Method of making a biosensor

• US 7,386,937 B2
• Filed: 05/01/2006
• Issued: 06/17/2008
• Est. Priority Date: 10/04/1999
• Status: Expired due to Term

• Current Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Original Assignee: Roche Diagnostics Operations Incorporated (Roche Holding AG)
• Inventors: Diebold, Eric R., Hill, Brian S., Bhullar, Raghbir S., Surridge, Nigel A., Walling, Douglas P.
• Primary Examiner(s): ARBES, CARL J
• Application Number:
  US11/416,497
• Publication Number:
  US 20060200982A1
• Time in Patent Office: 778 Days
• Field of Search: 298/25, 298/46, 298/47, 219/121.11, 219/121.12, 219/121.18, 219/121.19
• US Class Current: 29/846
• CPC Class Codes: C12Q 1/001 Enzyme electrodes
• CPC Class Codes: G01N 27/3272 Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels optical biosensors G01N33/52
• CPC Class Codes: G01N 33/5438 Electrodes
• CPC Class Codes: H05K 1/0393 Flexible materials H05K1/038 takes precedence; specific organic compositions are classified in H05K1/0313 and subgroups
• CPC Class Codes: H05K 3/027 the conductive material being removed by irradiation, e.g. by photons, alpha or beta particles
• CPC Class Codes: Y10T 29/49007 Indicating transducer
• CPC Class Codes: Y10T 29/49117 Conductor or circuit manufacturing
• CPC Class Codes: Y10T 29/49155 Manufacturing circuit on or in base
• CPC Class Codes: Y10T 29/49156 with selective destruction of conductive paths

Abstract

A method of making a biosensor is provided. The method includes providing an electrically conductive material on a base and partially removing the conductive material using laser ablation from the base so that less than 90% of the conductive material remains on the base and at least one electrode pattern is formed from the conductive material. The at least one electrode pattern has an edge extending between two points. A standard deviation of the edge from a line extending between two points is less than about 6 μm along the length of the edge.

Claims

1. A method of making a biosensor, the method comprising the steps of:

providing an electrically conductive material on a base; and

partially removing the conductive material using laser ablation from the base so that less than 90% of the conductive material remains on the base and at least one electrode pattern is formed from the conductive material, the at least one electrode pattern having an edge extending between two points, a standard deviation of the edge from a line extending between two points being less than about 6 μ

m along the length of the edge.

2. The method of claim 1 wherein the standard deviation is less than about 2 μ

m.

3. The method of claim 1 wherein the standard deviation is less than about 1 μ

m.

4. The method of claim 1 wherein at least one electrode pattern is formed in less than about 0.25 seconds.

5. The method of claim 1 wherein at least one electrode pattern is formed in less than about 50 nanoseconds.

6. The method of claim 1 wherein said electrode pattern is formed in about 25 nanoseconds.

7. The method of claim 1 wherein the at least one electrode pattern has electrode fingers that cooperate with one another to define an electrode gap having a pre-determined width value, a standard deviation of the gap from the width value is less than about 4 μ

m.

8. The method of claim 7 wherein the gap standard deviation is less than about 3 μ

m.

9. The method of claim 7 wherein the gap standard deviation is less than about 1.0 μ

m.

10. The method of claim 1 wherein less than 50% of the conductive material remains on the base.

11. The method of claim 1 wherein less than 10% of the conductive material remains on the base.

12. The method of claim 1 wherein the conductive material is removed using laser ablation.