Device for analyte measurement

• US 7,378,270 B2
• Filed: 11/09/2004
• Issued: 05/27/2008
• Est. Priority Date: 11/10/2003
• Status: Expired due to Fees

• Current Assignee: Sentec Pte Ltd
• Original Assignee: Sentec Scientific, Inc.
• Inventors: Walker, James W., Azarnia, Roobik
• Primary Examiner(s): Griffin; Walter D.
• Assistant Examiner(s): Doe; Shanta G
• Application Number:
  US10/984,599
• Publication Number:
  US 20050214881A1
• Time in Patent Office: 1,295 Days
• Field of Search: 435/287.2, 435/287.3, 435/7.92, 422/82.05, 221/87, 436/514
• US Class Current: 435/287.2
• CPC Class Codes: G01N 2035/00019 cassette structures
• CPC Class Codes: G01N 33/48764 Test tape taken off a spool
• CPC Class Codes: G01N 35/00009 provided with a sample supporting tape, e.g. with absorbent zones

Abstract

A biochemical analysis instrument for multiple fluid analyses includes a housing. A sensor for sensing a reaction is disposed in the housing. An aperture is formed in the housing. A test tape housing area is formed in the housing, and the sensor is disposed to selectively move within the housing area; the aperture being formed to provide access to the tape housing area. A cassette is configured to be received within the tape housing area. The cassette includes a case. First and second chambers are formed in the case. A gap is formed in the case. The first chamber and second chamber are disposed at a respective side of the gap. A test tape disposed within the housing extends from the first chamber across the gap to the second chamber. The test tape includes a plurality of active zones disposed at predetermined spaced intervals along the tape for testing an analyte.

Claims

1. A biochemical analysis instrument for multiple fluid analyses includes:

a housing;

a sensor for sensing a reaction disposed in said housing;

an aperture formed in said housing;

a test tape housing area formed in said housing, said sensor being disposed to selectively move within said housing area, said aperture being formed to provide access to said tape housing area; and

a cassette configured to be received within said tape housing area;

said cassette including a case, a first chamber formed in said case, a second chamber formed in said case, a gap formed in said case, said first chamber and second chamber being disposed at a respective side of said gap, a test tape disposed within said housing extending from said first chamber across said gap to said second chamber, said test tape having a plurality of active zones disposed at predetermined spaced intervals along said tape for testing an analyte;

said active zone including a reagent disposed on said test tape at said active zone;

said test tape including a support layer; and

each active zone including at least a first separating member and a second separating member, said first separating member disposed on said support layer across a gap from a second separating member disposed on said support layer;

a reagent disposed within said gap between said first separating member and said second separating member; and

said first separating member and said second separating member together are substantially U-shaped; and

a venting slit separating said first separating member from said second separating member.

2. A biochemical analysis instrument for multiple fluid analyses includes:

a housing;

a sensor for sensing a reaction disposed in said housing;

an aperture formed in said housing;

a test tape housing area formed in said housing, said sensor being disposed to selectively move within said housing area, said aperture being formed to provide access to said tape housing area; and

a cassette configured to be received within said tape housing area;

said cassette including a case, a first chamber formed in said case, a second chamber formed in said case, a gap formed in said case, said first chamber and second chamber being disposed at a respective side of said gap, a test tape disposed within said housing extending from said first chamber across said gap to said second chamber, said test tape having a plurality of active zones disposed at predetermined spaced intervals along said tape for testing an analyte;

said active zone including a reagent disposed on said test tape at said active zone;

said test tape including a support layer; and

each active zone includes at least a first separating member and a second separating member, said first separating member disposed on said support layer across a gap from a second separating member disposed on said support layer;

a reagent disposed within said gap between said first separating member and said second separating member; and

said tape having a cover layer, said first separating member and said second separating member being disposed between said support layer and said cover layer.

5. The instrument of claim 2, wherein said tape further comprises lands disposed between adjacent pairs of said separating members.

6. The instrument of claim 2, further comprising a spool disposed in at least one of said first chamber and second chamber, and said tape further comprising sprocket alignment holes disposed along at least one edge of said tape for engagement with said spool, said tape traveling along a travel path within said cassette from said first chamber to said second chamber and being wound about said spool.

7. The instrument of claim 6, wherein said path traverses said gap in said casing to selectively expose each active zone to an analyte.

8. The instrument of claim 2, wherein said reagent includes an enzyme, said reagent causes a changing of color when the analyte is a targeted analyte.

9. The instrument of claim 2, wherein said reagent includes an enzyme, said reagent causes a reaction which generates an electrochemical signal when the analyte is a targeted analyte.

3. A biochemical analysis instrument for multiple fluid analyses includes:

a housing;

a sensor for sensing a reaction disposed in said housing;

an aperture formed in said housing;

a test tape housing area formed in said housing, said sensor being disposed to selectively move within said housing area, said aperture being formed to provide access to said tape housing area; and

a cassette configured to be received within said tape housing area;

said cassette including a case, a first chamber formed in said case, a second chamber formed in said case, a gap formed in said case, said first chamber and second chamber being disposed at a respective side of said gap, a test tape disposed within said housing extending from said first chamber across said gap to said second chamber, said test tape having a plurality of active zones disposed at predetermined spaced intervals along said tape for testing an analyte;

said active zone including a reagent disposed on said test tape at said active zone;

said test tape including a support layer; and

each active zone including at least a first separating member and a second separating member, said first separating member disposed on said support layer across a gap from a second separating member disposed on said support layer;

a reagent disposed within said gap between said first separating member and said second separating member; and

a cleansing member, said cleansing member being disposed between respective adjacent active zones.

4. The instrument of claim 3, wherein said cleansing member extends from said support layer from a surface of said support layer which is the opposed surface to a surface of said support layer which supports said separating members.

10. A biochemical analysis cassette comprising:

a case;

a first chamber formed in said case;

a second chamber formed in said case, a gap formed in said case, said first chamber and second chamber being disposed at a respective side of said gap;

a test tape disposed within said case extending from said first chamber across said gap to said second chamber, said test tape having a plurality of active zones disposed at predetermined spaced intervals along said test tape for testing an analyte, said active zone including a reagent disposed on said test tape at said active zone and wherein said test tape includes a support layer and each active zone includes at least a first separating member and a second separating member, said first separating member disposed on said support layer across a gap from a second separating member disposed on said support layer; and

a reagent disposed within said gap between said first separating member and said second separating member;

said first separating layer and said second separating layer together are substantially U-shaped; and

further comprising a venting slit separating said first separating member from said second separating member.

14. The cassette of claim 10, wherein said tape further comprises lands disposed between adjacent pairs of said separating members.

15. The cassette of claim 10, further comprising a spool disposed in at least one of said first chamber and second chamber, and said tape further comprising sprocket alignment holes disposed along at least one edge of said tape for engagement with said spool, said tape traveling along a travel path within said cassette from said first chamber to said second chamber and being wound about said spool.

16. The cassette of claim 15, wherein said path traverses said gap in said casing to selectively expose each active zone to an analyte.

17. The cassette of claim 10, wherein said reagent includes an enzyme, said reagent causes a changing of color when the analyte is a targeted analyte.

18. The cassette of claim 10, wherein said reagent includes an enzyme, and said reagent causes a reaction which generates an electrochemical signal when the analyte is a targeted analyte.

11. A biochemical analysis cassette comprising:

a case;

a first chamber formed in said case;

a second chamber formed in said case, a gap formed in said case, said first chamber and second chamber being disposed at a respective side of said gap;

a test tape disposed within said case extending from said first chamber across said gap to said second chamber, said test tape having a plurality of active zones disposed at predetermined spaced intervals along said test tape for testing an analyte, said active zone including a reagent disposed on said test tape at said active zone and said test tape including a support layer and each active zone including at least a first separating member and a second separating member, said first separating member disposed on said support layer across a gap from a second separating member disposed on said support layer; and

a reagent disposed within said gap between said first separating member and said second separating member;

said tape including a cover layer, said first separating member and said second separating member being disposed between said support layer and said cover layer.

12. A biochemical analysis cassette comprising:

a case;

a first chamber formed in said case;

a second chamber formed in said case, a gap formed in said case, said first chamber and second chamber being disposed at a respective side of said gap;

a test tape disposed within said case extending from said first chamber across said gap to said second chamber, said test tape having a plurality of active zones disposed at predetermined spaced intervals along said test tape for testing an analyte, said active zone including a reagent disposed on said test tape at said active zone and wherein said test tape including a support layer and each active zone including at least a first separating member and a second separating member, said first separating member disposed on said support layer across a gap from a second separating member disposed on said support layer; and

a reagent disposed within said gap between said first separating member and said second separating member;

said cleansing member being disposed between respective adjacent active zones.

13. The cassette of claim 12, wherein said cleansing member extends from said support layer from a surface of said support layer which is the opposed surface to a surface of said support layer which supports said separating members.

19. A biochemical analysis instrument for multiple fluid analyses includes:

a housing;

a sensor for sensing a reaction disposed in said housing;

an aperture formed in said housing;

a test tape housing area formed in said housing, said sensor being disposed to selectively move within said housing area, said aperture being formed to provide access to said tape housing area; and

a cassette configured to be received within said tape housing area;

said cassette including a case, a first chamber formed in said case, a second chamber formed in said case, a gap formed in said case, said first chamber and second chamber being disposed at a respective side of said gap, a test tape disposed within said housing extending from said first chamber across said gap to said second chamber, said test tape having a plurality of active zones disposed at predetermined spaced intervals along said tape for testing an analyte;

said active zone includes a reagent disposed on said test tape at said active zone; and

a cleansing member, said cleansing member being disposed between respective adjacent active zones along said test tape.

20. The instrument of claim 19, wherein said test tape further comprises a support layer, said active zone and said cleansing members being disposed on said support layer, and said cleansing member extends from said support layer from a surface of said support layer which is the opposed surface to a surface of said support layer which supports said active zones.

21. A biochemical analysis instrument for multiple fluid analyses includes:

a housing;

a sensor for sensing a reaction disposed in said housing;

an aperture formed in said housing;

a test tape housing area formed in said housing, said sensor being disposed to selectively move within said housing area, said aperture being formed to provide access to said tape housing area;

a cassette configured to be received within said tape housing area;

said cassette including a case, a first chamber formed in said case, a second chamber formed in said case, a gap formed in said case, said first chamber and second chamber being disposed at a respective side of said gap, a test tape disposed within said housing extending from said first chamber across said gap to said second chamber, said test tape having a plurality of active zones disposed at predetermined spaced intervals along said tape for testing an analyte, said active zone includes a reagent disposed on said test tape at said active zone; and

further includes a cleansing member, said cleansing member being disposed between respective adjacent active zones.

22. The instrument of claim 21, wherein said test tape further comprises a support layer, said active zone and said cleansing members being disposed on said support layer, and said cleansing member extends from said support layer from a surface of said support layer which is the opposed surface to a surface of said support layer which supports said active zones.