Redox polymers for use in electrochemical-based sensors

• US 7,429,630 B2
• Filed: 05/04/2006
• Issued: 09/30/2008
• Est. Priority Date: 07/28/2004
• Status: Active Grant

• Current Assignee: Cilag Gmbh International (Johnson & Johnson)
• Original Assignee: LifeScan Scotland Limited (Johnson & Johnson)
• Inventors: Lillie, Geoffrey, Rodgers, James Jain, Liu, Zuifang
• Primary Examiner(s): PEZZUTO, HELEN LEE
• Application Number:
  US11/429,518
• Publication Number:
  US 20060205885A1
• Time in Patent Office: 880 Days
• Field of Search: 525/279, 525/283, 525/297, 525/298, 435/4, 435/14, 435/817
• US Class Current: 525/283
• CPC Class Codes: C12Q 1/002 Electrode membranes
• CPC Class Codes: C12Q 1/004 mediator-assisted
• CPC Class Codes: C12Q 1/006 for glucose
• CPC Class Codes: Y10S 435/817 Enzyme or microbe electrode

Abstract

A redox polymer for use in an electrochemical-based sensor includes a hydrophobic polymer backbone (e.g., a hydrophobic poly(methyl methacrylate) polymer backbone) and at least one hydrophilic polymer arm (such as a hydrophilic oligo(N-vinylpyrrolidinone) polymer arm) attached to the hydrophobic polymer backbone. The redox polymer also includes a plurality of redox mediators (e.g., ferrocene-based redox mediators) attached to the at least one hydrophilic polymer arm.

Claims

1. A redox polymer for use in an electrochemical-based sensor, the redox polymer comprising:

a hydrophobic polymer backbone;

at least one pendant hydrophilic polymer arm attached at a single point to the hydrophobic polymer backbone; and

a plurality of redox mediators for facilitating electron transfer between at least one redox enzyme of the electrochemical-based sensor and at least one electrode of the electrochemical-based sensor, the plurality of redox mediators attached to the at least one pendant hydrophilic polymer arm,

wherein each of the at least one hydrophilic pendant polymer arms has a plurality of the redox mediators attached thereto.

2. The redox polymer of claim 1, wherein the redox mediator is a ferrocene-based redox mediator.

3. The redox polymer of claim 1, wherein there are a plurality of pendant hydrophilic arms attached to the hydrophobic backbone and there is, on average, a plurality of redox mediators attached to each of the pendant hydrophilic polymer arms.