Methods and compositions for increasing the anaerobic working capacity in tissues

• US 7,504,376 B2
• Filed: 11/18/2003
• Issued: 03/17/2009
• Est. Priority Date: 08/12/1996
• Status: Expired due to Term

• Current Assignee: Natural Alternatives International Incorporated (Natural Alternatives LLC)
• Original Assignee: Natural Alternatives Int'l Incorporated
• Inventors: Dunnett, Mark, Harris, Roger
• Primary Examiner(s): Henley, III; Raymond J
• Application Number:
  US10/717,217
• Publication Number:
  US 20040229773A1
• Time in Patent Office: 1,946 Days
• Field of Search: None
• US Class Current: 514/1.1
• CPC Class Codes: A23L 33/175 Amino acids
• CPC Class Codes: A23P 10/40 free-flowing powder or instant powder, i.e. powder which is reconstituted rapidly when liquid is added A23P10/20, A23P10/30 take precedence
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/155 Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
• CPC Class Codes: A61K 31/175 having the group , >N—C(O)—N=N— or , e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
• CPC Class Codes: A61K 31/195 having an amino group
• CPC Class Codes: A61K 31/197 the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid carnitine A61K31/205
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 31/385 having two or more sulfur atoms in the same ring
• CPC Class Codes: A61K 31/415 1,2-Diazoles
• CPC Class Codes: A61K 31/4172 Imidazole-alkanecarboxylic acids, e.g. histidine
• CPC Class Codes: A61K 31/44 Non condensed pyridines; Hydrogenated derivatives thereof
• CPC Class Codes: A61K 38/05 Dipeptides
• CPC Class Codes: A61K 38/28 Insulins
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 9/0053 Mouth and digestive tract, i.e. intraoral and peroral administration rectal administration A61K9/0031
• CPC Class Codes: A61P 21/00 Drugs for disorders of the muscular or neuromuscular system
• CPC Class Codes: A61P 21/06 Anabolic agents androgens A61P5/26
• CPC Class Codes: A61P 3/02 Nutrients, e.g. vitamins, minerals
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The invention provides compositions comprising beta-alanylhistidine peptides and beta-alanines, and methods for administering these peptides and amino acids. In one aspect, the compositions and methods cause an increase in the blood plasma concentrations of beta-alanine and/or creatine.

Claims

1. A composition, comprising:

glycine; and

a) an amino acid selected from the group consisting of a beta-alanine, an ester of a beta-alanine, and an amide of a beta-alanine, or

b) a di-peptide selected from the group consisting of a beta-alanine di-peptide and a beta-alanylhistidine di-peptide.

2. The composition of claim 1, wherein the beta-alanylhistidine dipeptide is a carnosine, an anserine or a balenine.

3. The composition of claim 1, further comprising at least creatine or a carbohydrate.

4. The composition of claim 1, wherein the composition is a pharmaceutical composition.

5. The composition of claim 1, wherein the composition is a dietary supplement or a sports drink.

6. The composition of claim 5, wherein the dietary supplement or sports drink is a supplement for humans.

16. The composition of claim 1, wherein the composition is formulated for oral, enteral or parenteral administration.

17. The composition of claim 1, wherein the composition is formulated for infusion through the skin of a subject.

18. The composition of claim 17, wherein the composition is a topical cream or a patch.

7. A composition comprising at least 0.2, 0.3, 0.4, 0.5, 1.0, 1.5, 2.0, 2.5, 3.0, 3.5, 4.0, 4.5 or 5 grams of a peptide or an ester comprising a beta-alanine per dosage.

9. The composition of claim 7 or claim 8, wherein the peptide comprises a beta-alanylhistidine dipeptide.

10. The composition of claim 9, wherein the beta-alanylhistidine dipeptide comprises a carnosine, an anserine or a balenine.

8. A composition comprising at least 0.2, 0.3, 0.4, 0.5, 1.0, 1.5, 2.0, 2.5, 3.0 grams of a peptide or an ester comprising a beta-alanine in an injectable form per dosage.

11. A composition for humans comprising at least 200, 250, 300, 450, 500, 550, 600, 650, 700, 750 or 800 mg of a beta-alanine per dosage.

12. The composition of claim 11, wherein the composition is formulated in an ingestible or an injectable formulation.

13. The composition of claim 12, wherein the ingestible formulation is a drink, a gel, a food or a tablet.

14. The composition of claim 11, wherein the peptide comprises a beta-alanylhistidine dipeptide.

15. The composition of claim 13, wherein the beta-alanylhistidine dipeptide comprises a carnosine, an anserine or a balenine.