Allograft implant

• US 7,491,237 B2
• Filed: 03/28/2005
• Issued: 02/17/2009
• Est. Priority Date: 03/26/2004
• Status: Active Grant

• Current Assignee: Synthes USA LLC (Johnson & Johnson)
• Original Assignee: Synthes USA LLC (Johnson & Johnson)
• Inventors: Messerli, Dominique, Angelucci, Christopher M, Goodwin, Roger D, Delurio, Robert J, Boyer, Michael L II, Randall, Brandon L, Myer, Jacqueline
• Primary Examiner(s): Willse; Dave
• Assistant Examiner(s): Blanco; Javier G
• Application Number:
  US11/093,111
• Publication Number:
  US 20050240267A1
• Time in Patent Office: 1,422 Days
• Field of Search: 623/17.11
• US Class Current: 623/17.11
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/3094 Designing or manufacturing processes
• CPC Class Codes: A61F 2/44 for the spine, e.g. vertebrae, spinal discs
• CPC Class Codes: A61F 2/4455 for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages intervertebral discs A61F2/442
• CPC Class Codes: A61F 2/4611 of spinal prostheses
• CPC Class Codes: A61F 2002/2835 Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
• CPC Class Codes: A61F 2002/30057 made from both cortical and cancellous adjacent parts
• CPC Class Codes: A61F 2002/30266 wedge-shaped parallelepipeds
• CPC Class Codes: A61F 2002/30383 made by laterally inserting a protrusion, e.g. a rib into a complementarily-shaped groove
• CPC Class Codes: A61F 2002/30387 Dovetail connection
• CPC Class Codes: A61F 2002/30492 using a locking pin
• CPC Class Codes: A61F 2002/30507 using a threaded locking member, e.g. a locking screw or a set screw
• CPC Class Codes: A61F 2002/30571 Leaf springs
• CPC Class Codes: A61F 2002/30604 modular
• CPC Class Codes: A61F 2002/30617 Visible markings for adjusting, locating or measuring
• CPC Class Codes: A61F 2002/30782 inclined obliquely
• CPC Class Codes: A61F 2002/30795 Blind bores, e.g. of circular cross-section
• CPC Class Codes: A61F 2002/3082 Grooves
• CPC Class Codes: A61F 2002/30843 Pyramidally-shaped
• CPC Class Codes: A61F 2002/30904 serrated profile, i.e. saw-toothed
• CPC Class Codes: A61F 2002/4622 : having the shape of a forceps or a clamp
• CPC Class Codes: A61F 2002/4628 : with linear motion along or rotating motion about an axis transverse to the instrument axis or to the implantation direction, e.g. clamping
• CPC Class Codes: A61F 2002/4629 : connected to the endoprosthesis or implant via a threaded connection
• CPC Class Codes: A61F 2220/0025 : Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
• CPC Class Codes: A61F 2230/0082 : parallelepipedal
• CPC Class Codes: A61F 2250/0097 : Visible markings, e.g. indicia
• CPC Class Codes: A61F 2310/00359 : Bone or bony tissue

Abstract

An allogenic implant for use in intervertebral fusion is formed from one or more two pieces. The pieces are made from bone, and are joined together to form an implant having sufficient strength and stability to maintain a desired distance between first and second vertebrae in a spinal fusion procedure. The implant pieces may be formed of cortical bone and connected by dovetail joints, and at least one cortical bone pin may be provided to lock the pieces together and to add strength to the implant. Teeth are formed on the vertebra engaging surfaces of the implant prevent short-term slippage of the implant.

Claims

1. A multipiece implant comprising:

a body having a superior surface, an inferior surface and a surface extending from the superior surface to the inferior surface, the body further including a central opening extending from the superior surface to the inferior surface for receiving one of osteogenic, osteoconductive or osteoinductive material;

the body being formed from at least first and second mating cortical bone segments, each segment having a locking surface configured to engage the locking surface of the other segment, each segment including at least a portion of the superior and inferior surfaces of the body and at least two passages, the first and the second cortical bone segments being arranged so that, when mated, the passages are in registry and have a common axis;

at least two cortical bone pins disposed within the passages;

wherein the locking surfaces of the first and second bone segments form dovetail joints, each of the dovetail joints including a mortise and a tenon, each of the passages passing through one of the mortises and tenons so that the cortical bone pins pass through one of the mortises and tenons;

and wherein the passages are configured so that the bone pins are positioned on opposite sides of the central opening.

2. The multipiece implant of claim 1, wherein the superior and inferior surfaces of each cortical bone segment comprise a plurality of teeth.

3. The multipiece implant of claim 2, wherein the teeth are arranged in a two dimensional array, and at least some of the teeth have a pyramidal shape.

4. The multipiece implant of claim 1, wherein the superior surface has a substantially convex curvature.

5. The multipiece implant of claim 4, wherein the inferior surface has a substantially convex curvature.

6. The multipiece implant of claim 5, wherein the curvature of the superior surface lies in an anterior-posterior plane, and the curvature of the inferior surface lies in a medial-lateral plane.

7. The multipiece implant of claim 4, wherein the superior and inferior surfaces each comprise a series of teeth.

8. The multipiece implant of claim 7, wherein the teeth are arranged in a two dimensional array, and the teeth have a pyramidal shape.

9. The multipiece implant of claim 1, the implant further comprising an anterior-posterior axis, the at least two passages being aligned substantially parallel to the anterior-posterior axis.

10. The multipiece implant of claim 1, the implant further comprising an anterior-posterior axis, wherein the at least two passages are non-parallel to the anterior-posterior axis.

11. The multipiece implant of claim 10, wherein an angle between the at least two passages and the anterior-posterior axis is between about 9 degrees to about 18 degrees.

12. The multipiece implant of claim 1, wherein the at least two passages each include an abutting surface configured to engage an end surface of the cortical pins.

13. The multipiece implant of claim 12, the first and second bone segments comprising an anterior bone segment and a center bone segment, respectively the implant further comprising a posterior bone segment engaged to the center bone segment via a dovetail joint, wherein the abutting surface is located in the posterior bone segment so that when the implant is placed between vertebral end plates of a patient, the pins are thereafter prevented from migrating in the posterior direction.

14. The multipiece implant of claim 12, the first and second bone segments comprising an anterior bone segment and a center bone segment, the implant further comprising a posterior bone segment engaged to the center bone segment via a dovetail joint, wherein the abutting surface is located in the anterior bone segment so that when the implant is placed between vertebral end plates of a patient, the pins are thereafter prevented from migrating in the anterior direction.

15. The multipiece implant of claim 1, wherein the at least one mortise has a first engaging face and the at least one tenon has a second engaging face which, when the mortise and tenon are oriented as when engaged, is not parallel to the first engaging face.

16. The multipiece implant of claim 15, wherein, when the mortise and the tenon oriented as when engaged, the first and second engaging faces define an angle of about 2 degrees.

17. The multipiece implant of claim 1, wherein the at least two cortical bone pins do not intersect either of the superior and inferior surfaces.

18. A multipiece intervertebral implant for implantation between first and second vertebrae, the implant comprising:

a first segment constructed of cortical bone and having a first coupling portion;

a second segment constructed of cortical bone and having second and third coupling portions; and

a third segment constructed of cortical bone and having a fourth coupling portion;

wherein the first and second segments are joined together by interfitting the first and second coupling portions and wherein the second and third segments are joined together by interfitting the third and fourth coupling portions to form a single body, the single body including a superior surface, an inferior surface and a surface extending from the superior surface to the inferior surface, the single body further including a central opening extending from the superior surface to the inferior surface;

wherein the first and second coupling portions and the third and fourth coupling portions are dovetail joints, each of the dovetail joints including a corresponding mortise and tenon; and

wherein each bone segment forms at least a portion of the superior surface and at least a portion of the inferior surface; and

wherein the single body includes a first bore extending at least partially through each of the first, second, and third bone segments and a second bore extending at least partially through each of the first, second, and third bone segments, the first and second bores being configured to receive first and second bone pins, respectively, the first and second bone pins being arranged so that the first and second bone pins do not intersect the central opening;

the first bone pin positioned on one side of the central opening and the second bone pin positioned on an opposite side of the central opening, each of the first and second bone pins passing through one of the mortises and tenons.

19. The multipiece implant of claim 18, wherein the superior surface is convexly curved.

20. The multipiece implant of claim 18, wherein the inferior surface is substantially flat.

21. The multipiece implant of claim 18, wherein the central opening has a substantially larger diameter than each of the first and second bores.

22. The multipiece implant of claim 18, wherein at least one of the first, second, and third bone segments is at least partially demineralized.

23. The multipiece implant of claim 18, wherein at least a portion of the implant comprises teeth having a pyramidal shape.

24. The multipiece implant of claim 18, wherein the first and second bores extend completely through each of the first, second, and third bone segments.

25. The multipiece implant of claim 18, wherein the first and second bores extend only partially through at least one of the bone segments.

26. The multipiece implant of claim 18, the implant further comprising an anterior posterior axis, wherein an angle between the axis of the first and second bores and the anterior-posterior axis is between about 12 degrees to about 18 degrees.

27. The multipiece implant of claim 18, wherein the central opening is partially formed in the first segment and partially formed in the second segment.

28. The multipiece implant of claim 18, wherein the first and second bone pins do not intersect either of the superior and inferior surfaces.