Anti-neoplastic compositions comprising extracts of black cohosh

• US 7,407,675 B2
• Filed: 12/23/2003
• Issued: 08/05/2008
• Est. Priority Date: 12/27/2002
• Status: Expired due to Fees

• Current Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Original Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Inventors: Einbond, Linda Saxe, Weinstein, I. Bernard
• Primary Examiner(s): FLOOD, MICHELE C
• Application Number:
  US10/746,960
• Publication Number:
  US 20050008717A1
• Time in Patent Office: 1,687 Days
• Field of Search: 424/764, 514/2, 514/783
• US Class Current: 424/764
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/704 attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin digitoxin A61K31/7048
• CPC Class Codes: A61K 36/71 Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 35/02 specific for leukemia

Abstract

The present invention provides a composition for use in treating or preventing neoplasia, comprising an effective actein. The present invention also provides a composition for use in treating or preventing neoplasia, comprising an effective anti-neoplastic amount of an ethyl acetate extract of black cohosh. The present invention further provides a combination of anti-neoplastic agents, comprising an effective anti-neoplastic amount of an ethyl acetate extract of black cohosh and an effective anti-neoplastic amount of at least one additional chemopreventive or chemotherapeutic agent. Methods for treating and preventing neoplasia are also provided.

Claims

1. A composition for use in treating neoplasia, comprising an effective anti-neoplastic amount of an ethyl acetate fraction of a methanol/water extract of roots and rhizomes of Actaea racemosa L.

2. The composition of claim 1, wherein the ethyl acetate fraction comprises at least one triterpene glycoside compound.

3. The composition of claim 2, wherein the triterpene glycoside compound is selected from the group consisting of actein, cimifugoside, cimigenol glycoside, cimiracemoside A, and 23-epi-26-deoxyactein.

4. The composition of claim 3, wherein the triterpene glycoside compound is actein.

5. The composition of claim 4, wherein the effective anti-neoplastic amount of actein is between about 0.5 μ

g/ml and about 40.0 μ

g/ml.

6. The composition of claim 5, wherein the effective anti-neoplastic amount of actein is between about 1.0 μ

g/ml and about 3.0 μ

g/ml.

7. The composition of claim 1, wherein the ethyl acetate fraction comprises at least one aglycone.

8. The composition of claim 7, wherein the at least one aglycone is cimigenol.

9. A composition comprising from about 20 μ

g/ml to about 40.0 μ

g/ml of an ethyl acetate fraction of a methanol/water extract of roots and rhizomes of Actaea racemosa L., which comprises at least one triterpene glycoside compound.