Apparatus and method for monitoring breath acetone and diabetic diagnostics

• US 7,417,730 B2
• Filed: 03/31/2006
• Issued: 08/26/2008
• Est. Priority Date: 03/31/2006
• Status: Expired due to Fees

• Current Assignee: Los Alamos National Security LLC (Government of the United States of America)
• Original Assignee: Los Alamos National Security LLC (Government of the United States of America)
• Inventors: Duan, Yixiang, Cao, Wenqing
• Primary Examiner(s): EVANS, FANNIE L
• Application Number:
  US11/395,733
• Publication Number:
  US 20070229818A1
• Time in Patent Office: 879 Days
• Field of Search: 356/316
• US Class Current: 356/316
• CPC Class Codes: G01J 3/443 Emission spectrometry
• CPC Class Codes: G01N 21/67 using electric arcs or discharges
• CPC Class Codes: H05H 1/30 using applied electromagnetic fields, e.g. high frequency or microwave energy H05H1/28 takes precedence

Abstract

An apparatus and method for monitoring diabetes through breath acetone detection and quantitation employs a microplasma source in combination with a spectrometer. The microplasma source provides sufficient energy to produce excited acetone fragments from the breath gas that emit light. The emitted light is sent to the spectrometer, which generates an emission spectrum that is used to detect and quantify acetone in the breath gas.

Claims

1. A method for monitoring breath gas comprising:

providing sufficient energy from an atmospheric pressure plasma to a sample of breath gas to fragment and excite acetone in the breath gas, thereby generating light emission from the sample of breath gas;

directing the light emission to a spectrometer to generate an emission spectrum; and

analyzing the emission spectrum to determine the amount of acetone in the sample of breath gas.

2. The method of claim 1, wherein the atmospheric pressure plasma comprises a microplasma.

3. The method of claim 1, wherein the step of analyzing the emission spectrum to determine the amount of acetone in the sample of breath gas involves using the peak at 516.5 nanometers as a handle for detecting acetone in breath gas.

4. A method for monitoring breath acetone, comprising:

sending a sample of breath gas through atmospheric pressure plasma to excite and fragment volatile organic compounds in the sample and generate light emission therefrom;

directing at least a portion of the emitted light to a spectrometer;

using the spectrometer to produce a spectrum of the emitted light; and

analyzing the spectrum of the emitted light to determine the amount of breath acetone in the sample.

5. The method of claim 4, wherein the atmospheric pressure plasma comprises a microplasma.

6. The method of claim 5, wherein the step of analyzing the spectrum of the emitted light to determine the amount of breath acetone in the sample involves using the peak at 516.5 nanometers as a handle for detecting acetone in breath gas.