Benzisoxazole piperazine compounds and methods of use thereof

• US 7,494,998 B2
• Filed: 04/26/2006
• Issued: 02/24/2009
• Est. Priority Date: 04/26/2005
• Status: Expired due to Fees

• Current Assignee: Hypnion, Inc.
• Original Assignee: Hypnion, Inc.
• Inventors: White, James F., Hangauer, David G., Coughlin, Daniel, Solomon, Michael, Edgar, Dale M., Shiosaki, Kazumi
• Primary Examiner(s): Wilson; James O
• Assistant Examiner(s): Leeser; Erich A
• Application Number:
  US11/412,856
• Publication Number:
  US 20070004752A1
• Time in Patent Office: 1,035 Days
• Field of Search: 544/368, 514/254.02
• US Class Current: 514/254.02
• CPC Class Codes: A61P 25/20 Hypnotics; Sedatives
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07D 261/20 condensed with carbocyclic rings or ring systems
• CPC Class Codes: C07D 413/04 directly linked by a ring-member-to-ring-member bond

Abstract

The invention includes benzisoxazole piperazine compositions and methods of using them for modulating sleep.

Claims

1. A compound having the formula of Compound 1:

2. A pharmaceutical composition comprising the compound, or pharmaceutically acceptable salt thereof, of claim 1 and at least one pharmaceutically acceptable excipient.

3. A method of treatment of insomnia in a subject, comprising administering to a subject in need of thereof a therapeutically effective amount of a composition of claim 2.

4. The method of claim 3, wherein the subject is a human.

5. The salt of claim 1 which is the monohydrochloride salt.

6. The composition of claim 2 in which the pharmaceutically acceptable salt is the monohydochloride salt.