Transition metal complexes with (pyridyl)imidazole ligands

• US 7,465,796 B2
• Filed: 02/24/2006
• Issued: 12/16/2008
• Est. Priority Date: 05/11/2001
• Status: Expired due to Term

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Inventors: Heller, Adam, Mao, Fei
• Primary Examiner(s): AULAKH, CHARANJIT
• Application Number:
  US11/361,427
• Publication Number:
  US 20060149067A1
• Time in Patent Office: 1,026 Days
• Field of Search: 546/2, 502/167, 204/403.14, 204/403.04
• US Class Current: 546/2
• CPC Class Codes: C07F 15/0026 without a metal-carbon linkage

Abstract

Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme-based electrochemical sensors. The transition metal complexes include substituted or unsubstituted (pyridyl)imidazole ligands. Transition metal complexes attached to polymeric backbones are also described.

Claims

1. A sensor control unit, comprising:

a housing adapted for placement on skin and adapted to receive a portion of an electrochemical sensor extending out of the skin having a plurality of contacts;

a plurality of conductive contacts disposed on the housing and configured for coupling to the plurality of contacts on the electrochemical sensor; and

an rf transmitter disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the electrochemical sensor,

wherein the electrochemical sensor comprises;

a working electrode;

a counter electrode;

an enzyme disposed proximate to the working electrode; and

a complex disposed proximate to the working electrode, the complex having the formula;

2. The sensor control unit of claim 1 wherein the complex is coupled to a polymeric backbone via at least one ligand selected from L, L′

, L₁ and L₂.

3. The sensor control unit of claim 2 wherein the polymeric backbone comprises at least one functional group that is a ligand of the complex.

4. The sensor control unit of claim 3 wherein the functional group is selected from pyridine and imidazole groups.

5. The sensor control unit of claim 1 wherein the complex is immobilized on the working electrode.

6. The sensor control unit of claim 1 wherein the complex and the enzyme are immobilized on the working electrode.

7. The sensor control unit of claim 1, further comprising adhesive for adhering the sensor control unit to skin.

8. The sensor control unit of claim 1, further comprising a mounting unit adapted for coupling with the housing.

9. The sensor control unit of claim 8, wherein the mounting unit is configured for placement between the housing and the skin of the patient.

10. The sensor control unit of claim 8, wherein adhesive is disposed on a surface of the mounting unit for adhering the mounting unit and housing to the skin of the patient.

11. The sensor control unit of claim 8, further comprising a support structure disposed on the mounting unit for aligning the contacts of the sensor with the conductive contacts of the sensor control unit.

12. The sensor control unit of claim 8, further comprising an opening in the mounting unit configured for guiding insertion of the electrochemical sensor into the patient.

13. The sensor control unit of claim 1, wherein the housing comprises a base and a cover.

14. The sensor control unit of claim 13, wherein the base and cover are configured to form a water resistant seal when coupled.

15. The sensor control unit of claim 1, wherein the housing is water resistant.

16. The sensor control unit of claim 1, wherein the conductive contacts are disposed on an interior surface of the housing.

17. The sensor control unit of claim 16, wherein the housing comprises a port adapted for penetration by the sensor.

18. The sensor control unit of claim 1, wherein the plurality of conductive contacts are disposed on an exterior surface of the housing.

19. The sensor control unit of claim 1, further comprising a battery disposed in the housing.