Pressure pulse/shock wave therapy methods for organs

  • US 7,507,213 B2
  • Filed: 09/29/2005
  • Issued: 03/24/2009
  • Est. Priority Date: 03/16/2004
  • Status: Active Grant
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First Claim
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1. An invasive method of stimulating an organ having tissue made of cellular matter comprises the steps of:

  • exposing an organ by an invasive or open surgical procedure to provide an at least partial exposed organ or an access portal to an organ;

    activating an acoustic pressure pulse shock wave generator or source to emit a pressure pulse or acoustic shock waves from a shock wave head, the pressure pulse being an acoustic pulse which includes several cycles of positive and negative pressure, wherein the pressure pulse has an amplitude of the positive part of such a cycle should be above 0.1 MPa and the time duration of the pressure pulse is from below a microsecond to about a second, rise times of the positive part of the first pressure cycle in the range of nano-seconds (ns) up to some milli-seconds (ms), the acoustic shock waves being very fast pressure pulses having amplitudes above 0.1 MPa and rise times of the amplitude being below 100'"'"'s of ns, the duration of the shock wave is typically below 1-3 micro-seconds (μ

    s) for the positive part of a cycle and typically above some micro-seconds for the negative part of a cycle; and

    wherein the shock wave head is directed to enter either the access portal or an opening wherein the organ is at least partially exposed to permit entry of the shock wave head directly to the organ; and

    subjecting the organ to convergent, divergent, planar or near planar acoustic shock waves or pressure pulses in the absence of a focal point impinging the organ stimulating a cellular response in the absence of creating cavitation bubbles evidenced by not experiencing the sensation of hemorrhaging caused by the emitted waves or pulses in the tissue of said organ wherein the organ is positioned within an unobstructed path of the emitted shock waves or pressure pulses without interfering tissue or skeletal bone mass; and

    away from any localized geometric focal volume or point of the emitted shock waves wherein the emitted shock waves or pressure pulses either have no geometric focal volume or point or have a focal volume or point ahead of the tissue or beyond the tissue thereby passing the emitted waves or pulses through the tissue while avoiding having any localized focal point within the tissue of the organ wherein the emitted pressure pulses or shock waves are convergent, divergent, planar or near planar and the pressure pulse shock wave generator or source is based on electro-hydraulic, electromagnetic, piezoceramic or ballistic wave generation having an energy density value ranging as low as 0.00001 mJ/mm2 to a high end of below 1.0 mJ/mm2; and

    wherein the organ is a heart, a liver or a kidney or a portion of a brain or any other organ or portion thereof; and

    wherein the shock wave head is internally directed in contact or near contact with the exposed organ directly or through a coupling gel or oil or coupling medium.

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