Fourier domain optical coherence tomography employing a swept multi-wavelength laser and a multi-channel receiver

• US 7,391,520 B2
• Filed: 07/01/2005
• Issued: 06/24/2008
• Est. Priority Date: 07/01/2005
• Status: Active Grant

• Current Assignee: Carl Zeiss Meditec Incorporated (Carl-Zeiss-Stiftung)
• Original Assignee: Carl Zeiss Meditec Incorporated (Carl-Zeiss-Stiftung)
• Inventors: Zhou, Yan, Everett, Matthew J.
• Primary Examiner(s): Chowdhury; Tarifur R
• Assistant Examiner(s): Hansen; Jonathan M
• Application Number:
  US11/174,158
• Publication Number:
  US 20070002327A1
• Time in Patent Office: 1,089 Days
• Field of Search: 356/479, 356/497
• US Class Current: 356/479
• CPC Class Codes: A61B 3/1005 for measuring distances inside the eye, e.g. thickness of the cornea A61B3/11 takes precedence
• CPC Class Codes: A61B 3/102 for optical coherence tomography [OCT]
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/0073 by tomography, i.e. reconstruction of 3D images from 2D projections A61B5/0066 takes precedence
• CPC Class Codes: G01B 2290/45 Multiple detectors for detecting interferometer signals
• CPC Class Codes: G01B 9/02004 using frequency scans
• CPC Class Codes: G01B 9/02069 Synchronization of light source or manipulator and detector
• CPC Class Codes: G01B 9/02091 Tomographic interferometers, e.g. based on optical coherence
• CPC Class Codes: G01J 2003/1239 and separate detectors
• CPC Class Codes: G01J 3/0259 Monolithic
• CPC Class Codes: G01J 3/10 Arrangements of light sources specially adapted for spectrometry or colorimetry
• CPC Class Codes: G01J 3/4532 Devices of compact or symmetric construction G01J3/4531 takes precedence
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B

Abstract

The present invention is an alternative Fourier domain optical coherence system (FD-OCT) and its associated method. The system comprises a swept multi-wavelength laser, an optical interferometer and a multi-channel receiver. By employing a multi-wavelength laser, the sweeping range for each lasing wavelength is substantially reduced as compared to a pure swept single wavelength laser that needs to cover the same overall spectral range. The overall spectral interferogram is divided over the individual channels of the multi-channel receiver and can be re-constructed through processing of the data from each channel detector. In addition to a substantial increase in the speed of each axial scan, the cost of invented FD-OCT system can also be substantially less than that of a pure swept source OCT or a pure spectral domain OCT system.

Claims

1. An optical coherence tomography (OCT) system comprising;

a light source generating light at a plurality of discrete wavelengths simultaneously, said light source being tunable to scan said plurality of discrete wavelengths across a range of wavelengths to generate a plurality of scans of different spectral regions in parallel over time;

a beam splitter for dividing the light along a sample and a reference path;

a detector for receiving light returned from both the sample and the reference paths and having a plurality of channels, each channel arranged to measure light within one of said different spectral regions and to simultaneously generate output signals in response to said discrete scanned wavelengths; and

a processor for analyzing the output signals to derive a reflectance distribution along the sample path.

2. An OCT system as recited in claim 1, wherein the spacing between the discrete wavelengths of the tunable light source is equal to or greater than the width of the spectral regions measured by the detector channels.

3. An OCT system as recited in claim 1, wherein the range of wavelength over which the discrete wavelengths are scanned is equal to or greater than the spacing between the discrete wavelengths.

4. An OCT system as recited in claim 1, wherein the spectral region measured by each detector channel is configured to slightly overlap the spectral region measured by the adjacent channels.

5. An OCT system as recited in claim 1, wherein the processor combines the measurements from the plurality of channels and performs a Fourier analysis to obtain said axial reflectance distribution.

6. An OCT system as recited in claim 1, wherein the light source generates at least ten discrete wavelengths.

7. An OCT system as recited in claim 1, wherein the scanning range of each discrete wavelength is at least 0.5 nanometers.

8. An OCT system as recited in claim 1, wherein the scanning range of each discrete wavelength is at least 1.0 nanometers.

9. An OCT system as recited in claim 1, wherein said detector includes an optical element for spectrally dispersing the light as a function of wavelength and selectively directing different spectral regions to said channels.

10. An OCT system as recited in claim 9, wherein the optical element for spectrally dispersing the light is a grating.

11. An OCT system as recited in claim 1, wherein said detector includes a plurality of bandpass filters for spectrally separating the light as a function of wavelength and selectively directing different spectral regions to said channels.

12. An OCT system as recited in claim 1, wherein said light source is a laser.

13. An OCT system as recited in claim 1, wherein said light source is a superluminescent diode (SLD) followed by a comb filter.

14. An OCT system as recited in claim 1, wherein said light source is a sampled grating based semiconductor laser.

15. An OCT system as recited in claim 1, wherein said light source is a Fabry-Perot based semiconductor laser.

16. An OCT system as recited in claim 1, wherein said light source is a ring or race track cavity based semiconductor laser.

17. An OCT system as recited in claim 1, wherein said light source includes a tunable filter as part of a laser cavity.

18. An OCT system as recited in claim 1, wherein the processor is synchronized with the tuning of the light source.

31. An OCT system as recited in claim 10, wherein said grating is monolithically integrated with a photodetector array, said array defining the channels of the detector.

19. A method of analyzing a sample using optical coherence tomography (OCT) comprising the steps of:

generating a light output having plurality of discrete wavelengths;

scanning each discrete wavelength across a range of optical wavelengths to generate a plurality of scans of different spectral regions in parallel over time;

splitting the light along a sample and a reference path;

combining the light received back from both sample and reference paths;

separating the received light into said different spectral regions;

simultaneously measuring each of the different spectral regions during the scanning step; and

analyzing the measurements to derive a reflectance distribution along the sample path.

20. A method as recited in claim 19, wherein the spacing between the discrete wavelengths is equal to or greater than the width of the measured spectral regions measured.

21. A method as recited in claim 19, wherein the range of wavelength over which the discrete wavelengths are scanned is equal to or greater than the spacing between the discrete wavelengths.

22. A method as recited in claim 19, wherein the light output is generated by a laser.

23. A method as recited in claim 19, wherein analysis step includes combining the measurements from the different spectral regions and performing a Fourier analysis to obtain said reflectance distribution.

24. A method as recited in claim 19, wherein the light output includes at least 10 discrete wavelengths.

25. A method as recited in claim 19, wherein the scanning range of each discrete wavelength is at least 0.5 nanometers.

26. A method as recited in claim 19, wherein the scanning range of each discrete wavelength is at least 1.0 nanometers.

27. An optical coherence tomography (OCT) system comprising:

a light source generating light at least ten discrete wavelengths simultaneously, said light source being tunable to scan said plurality of discrete wavelengths across a range of wavelengths to generate a plurality of scans of different spectral regions in parallel over time and wherein the scanning range of each discrete wavelength is at least 1.0 nanometers;

a beam splitter for dividing the light along a sample and a reference path;

a detector for receiving light returned from both the sample and the reference paths and having a plurality of channels, each channel arranged to measure light within one of said different spectral regions and to simultaneously generate output signals in response to said discrete scanned wavelengths; and

a processor synchronized with the tuning of the light source for analyzing the generated output signals to derive a reflectance distribution along the sample path.

28. An OCT system as recited in claim 27, wherein the spacing between the discrete wavelengths of the tunable light source is equal to or greater than the width of the spectral regions measured by the detector channels.

29. An OCT system as recited in claim 27, wherein the range of wavelength over which the discrete wavelengths are scanned is equal to or greater than the spacing between the discrete wavelengths.

30. An OCT system as recited in claim 27, wherein the spectral region measured by each detector channel is configured to slightly overlap the spectral region measured by the adjacent channels.

32. An OCT system as recited in claim 27, wherein detector includes a grating monolithically integrated with a photodetector array, said array defining the channels of the detector.