Immunoglobulin chimeric monomer-dimer hybrids

  • US 7,404,956 B2
  • Filed: 05/06/2004
  • Issued: 07/29/2008
  • Est. Priority Date: 05/06/2003
  • Status: Active Grant
First Claim
Patent Images

1. An isolated monomer-dimer hybrid immunoconjugate comprising
X-La-F1:

  • F2 or F2;

    F1-La-XwhereinX is a single biologically active molecule,L is a linker,a is any integer or zero,;

    represents a chemical association,F1 is at least a portion of an immunoglobulin constant region comprising an FcRn binding site and does not comprise a biologically active molecule, andF2 is at least a portion of an immunoglobulin constant region comprising an FcRn binding site and does not comprise a biologically active molecule or immunoglobulin variable region.

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