Stent lining
First Claim
Patent Images
1. A method for lining a stent, comprising:
- (a) providing a catheter assembly comprising a balloon at least a portion of which is coated with a hydrogel, wherein said hydrogel comprises a therapeutic agent selected from the group consisting of an anti-platelet drug, an anticoagulant drug, an anti-metabolite drug, an anti-angiogenic drug or an anti-proliferative drug, wherein an expansible stent is mounted on said balloon in a contracted condition,(b) introducing said assembly into a body lumen; and
(c) inflating said balloon to lodge said stent in said body lumen and to release said hydrogel from said coated portion to an inner surface of said stent as a lining.
1 Assignment
0 Petitions
Accused Products
Abstract
The invention features a catheter assembly and methods for delivering a hydrogel-lined stent to a body lumen, and methods for lining a stent with a hydrogel. The assembly includes a catheter which has a balloon at least a portion of which is coated with a hydrogel and an expansible stent mounted on the balloon in a contracted condition for passage with the catheter to a site of a body. Expansion of the balloon lodges the stent in the body with hydrogel coated on the inner surfaces of the stent as a lining.
222 Citations
47 Claims
-
1. A method for lining a stent, comprising:
-
(a) providing a catheter assembly comprising a balloon at least a portion of which is coated with a hydrogel, wherein said hydrogel comprises a therapeutic agent selected from the group consisting of an anti-platelet drug, an anticoagulant drug, an anti-metabolite drug, an anti-angiogenic drug or an anti-proliferative drug, wherein an expansible stent is mounted on said balloon in a contracted condition, (b) introducing said assembly into a body lumen; and (c) inflating said balloon to lodge said stent in said body lumen and to release said hydrogel from said coated portion to an inner surface of said stent as a lining. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
-
-
16. A method of lining a stent positioned in a body lumen, comprising:
-
(a) providing a catheter comprising a balloon at least a portion of which is coated with a hydrogel, wherein said hydrogel is selected from the group consisting of a polyacid, cellulosic polymer, collagen, gelatin, albumin, alginate, poly-2-hydroxy ethyl methyl acrylate (HEMA), polyvinylpyrrolidone, maleic anhydride polymer, polyamide, polyacrylamide, polyvinyl alcohol, polyethylene glycol, polyethylene oxide, and polysaccharide, wherein the hydrogel comprises a therapeutic agent selected from the group consisting of an anti-platelet drug, an anticoagulant, an anti-metabolite drug, an anti-angiogenic agent or an anti-proliferative drug; (b) introducing said catheter into said body lumen; (c) advancing said catheter in said body lumen until said coated portion is positioned proximate to an inner surface of said stent; and (d) inflating said balloon to release said hydrogel from said coated portion to said inner surface of said stent as a lining. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
-
-
32. A method of lining a stent positioned in a body lumen, comprising:
-
(a) providing a catheter comprising a balloon and a delivery port, wherein said balloon comprises a first layer and a second outer apertured layer overlying said delivery port; (b) introducing said catheter into said body lumen; (c) advancing said catheter in said body lumen until said outer apertured layer is positioned proximate to an inner surface of said stent; (d) delivering a hydrogel into a space between said first layer and said second outer apertured layer, wherein said hydro gel is selected from the group consisting of a polyacid, cellulosic polymer, collagen, gelatin, albumin, alginate, poly-2-hydroxy ethyl methyl acrylate (HEMA), polyvinylpyrrolidone, maleic anhydride polymer, polyamide, polyacrylamide, polyvinyl alcohol, polyethylene glycol, polyethylene oxide, and polysaccharide, wherein the hydrogel comprises a therapeutic agent selected from the group consisting of an anti-platelet drug, an anticoagulant, an anti-metabolite drug, an anti-angiogenic agent or an anti-proliferative drug; and (e) inflating said balloon to press said hydrogel through said outer apertured layer, wherein said hydrogel is deposited on said inner surface of said stent as a lining. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47)
-
Specification