Oxygen enhancing membrane systems for implantable devices

  • US 7,379,765 B2
  • Filed: 07/21/2004
  • Issued: 05/27/2008
  • Est. Priority Date: 07/25/2003
  • Status: Active Grant
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First Claim
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1. An electrochemical glucose sensor for determining a presence or a concentration of glucose in a fluid, the sensor comprising:

  • a multilayer membrane system comprising a cell impermeable domain that is substantially impermeable to cells, a resistance domain configured to restrict a flow of the glucose therethrough, and an enzyme domain comprising an enzyme that reacts with the glucose in the fluid as it passes though the enzyme domain; and

    a working electrode comprising a conductive material, wherein the working electrode is configured to measure a product of a reaction of the enzyme with the glucose,wherein the enzyme domain, the resistance domain, and the cell impermeable domain each comprise a polymer material with a higher oxygen solubility than an oxyhydrocarbon polymer and wherein each of the enzyme domain, the resistance domain, and the cell impermeable domain is configured to be permeable to the glucose.

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