Coil for magnetic stimulation

• US 7,407,478 B2
• Filed: 10/19/2001
• Issued: 08/05/2008
• Est. Priority Date: 10/20/2000
• Status: Active Grant

• Current Assignee: The United States of America As Represented By The Secretary of Agriculture
• Original Assignee: United States Department Of Health And Human Services
• Inventors: Hallett, Mark, Zangen, Abraham, Roth, Yiftach, Wise, Roy A., Miranda, Pedro Cavaleiro
• Primary Examiner(s): Gilbert; Samuel G
• Application Number:
  US10/399,559
• Publication Number:
  US 20040078056A1
• Time in Patent Office: 2,482 Days
• Field of Search: 600 9- 15, 607/45, 607/58
• US Class Current: 600/13
• CPC Class Codes: A61N 2/006 for magnetic stimulation of nerve tissue
• CPC Class Codes: A61N 2/02 using magnetic fields produced by coils, including single turn loops or electromagnets A61N2/12 takes precedence

Abstract

A magnetic stimulator, which may be used as a transcranial magnetic stimulation (TMS) device, and a method for its use are disclosed. The stimulator comprises a frame and an electrically conductive coil having a partially toroidal or ovate base and an outwardly projecting extension portion. The frame may be a flexible or malleable material and may be non-conductive. The electrically conductive coil may comprise one or more windings of electrically conductive material (such as a wire) coupled to the frame. The coil is electrically connected to a power supply. The device may be placed adjacent to or in contact with the body of a subject, such as on the head of a subject. The device may be used on humans for treating certain physiological conditions, such as cardiovascular or neurophysiological conditions, or for studying the physiology of the body. This device is useful in studying or treating neurophysiological conditions associated with the deep regions of the brain, such as drug addiction and depression.

Claims

1. A magnetic stimulator for placing externally of a body part of a subject and operable to induce currents within the body, comprising:

an electrically conductive coil, where the coil comprises a base portion and an extension portion, the extension portion comprising plural extension elements projecting outwardly from the base portion,

wherein the base portion comprises multiple stimulating elements and wherein the extension portion comprises multiple return elements for return paths for current in the stimulating elements, the return elements being spaced from the stimulating elements so that the electrical effect of the return path current on the body part is reduced.

2. The magnetic stimulator according to claim 1, further comprising a frame.

3. The magnetic stimulator according to claim 2 where the coil comprises a winding associated with the frame.

4. The magnetic stimulator according to claim 1 where the base portion has a length axis and a width axis, the coil in the base portion comprising elements spaced apart and transverse to the length axis such that the flow current in these elements is in substantially the same direction.

5. The magnetic stimulator according to claim 4 where the base portion is a partially toroidal or ovate base.

6. The magnetic stimulator according to claim 4 where the base portion comprises plural laterally spaced frame members extending along the length axis.

7. The magnetic stimulator according to claim 6 where at least two of the laterally spaced frame members are in a substantially non-parallel orientation.

8. The magnetic stimulator according to claim 1 where at least two extension elements are coupled to the base portion adjacent each other.

9. The magnetic stimulator according to claim 8 where the extension elements are angularly disposed relative to each other.

10. The magnetic stimulator according to claim 1 where the plural extension elements comprise at least two groups of plural extension elements, where the extension elements of the same group are coupled to the base portion adjacent each other.

11. The magnetic stimulator according to claim 1 where an extension element comprises a pair of substantially parallel spaced elongate extension frame members, each extension frame member having an inner end and an outer end, the inner ends of the extension frame members coupled to the base portion, the outer ends of the extension frame members interconnected by a transverse spacer frame member.

12. The magnetic stimulator according to claim 1, further comprising a shield at least partially enclosing the extension portion.

13. The magnetic stimulator according to claim 1, further comprising a power supply electrically connected to the coil.

14. The magnetic stimulator according to claim 1 where the base has a concave first side configured to be complementary to the cranium of a subject.

15. The magnetic stimulator according to claim 1 where the coil comprises means for inducing an electric field within the deep region of the brain.

16. The magnetic stimulator of claim 1, wherein the body part is a skull.

17. The magnetic stimulator of claim 1, wherein the extension portion is configured to place electrical currents flowing through return paths away from the region of the body part having the induced currents.

18. The magnetic stimulator of claim 1, wherein the base portion comprises plural longitudinally-extending laterally spaced frame members.

19. The magnetic stimulator of claim 1, wherein a majority of the current flowing through the base portion is oriented substantially in a single direction.

20. A method of treating a neurophysiological condition, comprising:

identifying a subject suffering a neurophysiological condition;

placing a magnetic stimulator external to the subject'"'"'s skull; and

activating the coil to stimulate the deep region of the subject'"'"'s brain,

the magnetic stimulator comprising a base with a first side to be directed toward a body part of a subject, the base comprising multiple substantially parallel stimulating elements configured to conduct electrical current in substantially a single direction of current flow, thereby inducing electrical fields within the body part, and an extension portion projecting from a second side of the base and comprising multiple respective return elements for return paths for the current in the stimulating elements, the return elements being spaced from the stimulating elements so that the electrical effect of the return path current on the body part is reduced.

21. The method according to claim 20 where the neurophysiological condition is clinical depression, non-clinical depression, dysthymia, bipolar disorder, drug addiction, substance abuse, anxiety disorder, obsessive compulsive disorder, or Parkinson'"'"'s disease.

22. A magnetic stimulator for placing externally of a body part of a subject and operable to induce currents within the body, comprising:

a base with a first side to be directed toward a body part of a subject, the base comprising multiple substantially parallel stimulating elements configuTed to conduct electrical current in substantially a single direction of current flow, thereby inducing electrical fields within the body part; and

an extension portion projecting from a second side of the base and comprising multiple respective return elements for return paths for the current in the stimulating elements, the return elements being spaced from the stimulating elements so that the electrical effect of the return path current on the body part is reduced.

23. The magnetic stimulator of claim 22, wherein the stimulating elements are complementary in shape and tangential to the surface of the body part when the magnetic stimulator is placed on the body part.

24. The magnetic stimulator of claim 22, wherein a majority of the current flowing through the base is oriented substantially in the single direction.

25. The magnetic stimulator of claim 22, wherein the respective return elements comprise current pathways configured to carry the current in a direction substantially opposite the current in the stimulating elements.

26. The magnetic stimulator of claim 22, wherein at least some of the respective return elements in the extension portion are spaced from their associated stimulating elements in the base by at least 5 cm.

27. The magnetic stimulator of claim 22, further comprising a shield placed around at least a portion of the extension portion, the shield being capable of inhibiting magnetic fields produced in the extension portion.

28. The magnetic stimulator of claim 22, where the base and the extension portion are part of one or more electrically conductive coils comprising one or more windings.

29. The magnetic stimulator of claim 22, where the extension portion is positioned off-center relative to the base.

30. The magnetic stimulator of claim 22, wherein the base is flexible or malleable.

31. The magnetic stimulator of claim 22, wherein the stimulating elements of the base are spaced apart from one another.

32. The magnetic stimulator of claim 22, wherein the base comprises substantially parallel, elongated frame members, and wherein the stimulating elements extend transversely between the frame members.

33. The magnetic stimulator of claim 22, wherein the extension portion is triangular and comprises at least two elongated extensions elements that extend away from the base and converge toward each other.

34. The magnetic stimulator of claim 22, wherein the extension portion comprises one or more extension elements projecting radially outwardly from the base.

35. The magnetic stimulator of claim 34, where an extension element comprises a pair of substantially parallel spaced elongate extension members, each extension member having an inner end and an outer end, the inner ends of the extension members coupled to the base, the outer ends of the extension members interconnected by a transverse member.

36. A method of treating or studying a cardiovascular condition, comprising:

identifying a subject at risk of suffering a cardiovascular condition;

placing the magnetic stimulator of claim 22 external to the subject'"'"'s body; and

activating the coil to stimulate the subject.

37. The method according to claim 36 where the cardiovascular condition comprises a cardiovascular event.

38. The method according to claim 37 where the cardiovascular event is a stroke.

39. A magnetic stimulator for placement externally of a body part of a subject and operable to induce currents within the body, the magnetic stimulator comprising:

an arcuate base having an inner face and an outer face, wherein the base is shaped to conform to a body part on which it is to be externally placed,

the base providing a plurality of stimulating current pathways for inducing the currents within the body, wherein the stimulating current pathways conduct current substantially in a single direction within the base to avoid return current pathways that flow in a direction opposite to the single direction and that would oppose or interfere with magnetic fields within the body produced by the stimulating current pathways; and

an extension portion extending away from the base that provides the return current pathways,

wherein the base comprises first and second spaced longitudinal sides and the stimulating current pathways extend transversely of the base between the first and second spaced longitudinal sides, and wherein current flows through the first and second longitudinal sides, the stimulating current pathways, and the extension portion.

40. A magnetic stimulator for placement externally of a body part of a subject and operable to induce currents within the body, the magnetic stimulator comprising:

an arcuate base having an inner face and an outer face, wherein the base is shaped to conform to a body part on which it is to be externally placed,

the base providing a plurality of stimulating current pathways for inducing the currents within the body, wherein the stimulating current pathways conduct current substantially in a single direction within the base to avoid return current pathways that flow in a direction opposite to the single direction and that would oppose or interfere with magnetic fields within the body produced by the stimulating current pathways; and

an extension portion extending away from the base that provides the return current pathways,

wherein the base comprises a pair of elongated members between which extend a plurality of the stimulating current pathways, and wherein the extension portion comprises one or more conductive elements that form a loop extending outwardly from the plane of the base.

41. A magnetic stimulator for placement externally of a body part of a subject and operable to induce currents within the body, the magnetic stimulator comprising:

an arcuate base having an inner face and an outer face, wherein the base is shaped to conform to a body part on which it is to be externally placed,

the base providing a plurality of stimulating current pathways for inducing the currents within the body, wherein the stimulating current pathways conduct current substantially in a single direction within the base to avoid return current pathways that flow in a direction opposite to the single direction and that would oppose or interfere with magnetic fields within the body produced by the stimulating current pathways; and

an extension portion extending away from the base that provides the return current pathways,

wherein the extension portion comprises a plurality of extension elements projecting outwardly from the base.

42. The magnetic stimulator of claim 41, wherein the stimulating current pathways are substantially parallel to one another and tangential to the external surface of the body part on which the magnetic stimulator is to be placed.

43. The magnetic stimulator of claim 41, wherein the stimulating current pathways are spaced apart from one another.

44. The magnetic stimulator of claim 41, wherein the base is flexible or malleable.

45. The magnetic stimulator of claim 41, wherein the extension portion is triangular and comprises at least two elongated extensions elements that extend away from the base and converge toward each other.

46. The magnetic stimulator of claim 41, wherein the extension elements project from the base.

47. The magnetic stimulator of claim 41, wherein the extension elements comprise pairs of substantially parallel spaced elongate members interconnected at their outward ends by transverse members.

51. A method of studying or treating a cardiovascular condition, comprising:

identifying a subject at risk of suffering a cardiovascular condition;

placing the magnetic stimulator of claim 41 external to the subject'"'"'s body; and

activating the coil to stimulate the subject.

52. The method according to claim 51 where the cardiovascular condition is a stroke.

48. A magnetic stimulator for placement externally of a body part of a subject and operable to induce currents within the body, the magnetic stimulator comprising:

an arcuate base having an inner face and an outer face, wherein the base is shaped to conform to a body part on which it is to be externally placed,

the base providing a plurality of stimulating current pathways for inducing the currents within the body, wherein the stimulating current pathways conduct current substantially in a single direction within the base to avoid return current pathways that flow in a direction opposite to the single direction and that would oppose or interfere with magnetic fields within the body produced by the stimulating current pathways;

an extension portion extending away from the base that provides the return current pathways; and

a shield positioned between the return pathways and the stimulating current pathways, the shield being configured to inhibit magnetic fields produced by the return pathways.

49. A method of studying or treating a neurophysiological condition, comprising:

identifying a subject suffering a neurophysiological condition;

placing a magnetic stimulator external to the subject'"'"'s skull; and

activating the magnetic stimulator to stimulate the deep region of the subject'"'"'s brain, the magnetic stimulator comprising,

an arcuate base having an inner face and an outer face, wherein the base is shaped to conform to a body part on which it is to be externally placed,

the base providing a plurality of stimulating current pathways for inducing the currents within the body, wherein the stimulating current pathways conduct current substantially in a single direction within the base to avoid return current pathways that flow in a direction opposite to the single direction and that would oppose or interfere with magnetic fields within the body produced by the stimulating current pathways; and

an extension portion extending away from the base that provides the return current pathways.

50. The method according to claim 49 where the neurophysiological condition is clinical depression, non-clinical depression, dysthymia, bipolar disorder, drug addiction, substance abuse, anxiety disorder, obsessive compulsive disorder, or Parkinson'"'"'s disease.

53. A magnetic stimulator for non-invasively inducing electrical fields in a body part of a subject, comprising:

means for producing stimulating currents that are complementary to an external surface of the body part and oriented in substantially a single direction; and

means for conducting return path currents associated with the stimulating currents away from the external surface of the body part so that the electrical effects of the return path currents on the body part are reduced.

54. The magnetic stimulator of claim 53, wherein the stimulating currents flow through substantially parallel and spaced apart conductive elements in a base portion of the magnetic stimulator.

55. The magnetic stimulator of claim 53, wherein the return path currents flow through conductive elements of the magnetic stimulator that extend away from the external surface of the body part.

56. An electrically conductive coil for placing externally of the skull of a subject and operable to induce currents within the brain of the subject, comprising:

a base portion, the base portion configured to provide a flow of electricity, thus producing a magnetic field in a region of the brain; and

an extension portion for providing a return path for the flow of electricity through the base, the extension portion configured to place electrical currents flowing through the return path away from the region of the brain having the produced magnetic field,

wherein the base portion comprises multiple substantially parallel and spaced apart stimulating elements configured to conduct electrical current in substantially a single direction of current flow, thereby inducing electrical fields within the region of the brain.

57. The electrically conductive coil of claim 56, wherein the extension portion comprises multiple return elements for respective return paths for the current in the stimulating elements.

58. The electrically conductive coil of claim 57, wherein the multiple return elements are spaced from the stimulating elements so that the electrical effect of the return path current on the body part is reduced.

59. The magnetic stimulator of claim 56, further comprising a power supply electrically connected to the coil.

60. The magnetic stimulator of claim 56, wherein the coil comprises a plurality of windings.

61. A magnetic stimulator for placing externally of the cranium of a subject and operable to induce currents within the body, comprising:

an electrically conductive coil comprising a base portion and an extension portion, the base portion having a width axis and a length axis, and a concave first side configured to be complementary to the cranium of a subject, the extension portion projecting outwardly from the base portion,

the coil in the base portion comprising elements spaced apart and transverse to the length axis such that the flow of current in these elements is in substantially the same direction; and

a shield at least partially enclosing the extension portion.

62. The magnetic stimulator of claim 61, wherein the base portion is a partially toroidal or ovate base and is substantially arcuate along its length axis and is substantially arcuate along its width axis.

63. The magnetic stimulator of claim 62, wherein the base portion has an arch length along the length axis from 10 to 50 centimeters.

64. The magnetic stimulator of claim 62, wherein the base portion has an arch length along the width axis in a range from 2 to 15 centimeters.

65. The magnetic stimulator of claim 61, wherein the base portion comprises plural longitudinally-extending laterally spaced frame members.

66. The magnetic stimulator of claim 65, wherein at least two of the longitudinally-extending laterally spaced frame members are in a substantially non-parallel orientation.

67. The magnetic stimulator of claim 61, wherein the extension portion is positioned off-center relative to the base portion.

68. A magnetic stimulator for placing externally of the cranium of a subject and operable to induce currents within the body, comprising:

an electrically conductive coil comprising a base portion and an extension portion, the base portion having a width axis and a length axis, and a concave first side configured to be complementary to the cranium of a subject, the extension portion projecting outwardly from the base portion,

the coil in the base portion comprising elements spaced apart and transverse to the length axis such that the flow of current in these elements is in substantially the same direction; and

a cushion coupled to the base portion.

69. The magnetic stimulator of claim 68, wherein the transverse elements are arcuate.

70. A method for magnetically stimulating a region of the brain of a subject, the method comprising:

providing at least one current pulse through a plurality of stimulating pathways that are spaced apart from one another and configured to orient electrical current in a first direction, the stimulating pathways being complementary to the outer surface of the cranium of the subject and adjacent to the region of the brain being stimulated; and

positioning electrical current that flows in a second direction opposite to the first direction away from the stimulating pathways so that the electrical effect of the current flowing in the second direction on the region of the brain being stimulated is reduced, wherein the electrical current flowing in the second direction flows through pathways that are removed from the surface of the cranium of the subject.

71. The method of claim 70, further comprising providing a first pulse of electrical current through a first subset of the stimulating pathways at a first time and providing a second pulse of electrical current through a second subset of the stimulating pathways at a second time after the first time.