Implantable cardiac device and method for reduced phrenic nerve stimulation

• US 7,392,086 B2
• Filed: 04/26/2005
• Issued: 06/24/2008
• Est. Priority Date: 04/26/2005
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Sathaye, Alok S.
• Primary Examiner(s): Layno; Carl H.
• Assistant Examiner(s): LEE, YUN H
• Application Number:
  US11/114,569
• Publication Number:
  US 20060241711A1
• Time in Patent Office: 1,155 Days
• Field of Search: 607/9, 607/27
• US Class Current: 607/27
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36842 Multi-site stimulation in the same chamber
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation
• CPC Class Codes: A61N 1/3712 Auto-capture, i.e. automatic adjustment of the stimulation threshold

Abstract

Methods and devices for reducing phrenic nerve stimulation of cardiac pacing systems involve delivering a pacing pulse to a ventricle of a heart. A transthoracic impedance signal is sensed, and a deviation in the signal resulting from the pacing pulse may be used to determine phrenic nerve stimulation. Methods may further involve detecting the phrenic nerve stimulation from the pacing pulse by delivering two or more pacing pulse to the ventricle of the heart, and determining a temporal relationship. A pacing vector may be selected from the two or more vectors that effects cardiac capture and reduces the phrenic nerve stimulation. A pacing voltage and/or pulse width may be selected that provides cardiac capture and reduces the phrenic nerve stimulation. In other embodiments, a pacing pulse width and a pacing voltage may be selected from a patient'"'"'s strength-duration curve that effects cardiac capture and reduces the phrenic nerve stimulation.

Claims

1. A medical device, comprising:

a plurality of electrodes electrically coupled to a heart;

a pulse delivery circuit configured to deliver a plurality of pacing pulses to a heart using the plurality of electrodes;

a transthoracic impedance sensor configured to sense a transthoracic impedance signal; and

a control circuit coupled to the sensing circuit and the transthoracic impedance sensor, the control circuit configured to determine the presence of phrenic nerve stimulation resulting from the pacing pulses based on deviations in the transthoracic impedance signal corresponding to delivery of the plurality of pacing pulses and verify the presence of phrenic nerve stimulation resulting from the pacing pulses based on an additional deviation in the transthoracic impedance signal corresponding to an additional pulse delivered during a cardiac refractory period of the heart by the pulse delivery circuit using the plurality of electrodes.

2. The device of claim 1, wherein the control circuit is configured to provide pacing pulse parameters to the pulse delivery circuit that reduce phrenic nerve stimulation while maintaining cardiac capture.

3. The device of claim 1, wherein the control circuit is configured to determine one or more pacing pulse parameters that reduce phrenic nerve stimulation while maintaining cardiac capture.

4. The device of claim 1, wherein a signal processor is provided in a patient-external device or system, the signal processor and the control circuit coupled to respective communication devices to facilitate wireless communication between the signal processor and the control circuit.

5. The device of claim 1, wherein a signal processor is provided in a network server system, the signal processor and the control circuit coupled to respective communication devices to facilitate wireless communication between the signal processor and the control circuit.

6. The device of claim 1, wherein the control circuit is configured to select a pacing vector that reduces the phrenic nerve stimulation while maintaining cardiac capture.

7. The device of claim 1, wherein the deviations in the transthoracic impedance signal correspond to delivery of the plurality of pacing pulses when a delivery frequency of the pacing pulses corresponds to a frequency of the deviations in the transthoracic impedance signal.

8. The device of claim 1, further comprising a band pass filter centered at a frequency corresponding to a pacing rate of the plurality of pacing pulses, the band pass filter configured to filter the transthoracic impedance signal.

9. The device of claim 1, wherein the deviations in the transthoracic impedance signal correspond to delivery of the plurality of pacing pulses when each of the deviations are respectively sensed in one of a plurality of time windows, each of the time windows respectively opening in response to delivery of one of the plurality of pacing pulses and remaining open for up to about 500 milliseconds.

10. The device of claim 1, wherein the deviations in the transthoracic impedance signal correspond to delivery of the plurality of pacing pulses when the deviations temporally correspond to delivery of the plurality of pacing pulses.

11. The device of claim 1, wherein an extent of the deviations in the transthoracic impedance signal are determined relative to a predetermined threshold.

12. A medical device, comprising:

means for sensing an electrophysiologic signal from a heart;

means for delivering a plurality of pacing pulses to the heart;

means for detecting a cardiac signal following the pacing pulse;

means for sensing a transthoracic impedance signal;

means for detecting a phrenic nerve stimulation from the pacing pulses using a plurality of deviations in the transthoracic impedance signal corresponding to delivery of the plurality of pacing pulses; and

means for verifying the presence of phrenic nerve stimulation resulting from the pacing pulses based on an additional deviation in the transthoracic impedance signal corresponding to an additional pulse delivered during a cardiac refractory period.

13. The device of claim 12, comprising means for determining a temporal relationship between the transthoracic impedance signal and the electrophysiologic signal.

14. The device of claim 12, comprising means for selecting a pacing vector that effects cardiac capture and reduces the phrenic nerve stimulation.

15. The device of claim 12, comprising means for selecting a pacing voltage that effects cardiac capture and reduces the phrenic nerve stimulation.

16. The device of claim 12, comprising means for selecting a pacing pulse width that effects cardiac capture and reduces the phrenic nerve stimulation.

17. The device of claim 12, comprising means for transmitting information associated with the sensed electrophysiologic signals and the sensed transthoracic impedance signal to a patient-external device.

18. The device of claim 12, wherein the plurality of deviations in the transthoracic impedance signal correspond to delivery of the plurality of pacing pulses when a delivery frequency of the pacing pulses corresponds to a frequency of the plurality of deviations in the transthoracic impedance signal.

19. The device of claim 12, wherein the plurality of deviations in the transthoracic impedance signal correspond to delivery of the plurality of pacing pulses when the plurality of deviations temporally correspond to delivery of the plurality of pacing pulses.