Pharmaceutical semi-solid composition of isotretinoin

  • US 7,435,427 B2
  • Filed: 09/21/2001
  • Issued: 10/14/2008
  • Est. Priority Date: 09/22/2000
  • Status: Active Grant
First Claim
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1. An oral pharmaceutical composition of isotretinoin contained in a pharmaceutically acceptable capsule which comprises a semi-solid suspension containing at least two lipidic excipients, at least in an amount of about 20 to 80% of one being hydrophilic having a HLB value equal to or greater than 10 selected from the group consisting of glyceroyl macrogolglycerides, polyethylene glycol esters, and mixtures thereof;

  • the other in an amount of about 5 to 70% and being an oily vehicle selected from the group consisting of vegetable oils, medium chain triglycerides, fatty acid esters, glycerol oleate and mixtures thereof; and

    an amount of about 1 to 10% of at least one additional surfactant.

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