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Intracutaneous microneedle array apparatus

  • US 7,416,541 B2
  • Filed: 05/03/2005
  • Issued: 08/26/2008
  • Est. Priority Date: 06/09/1999
  • Status: Expired due to Term
First Claim
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1. An integral structure comprising a base element and plurality of microneedles formed thereon, said microneedles suitable for penetrating the stratum corneum layer of skin, wherein said base element has a first side and a second side;

  • said plurality of microneedles comprising a plurality of projections disposed on an outer surface of said microneedles and which extend from the second side of said base element along longitudinal axes, in a longitudinal direction from a proximal end towards a distal end, and exhibiting at least one angle with respect to said base element; and

    said plurality of projections being spaced apart from one another at a substantially predetermined separation distance, and said plurality of projections having a substantially uniform length,wherein said projections have at least one elongate sharp edge that enhances penetration of said microneedles through the stratum corneum layer of skin, wherein said elongate sharp edge is oriented in the longitudinal direction and extends in a direction from said proximal end of said microneedle towards said distal end of said microneedle, wherein said projections have a generally triangular cross section when viewed from said distal end of said microneedle, and wherein said generally triangular cross section has an outer angle in the range of 1 to 45 degrees.

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