Closed loop cardiac resynchronization therapy using cardiac activation sequence information

• US 7,457,664 B2
• Filed: 05/09/2005
• Issued: 11/25/2008
• Est. Priority Date: 05/09/2005
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Meyer, Scott A., Stahmann, Jeffrey E., Zhang, Yi, McCabe, Aaron R., Yu, Yinghong, Ding, Jiang, Ricci, Carlos Alberto
• Primary Examiner(s): Layno; Carl H.
• Assistant Examiner(s): LEE, YUN H
• Application Number:
  US11/125,068
• Publication Number:
  US 20060253162A1
• Time in Patent Office: 1,296 Days
• Field of Search: 607/9
• US Class Current: 607/9
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/365 controlled by a physiological parameter, e.g. heart potential evoked response A61N1/371
• CPC Class Codes: A61N 1/3712 Auto-capture, i.e. automatic adjustment of the stimulation threshold

Abstract

Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track, and/or trend closed-loop cardiac resynchronization therapy using cardiac activation sequence information. Devices and methods involve sensing a plurality of composite cardiac signals using a plurality of electrodes, the electrodes configured for implantation in a patient. A source separation is performed using the sensed plurality of composite cardiac signals, producing one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences. A cardiac resynchronization therapy is adjusted using one or both of the one or more cardiac signal vectors and the signals associated with the one or more cardiac signal vectors. In further embodiments, the cardiac resynchronization therapy may be initiated, terminated, or one or more parameters of the resynchronization therapy may be altered.

Claims

1. A cardiac method, comprising:

sensing a plurality of composite cardiac signals using a plurality of electrodes, the electrodes configured for implantation in a patient;

performing a source separation using the sensed plurality of composite cardiac signals;

producing one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences based on the source separation; and

adjusting a cardiac resynchronization therapy using one or both of the one or more cardiac signal vectors and the signals associated with the one or more cardiac signal vectors.

2. The method of claim 1, wherein adjusting the cardiac resynchronization therapy comprises one or more of initiating the resynchronization therapy, terminating the resynchronization therapy, and altering one or more parameters of the resynchronization therapy.

3. The method of claim 1, comprising determining an angle of the one or more cardiac signal vectors, wherein adjusting the cardiac resynchronization therapy is based on the determined angle.

4. The method of claim 1, comprising determining a dominant orientation of the one or more cardiac signal vectors, wherein adjusting the cardiac resynchronization therapy is based on the dominant orientation.

5. The method of claim 1, comprising determining an angle of the one or more cardiac signal vectors, wherein adjusting the therapy comprises adjusting the therapy such that an angle of a dominant QRS vector moves in a direction of an angle of a baseline QRS vector.

6. The method of claim 1, comprising determining an angle of the one or more cardiac signal vectors, wherein adjusting the therapy comprises adjusting the therapy such that the determined angle moves toward a pre-determined vector angle.

7. The method of claim 6, further comprising selecting the pre-determined vector angle using patient-specific information.

8. The method of claim 1, comprising determining a first angle of the one or more cardiac signal vectors at a first time, and a second angle of the one or more cardiac signal vectors at a subsequent time, wherein adjusting the therapy comprises adjusting the therapy such that the magnitude of the difference between the first angle and second angle of the one or more cardiac signal vectors is smaller than a pre-determined threshold.

9. The method of claim 1, comprising:

determining a magnitude of cardiac asynchrony using the one or more cardiac signal vectors; and

adjusting the cardiac resynchronization therapy to reduce the magnitude of cardiac asynchrony.

10. The method of claim 1, comprising:

storing information associated with the one or more cardiac signal vectors;

performing a subsequent source separation providing updated vector information; and

comparing the updated vector information to the stored information to determine a level of cardiac asynchrony.

11. The method of claim 1, comprising:

determining a dominant orientation of the one or more cardiac signal vectors; and

comparing the dominant orientation to a baseline value,

wherein comparing the dominant orientation to the baseline value provides information related to the diagnosis of congestive heart failure in a patient.

12. The method of claim 1, comprising:

determining a dominant orientation of the one or more cardiac signal vectors; and

comparing the dominant orientation to a baseline value,

wherein comparing the dominant orientation to the baseline value provides information related to the progression of congestive heart failure in a patient.

13. The method of claim 1, comprising determining a patient'"'"'s response to the cardiac resynchronization therapy using the one or more cardiac signal vectors.

14. The method of claim 1, wherein adjusting the cardiac resynchronization therapy comprises recalculating one or more cardiac resynchronization therapy parameters and adjusting the cardiac resynchronization therapy using the recalculated one or more cardiac resynchronization therapy parameters.

15. The method of claim 1, wherein adjusting the cardiac resynchronization therapy comprises adjusting at least one of an inter-ventricular delay, an inter-atrial delay, an intra-ventricular delay, an atrial-ventricular delay, a stimulation site, a pacing chamber, a rate limiter, or a pacing mode.

16. The method of claim 1, wherein producing the one or more cardiac signal vectors comprises producing the cardiac signal vector associated with at least one complete cardiac signal cycle.

17. The method of claim 1, comprising one or more of storing the adjustments to the cardiac resynchronization therapy in a memory, communicating the adjustments to the cardiac resynchronization therapy to a patient-external device, and displaying the adjustments to the cardiac resynchronization therapy on a visual display.

18. A cardiac system, comprising:

a plurality of implantable electrodes configured for sensing a composite signal, thereby providing a plurality of composite signals;

a housing configured for implantation in a patient;

a controller provided in the housing and coupled to the plurality of implantable electrodes; and

a memory provided in the housing and coupled to the controller;

wherein the controller is configured to perform a source separation using the sensed plurality of composite signals, the source separation producing one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences, and to control a cardiac resynchronization therapy using the one or more cardiac signal vectors.

19. The system of claim 18, comprising a lead configured for subcutaneous non-intrathoracic placement in a patient and coupled to the controller, wherein at least one of the plurality of implantable electrodes is supported by the lead.

20. The system of claim 18, wherein at least one of the plurality of implantable electrodes is provided on the housing.

21. An implantable cardiac device, comprising:

means for sensing a plurality of composite cardiac signals using a plurality of implantable electrodes;

means for performing a source separation using the sensed plurality of composite cardiac signals, the source separation producing one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences; and

means for coordinating a cardiac resynchronization therapy using the one or more cardiac signal vectors.