
1.
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4. The method of claim 3, in which t is derived from the function:
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5. The method of claim 4, in which a software algorithm is used to solve Equation 2 and use the greater of the two results as the total amplified value sensitivity of a given retinal point whereby relative sensitivity of the retina from one point to another is expressed directly as a function oft and can be derived by the software from the interval time T.
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6. The method claim 3, in which the intensity of “
- l”
is adjusted to vary the resolution of the measurement.
- l”
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7. The method of claim 6, in which “
- l”
is adjusted to give an average saccade time of between 200 and 800 ms for maximum comfort and accuracy.
- l”
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8. The method of claim 3, in which the resulting value of “
- t”
is used directly to plot a relative sensitivity map of the retina.
- t”
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9. The method of claim 3, in which a software algorithm is provided to translate the relative values of T to commonly used units of measure of the retinal threshold sensitivity by look up table or direct function based on the Blondel-Rey law or Bloch'"'"'s law.
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10. The method of claim 3, in which the stimulus can be increased or decreased in brightness from its initial presentation brightness during presentation, such an increase or decrease being used to modify the function of T to t to make the resulting function either more or less linear whereby to maintain the overall test speed at a rate most comfortable to the patient.
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11. The method of claim 3, in which several images are simultaneously presented of a resolution of less than 0.3 degrees only resolvable by the fovea, such that the eye is induced to sequentially saccade at the natural saccade frequency of the patient'"'"'s natural visual scanning mode.
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12. The method of claim 11, in which the value of “
- l”
is selected to induce a saccade frequency close to the said natural scanning mode.
- l”
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13. The method of claim 1, in which a sequence of visual stimuli is presented in said image area in a random or pseudo random sequence such that the position and preferably the expected time of appearance of the next stimulus in a sequence is not readily apparent to a person viewing the display.
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14. The method of claim 3, in which the timing information is compared to a database of timings for a population of humans of various ages such that the integrated timings of T can be compared to an average population of the same age as the patient under test such that the said value of T can be assigned the value of zero.
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15. The method of claim 14, in which the timing information is compared with a further model of the relative normal values of integral T over the full area of the retina such that the normal variations of the retinal sensitivity with respect to angle from fovea may be corrected to zero such that any deviation from, the norm will be represented as positive or negative values relative to the normal value.
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16. The method of a claim 1, in which there are displayed images containing a known priority sequence of predictable fixation points at separations of greater than 10 degrees of approximately half or less the average brightness of the image and where at least one region contains a further sub-image of a recognizable structure or alphanumeric character or pictorial representation of an object with a resolution of approximately 0.25 degrees per cycle;
- and in which an alarm or notification is delivered when more than one sequence of saccades of sub 100 ms and greater than 10 degrees occurs per overall image and records the overall time of the sequence of sub 100 mS saccades.
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17. The method of claim 16, in which said image is a cartoon character, an animal picture, a vehicle, or a personality.
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18. The method of claim 16, in which the threshold of 100 mS is varied to accommodate intoxicated, brain-damaged or other abnormal patients based on an average timing of a sequence of single region of interest images as the norm for a given intoxication, brain impairment or other abnormality.
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19. The method of claim 16, in which the images are part of a video or moving film sequence.
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20. The method of claim 19, in which the initial fixation cue comprises the termination of motion of an image that induces the eye pursuit of said image.
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21. The method of claim 1, in which the image contains a moving stimulus traveling across the display and where a sub-image of high detail only capable of discrimination by the fovea is presented for a period adjustable between 100-600 mS within a given time of the presentation of a simple bright stimulus on the opposite point of an axis drawn through the moving stimulus, said given time being shorter than the time required by the subject to saccade to the simple stimulus and back to the complex stimulus, preferably 50 ms.
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22. The method of claim 1, in which the first fixation image is formed by a dark area to which the eye is drawn by an image area giving an impression of perspective, and in which at least the first stimulus is formed by an image area of high spatial frequency.
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41. A software package containing data enabling the essential timing, control and display mechanisms for carrying out the method of claim 1 using commercially available display, camera and measurement devices.
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23. Apparatus for use in assessing eye function, comprising:
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(a) display means for presenting images to the eye where the luminance of any point in the image over the desired field of view under test can be defined at least as accurately as the desired accuracy of a retinal map to be obtained; (b) means for generating on the display means an initial fixation image; (c) means for generating a stimulus on the display means at a location spaced from the fixation image; (d) means for detecting a saccade triggered by said stimulus and immediately removing the initial fixation image and creating a new fixation image at said location;
(e) means for recording the timing and magnitude of each saccade and subsequent fixation and for comparing the results with a database of typical eye responses,wherein each of the initial and subsequent fixation images is an animated image comprising a substantially stationary central region comprising at least 20% of the fixation image and a mobile perimeter defined such that the perimeter is greater than 3% of the arc of vision of the test subject in diameter. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40)
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Specification