Low frequency vibration assisted blood perfusion emergency system

• US 7,517,328 B2
• Filed: 07/30/2004
• Issued: 04/14/2009
• Est. Priority Date: 09/04/2003
• Status: Expired due to Fees

• Current Assignee: 3921093 Canada Inc., Parallel Biotechnologies, LLP
• Original Assignee: Ahof Biophysical Systems Inc.
• Inventors: Hoffmann, Andrew Kenneth
• Primary Examiner(s): Brown; Michael A.
• Application Number:
  US10/902,122
• Publication Number:
  US 20050054958A1
• Time in Patent Office: 1,719 Days
• Field of Search: 601/46, 601/48, 601/49, 601 55- 56, 601/77, 601148-152
• US Class Current: 601/46
• CPC Class Codes: A61B 17/225 for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
• CPC Class Codes: A61H 1/00 Apparatus for passive exercising A61H5/00 takes precedence; Vibrating apparatus; Chiropractic devices, e.g. body impacting devices, external devices for briefly extending or aligning unbroken bones
• CPC Class Codes: A61H 2023/0209 powered with frequencies not related to mains frequency
• CPC Class Codes: A61H 2201/5043 Displays
• CPC Class Codes: A61H 2201/5061 Force sensors
• CPC Class Codes: A61H 31/00 Artificial respiration or heart stimulation, e.g. heart massage artificial respiration by treatment with gas or air, e.g. mouth-to-mouth respiration A61M16/00; applying electric currents by contact electrodes for stimulation, e.g. heart pace-makers A61N1/36 ; teaching or training models, demonstration models for medical purposes G09B23/288
• CPC Class Codes: A61H 31/005 with feedback for the user
• CPC Class Codes: A61H 31/006 Power driven
• CPC Class Codes: A61P 7/02 Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Abstract

An emergency system for treatment of a patient (20) experiencing an acute vascular obstruction, employing a non-invasive vibrator (10), optimally in conjunction with drugs, for disrupting and lysing thromboses, relieving spasm (if associated), and thereby restoring blood perfusion. Vibrator (10) is operable in the sonic to infrasonic range, with a source output of up to 15 mm. For acute myocardial infarction cases, a pair of contacts (12), are advantageously placed to bridge the sternum at the fourth intercostal space. Vibration is initiated at 50 Hz (or any frequency, preferably within the 20-120 Hz range), and is ideally adjusted to a maximal amplitude (or force) deemed tolerable and safe to the patient (20), preferably with the administration of thrombolytic agents or other form of drug therapy. A synergistic effect is achieved between vibration and drugs to facilitate the disruption of thromboses, relieve spasm, and restore blood perfusion. In a variation, ultrasonic imaging may be used to direct vibration therapy.

Claims

1. An emergency method of using a percussion device operable to emit non-invasive localized mechanical percussion at a frequency in the infrasonic to sonic range for enhancing intravenously administered thrombolytic drug action in clearance of an acute thrombotic arterial obstruction within a patient, comprising the steps of:

a) applying non-invasive localized low frequency mechanical percussion at a frequency between 1 Hz-1000 Hz and a stroke length between 0.1-10 mm from said percussion device upon a targeted external body surface deemed proximate said acute thrombotic arterial obstruction, and

b) intravenously administering a thrombolytic drug to said patient, prior to completion of step 260 (a),

whereby said percussion device is placed in direct mechanical contact with said targeted external body surface, and

whereby said non-invasive localized low frequency mechanical percussion concurrently accelerates the action of said intravenously administered thrombolytic drug in the emergency clearance of said acute thrombotic arterial obstruction.

2. The method of claim 1, wherein said acute thrombotic arterial obstruction comprises an acute coronary thrombotic obstruction.

3. The method of claim 1 wherein said percussion is applied in the sonic frequency range.

4. The method of claim 1, wherein said percussion is applied at a stroke length of at least 1 mm.

5. The method of claim 4, further comprising the step of adjusting the stroke length of said percussion after step 260 (a) has been initiated, such as to match a tolerance level of said patient to optimize the delivery of said percussion.

6. The method of claim 1, wherein said percussion is applied to at least one of the chest wall and the upper back of said patient, in acute coronary thrombosis applications.

7. The method of claim 6, wherein said percussion is exclusively administered during the diastolic period of the cardiac cycle of said patient.

8. The method of claim 1, wherein said percussion is applied to at least one of the head and neck of said patient, in acute ischemic stoke applications.

9. The method of claim 1, wherein said acute thrombotic arterial obstruction comprises an acute thrombotic cerebral vascular obstruction.

10. The method of claim 1, wherein said percussion is delivered at a frequency of less than or equal to 150 Hz.

11. A method of using a non-invasive vibrator administrable to emit vibration in the infrasonic to sonic frequency range to enhance the efficacy of a thrombolytic drug in the remediation of an acutely thrombosed artery, comprising the steps of intravenously administering said thrombolytic drug to a patient experiencing said acutely thrombosed artery, and applying non-invasive, transcutaenous localized mechanical vibration having a frequency of between 1 Hz to 1000 Hz and a displacement amplitude of between 0.1 mm to 10 mm via said vibrator placed in immediate contact upon a targeted external body surface deemed proximate said thrombosed artery in combination with said thrombolytic drug, in order to improve the effectiveness of said thrombolytic drug towards remediation of said thrombosed artery.

12. The meted of claim 11, wherein said thrombosed artery comprises at least one of a coronary and a cerebral artery.

13. The method of claim 11, wherein said vibration is applied at a frequency of at least 20 Hz.

14. The method of claim 11, wherein said vibration has a displacement amplitude in the range of 1 mm-10 mm, such as to promote penetration of said vibration.

15. The method of claim 11, wherein said vibration has a waveform selected from at least one of:

a sinusoidal waveform, a substantially square or percussive wave form, a saw-tooth waveform, an exponential waveform, a substantially linear waveform, a curved waveform, and combinations thereof.

16. The method of claim 11, wherein said vibration is applied to at least one of the chest wall and upper back, in coronary applications.

17. The method of claim 11, wherein said vibration is applied to at least one of the neck and the cranium, in acute ischemic stroke applications.

18. The method of claim 11, wherein said vibration has a frequency in the range of 20 Hz-120 Hz.

19. An emergency method for enhancing fibrinolytic clot disruptive drug efficacy in the dissolution of a blood clot within an acutely thrombosed artery, comprising the steps of:

a) intravenously administering a fibrinolytic drug to a patient deemed to be experiencing an acutely thrombosed artery, and

b) applying non-invasive sonic vibration at a frequency of less than 1000 Hz and a stroke length in the range of 0.1 mm to 10 mm to said patient in combination with said fibrinolytic drug,

whereby the source of said vibration is placed in immediate contact with said patient, and

whereby said vibration assists the action of said fibrinolytic drug towards the dissolution of said blood clot within said acutely thrombosed artery.

20. The method of claim 19, wherein said acutely thrombosed artery obstructs blood flow to a vital internal organ.

21. The method of claim 19, wherein said vibration is applied at a frequency of less than or equal to 50 Hz.

22. An emergency method of using a non-invasive low frequency vibrator operable to emit vibration within the infrasonic to sonic frequency range to enhance the efficacy of a fibrinolytic drug in the restoration of blood flow of an acutely thrombosed coronary artery, comprising the steps of intravenously administering a fibrinolytic drug to a patient experiencing an acutely thrombosed coronary artery, and applying localized transthoracic vibration having a frequency less than 1000 Hz and a displacement amplitude in the range of 1 mm to 10 mm via said vibrator placed in direct mechanical contact upon a targeted external body surface overlying the thoracic cavity of said patient generally proximate the heart in combination with said fibrinolytic drug, in order to improve the effectiveness of said fibrinolytic drug towards the emergency restoration of blood flow of said acutely thrombosed coronary artery.

23. The method of claim 22, wherein said vibration is applied in the sonic frequency range.

24. The method of claim 22, wherein said vibration is applied to at least one of the chest wall and upper back of a patient receiving said vibration, in treatment of acute ST elevation myocardial infarction.

25. The method of claim 22, further comprising the step of a) delivering said vibrator to said patient prior to said intravenously administering a fibrinolytic drug and then transporting said patient to a treatment facility concurrently with said applying localized transthoracic vibration in conjunction with said fibrinolytic drug, whereby said vibrator is used in the field.

26. The method of claim 22, wherein said vibration is applied when said patient is hemodynamically stable.

27. The method of claim 22, wherein said vibration is applied exclusively during the diastolic phase of a cardiac cycle.

28. The method of claim 27, wherein said vibration is applied during the diastolic phase of a cardiac cycle wherein said patient is in one of heart failure or cardiogenic shock.

29. The method of claim 22, wherein said vibration has a displacement amplitude greater than 2 mm, such as to ensure tranathoracic penetration of said vibration.

30. The method of claim 22, wherein said vibration has a frequency of less than or equal to 200 Hz.