Diagnostic devices for use in the assaying of biological fluids
First Claim
1. In a lateral flow in-vitro diagnostic device comprising a housing, means in the housing to introduce a sample to be assayed in said device, means in said housing for fluid collection, and a backing strip having spaced apart first and second ends, the improvement comprising the backing strip having a surface with hydrophilic properties, said surface comprising either a hydrophilic heat-sealable adhesive or a hydrophilic pressure sensitive adhesive, wherein the adhesive increases the surface energy of a fluid flow path in the device and wherein the adhesive decreases the surface tension of a biological fluid flowing along the fluid flow path.
1 Assignment
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Accused Products
Abstract
Diagnostic in-vitro devices for use in the assaying of biological fluids are provided which include cover plates or backing strips which exhibit hydrophilic properties to assist in transport of the biological fluid or retention of same within the device. Exemplary diagnostic devices include lateral flow devices, microfluidic devices and microtiter plates. The devices may also be comprised of low fluorescent material in order to facilitate any diagnostic determination by use of fluorescent emissions. Hydrophilic properties may be imparted to the cover plates or backing strips by physical or chemical treatment thereof. The cover plates or backing strips may exhibit heat sealable or pressure sensitive properties.
31 Citations
26 Claims
- 1. In a lateral flow in-vitro diagnostic device comprising a housing, means in the housing to introduce a sample to be assayed in said device, means in said housing for fluid collection, and a backing strip having spaced apart first and second ends, the improvement comprising the backing strip having a surface with hydrophilic properties, said surface comprising either a hydrophilic heat-sealable adhesive or a hydrophilic pressure sensitive adhesive, wherein the adhesive increases the surface energy of a fluid flow path in the device and wherein the adhesive decreases the surface tension of a biological fluid flowing along the fluid flow path.
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24. A test device comprising:
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a backing strip having a first end, a second end laterally spaced from the first end, and a hydrophilic surface extending between the laterally spaced first and second ends, the hydrophilic surface comprising a hydrophilic adhesive; fluid accepting means positioned overlying the first end of the backing strip; and fluid absorbing means positioned overlying the second end of the backing strip, wherein the hydrophilic adhesive is either a pressure sensitive adhesive or a heat sealable adhesive that increases the surface energy of a fluid flow path in the device and decreases the surface tension of a biological fluid flowing along the fluid flow path, and wherein the device is configured such that a fluid containing water introduced to the fluid accepting means flows laterally along the hydrophilic surface of the backing strip to the fluid absorbing means. - View Dependent Claims (25, 26)
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Specification