Methods of treatment using a gastric retained gabapentin dosage

CAFC
  • US 7,438,927 B2
  • Filed: 10/25/2002
  • Issued: 10/21/2008
  • Est. Priority Date: 10/25/2001
  • Status: Active Grant
First Claim
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1. A method of treating epilepsy in a mammal comprising administering a therapeutically effective amount of a daily dosage of about 200 mg to about 4000 mg of gabapentin or a pharmaceutically acceptable salt thereof, dispersed in a gastric retained dosage form to the mammal in which a fed mode has been induced, wherein the dosage form comprises a single polymer matrix comprising at least one swellable hydrophilic polymer that swells in a dimensionally unrestrained manner by imbibing water to increase its size to promote gastric retention of the dosage form in the stomach of the mammal, and wherein upon contact with water, gabapentin is released by diffusion from the dosage form over a period of at least five hours and at least 40 wt % of the gabapentin is retained in the dosage form one hour after administration.

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