Closed-loop method for controlling insulin infusion

  • US 7,402,153 B2
  • Filed: 03/31/2004
  • Issued: 07/22/2008
  • Est. Priority Date: 06/09/1997
  • Status: Expired due to Term
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First Claim
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1. A method of infusing a fluid into a body of a user, the method comprising:

  • obtaining a current blood glucose concentration of the user;

    generating a controller input based on the current blood glucose concentration;

    generating commands by a proportional plus, integral plus, derivative (PID) controller from the controller input using at least one preset controller gain, wherein a proportional component and a derivative component of the PID controller are combined to represent a first phase insulin response, as measured from a normal glucose tolerant individual, and an integral component of the PID controller represents a second phase insulin response, as represented by the steady increase in insulin release under hyperglycemic clamp; and

    infusing the fluid based on the commands from the PID controller;

    wherein the PID controller accurately estimates a hypoglycemic glucose excursion.

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