Microneedle transport device
First Claim
Patent Images
1. A transdermal transport device for transporting a substance through a surface of a body, comprising:
- a plurality of needles;
a first moving interface and a second moving interface; and
a first actuator connected to the first interface, and a second actuator connected to a second interface, the first actuator operating independently with respect to the second actuator;
the first actuator configured to expand the first moving interface to advance the plurality of needles relative to the housing through the surface of the body, and the first actuator being reversible to withdraw the plurality of needles from the body; and
the second actuator configured to expand the second moving interface to transport the substance by moving independently with respect to the first actuator through the surface of the body via the plurality of needles.
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Accused Products
Abstract
A transdermal transport device includes a reservoir for holding a formulation of an active principle, and an array of needles which have bores in fluid communication with the reservoir to facilitate transporting the formulation to and from the reservoir through the needles. The device also includes a first actuator which drives the array of needles into the body, and a second actuator which pumps the formulation between the reservoir and the body through the needles. The first actuator is reversible to withdraw the needles from the body.
227 Citations
73 Claims
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1. A transdermal transport device for transporting a substance through a surface of a body, comprising:
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a plurality of needles; a first moving interface and a second moving interface; and a first actuator connected to the first interface, and a second actuator connected to a second interface, the first actuator operating independently with respect to the second actuator; the first actuator configured to expand the first moving interface to advance the plurality of needles relative to the housing through the surface of the body, and the first actuator being reversible to withdraw the plurality of needles from the body; and the second actuator configured to expand the second moving interface to transport the substance by moving independently with respect to the first actuator through the surface of the body via the plurality of needles. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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35. A transdermal transport device for transporting a substance through a surface of a body, comprising:
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a plurality of needles; and a vapor generator actuator to transport the substance through the surface of the body via the needles, the vapor generator actuator comprising; an enclosed chamber containing a liquid; a moving interface separating the liquid from the substance; and a heater for heating the liquid to expand the volume of the liquid to force the moving interface against the liquid to pump the substance through the needle. - View Dependent Claims (36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46)
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47. A transdermal transport device for transporting a substance through a surface of a body, comprising:
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a plurality of needles; a first vapor generator actuator to drive the plurality of needles through the surface of the body; and a second vapor generator actuator to transport the substance through the needles and through the surface of the body. - View Dependent Claims (48)
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49. A transdermal transport device for transporting a substance through a surface of a body, comprising:
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a means for moving a reservoir towards the body and driving a plurality of needles into the body, each needle having a bore in fluid communication with the reservoir; and a means for transporting the substance from the reservoir through the needles into the body. - View Dependent Claims (50)
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51. A method of transporting a substance through a surface of a body, comprising:
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placing a delivery device at the body; and transporting the substance through the surface of the body via a plurality of needles with a first actuator, the first actuator comprising; an enclosed chamber containing a liquid; a moving interface separating the liquid from the substance; and a heater for heating the liquid to expand the volume of the liquid to force the moving interface against the liquid to pump the substance through the needle. - View Dependent Claims (52, 53, 54, 55, 56, 57, 58, 59, 60, 61)
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62. The method of 51 wherein the first actuator is automated.
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63. A method of transdermally transporting a substance through a surface of a body, comprising:
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placing a delivery device at the body; moving a reservoir holding the substance towards the body and advancing a plurality of needles connected in fluid communication with the reservoir, into the body with a first vapor generator actuator while generating longitudinal vibrations along the lengths of the plurality of needles to reduce a force required to advance the needles into the body; and transporting the substance from the reservoir though the plurality of needles into the body with a second vapor generator actuator. - View Dependent Claims (64, 65, 66, 67, 68)
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69. The method of 63 wherein each of the first and second vapor generator actuators is automated.
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70. A transdermal transport device for transporting a substance through a surface of a body, comprising:
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a plurality of needles; an actuator to advance the plurality of needles into the body; and a reversible actuator to selectively transport the substance in a first direction across the surface of the body via the plurality of needles and in a different direction across the surface of the body via the plurality of needles. - View Dependent Claims (71, 72, 73)
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Specification