Process for the preparation of cinacalcet base
DCFirst Claim
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1. A process for preparing cinacalcet, comprising:
- a) reducing 3-trifluoromethyl cinnamic acid to obtain 3-[3-(trifluoromethyl) phenyl]propanoic acid;
b) optionally, converting the 3-[3-(trifluoromethyl)phenyl]propanoic acid into a compound of formula III
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Abstract
Provided is a process for preparing Cinacalcet, (R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethane amine and intermediates thereof.
12 Citations
42 Claims
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1. A process for preparing cinacalcet, comprising:
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a) reducing 3-trifluoromethyl cinnamic acid to obtain 3-[3-(trifluoromethyl) phenyl]propanoic acid; b) optionally, converting the 3-[3-(trifluoromethyl)phenyl]propanoic acid into a compound of formula III - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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10. A process for preparing cinacalcet, comprising:
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a) reducing 3-trifluoromethyl cinnamic acid to 3-[3-(trifluoromethyl)phenyl]propanoic acid; b) converting the 3-[3-(trifluoromethyl)phenyl]propanoic acid into cinacalcet. - View Dependent Claims (11, 12)
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- 32. A process for preparing cinacalcet, comprising reducing N-[(1S)-1-(1-naphthyl)ethyl]-3-[3-trifluoromethyl)phenyl propanamide to obtain cinacalcet.
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41. A process for preparing N-[( 1S)-1-(1-naphthyl)ethyl]-3-3-trifluoromethyl)phenyl] propanamide, comprising:
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a) reducing 3-trifluoromethyl cinnamic acid to obtain 3-[3-(trifluoromethyl)phenyl]propanoic acid; and b) converting the 3- [3-(trifluoromethyl)phenyl]propanoic acid into N-[(1S)- 1-(1-naphthyl)ethyl]-3-[3-trifluoromethyl)phenyl] propanamide.
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42. A process for preparing N-[(1S)-1-(1-naphthyl)ethyl]-3-[3-trifluoromethyl)phenyl] propanamide, comprising:
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a) reducing 3-trifluoromethyl cinnamic acid to obtain 3-[3-(trifluoromethyl)phenyl]propanoic acid; and b) preparing N-[(1S)-1-(1-naphthyl)ethyl]-3-[3-trifluoromethyl)phenyl]propanamide from the 3-[3-(trifluoromethyl)phenyl]propanoic acid.
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Specification