Detection of analytes using reorganization energy
First Claim
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1. A method of detecting a target analyte in a test sample comprising:
- a) adding a target analyte to an electrode comprising;
i) a redox active molecule with a first E0, said redox active molecule comprising a metal selected from the group consisting of manganese, technetium, rhenium, iron, ruthenium, osmium, cobalt, rhodium, iridium, nickel, palladium, platinum, copper, silver and gold; and
ii) a binding ligand that will bind said target analyte;
such that upon binding of said target analyte to said binding ligand a redox active complex with a second different E0 is formed; and
b) measuring said second E0 as an indication of the presence of said target analyte.
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Abstract
The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process.
98 Citations
28 Claims
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1. A method of detecting a target analyte in a test sample comprising:
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a) adding a target analyte to an electrode comprising; i) a redox active molecule with a first E0, said redox active molecule comprising a metal selected from the group consisting of manganese, technetium, rhenium, iron, ruthenium, osmium, cobalt, rhodium, iridium, nickel, palladium, platinum, copper, silver and gold; and ii) a binding ligand that will bind said target analyte;
such that upon binding of said target analyte to said binding ligand a redox active complex with a second different E0 is formed; andb) measuring said second E0 as an indication of the presence of said target analyte. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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Specification