Differentially coated stent

• US 7,540,880 B2
• Filed: 11/02/2006
• Issued: 06/02/2009
• Est. Priority Date: 01/24/2003
• Status: Expired due to Fees

• Current Assignee: Medtronic Vascular, Inc. (Medtronic Plc)
• Original Assignee: Medtronic Vascular, Inc. (Medtronic Plc)
• Inventors: Nolting, John
• Primary Examiner(s): GHERBI, SUZETTE JAIME J
• Application Number:
  US11/555,845
• Publication Number:
  US 20070061007A1
• Time in Patent Office: 943 Days
• Field of Search: 623 142- 148
• US Class Current: 623/1.15
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2002/91541 Adjacent bands are arranged out of phase
• CPC Class Codes: A61F 2002/91558 connected peak to peak
• CPC Class Codes: A61F 2230/0013 Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61L 2300/61 containing two or more active agents in different layers
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: Y10S 623/901 Method of manufacturing prosthetic device

Abstract

A stent is differentially coated to accommodate areas of high strain. A therapeutic coating is applied to only those areas of the stent that do not experience high strain. This allows a therapeutic coating to be chosen for its elution characteristics, for example, rather than for its ability to withstand high strain. An elastic coating may be applied to the areas of high strain. The elastic coating may or may not include a therapeutic agent.

Claims

1. A method of manufacturing a differentially coated stent, comprising:

providing a stent framework, the stent framework including areas of high strain;

masking the high strain areas of the stent framework;

applying a therapeutic coating to the unmasked stent framework;

removing the mask from the masked high strain areas of the stent framework;

masking the areas of the stent framework having the therapeutic coating; and

applying an elastic coating to the unmasked high-strain areas of the stent framework.

2. The method of claim 1 wherein the high strain areas of the stent framework are masked by one or more materials selected from a group consisting of a tetrafluorethylene sleeve, an adhesive-backed material, and a removable polymeric coating.

3. The method of claim 1 wherein the therapeutic coating is applied by a method selected from the group consisting of pad printing, inkjet printing, rolling, painting, spraying, micro-spraying, dipping, wiping, electrostatic deposition, vapor deposition, epitaxial growth, and combinations thereof.

4. The method of claim 1 wherein the elastic coating is applied by a method selected from the group consisting of pad printing, inkjet printing, rolling, painting, spraying, micro-spraying, dipping, wiping, electrostatic deposition, vapor deposition, epitaxial growth, and combinations thereof.

5. The method of claim 1 wherein the therapeutic coating comprises a first polymer and the elastic coating comprises a second polymer.

6. The method of claim 1 wherein the therapeutic coating includes a therapeutic agent selected from a group consisting of an antineoplastic agent, an antiproliferative agent, an antibiotic, an antithrombogenic agent, an anticoagulant, an antiplatelet agent, and an anti-inflammatory agent.

7. The method of claim 1 wherein the elastic coating includes a therapeutic agent selected from a group consisting of an antineoplastic agent, an antiproliferative agent, an antibiotic, an antithrombogenic agent, an anticoagulant, an antiplatelet agent, and an anti-inflammatory agent.

8. The method of claim 7 wherein the therapeutic coating and the elastic coating display different elution characteristics.

9. The method of claim 1 wherein the therapeutic coating includes a first therapeutic agent and the elastic coating includes a second therapeutic agent.

10. The method of claim 9 wherein the therapeutic coating and the elastic coating display different elution characteristics.

11. The method of claim 1 wherein the therapeutic coating and the elastic coating display different durability characteristics.

12. The method of claim 1 wherein the elastic coating is a polymer selected from a group consisting of, urethane, polycaprolactone (PCL), polybutylmethacrylate (PBMA), polyethylenevinyl acetate (PEVA), combinations and/or copolymers of the above.

13. A differentially coated stent, the stent comprising:

a stent framework, the stent framework including a plurality of high strain areas and a plurality of low strain areas, each low strain area adjacent to at least one high strain area;

an elastic coating disposed on each of the plurality of high strain areas; and

a therapeutic coating disposed on each of the plurality of low strain areas.

14. The stent of claim 13 wherein the therapeutic coating includes a therapeutic agent selected from a group consisting of an antineoplastic agent, an antiproliferative agent, an antibiotic, an antithrombogenic agent, an anticoagulant, an antiplatelet agent, and an anti-inflammatory agent.

15. The stent of claim 13 wherein the elastic coating includes a therapeutic agent, the therapeutic agent selected from a group consisting of an antineoplastic agent, an antiproliferative agent, an antibiotic, an antithrombogenic agent, an anticoagulant, an antiplatelet agent, and an anti-inflammatory agent.

16. The stent of claim 15 wherein the therapeutic coating and the elastic coating display different elution characteristics.

17. The stent of claim 15 wherein the therapeutic coating includes a first therapeutic agent and the elastic coating includes a second therapeutic agent, the first therapeutic agent different than the second therapeutic agent.

18. The stent of claim 17 wherein the first therapeutic agent of the therapeutic coating and the second therapeutic agent of the elastic coating display different elution characteristics.

19. The stent of claim 13 wherein the therapeutic coating and the elastic coating display different durability characteristics.

20. The stent of claim 13 wherein the elastic coating is a polymer selected from a group consisting of, urethane, polycaprolactone (PCL), polybutylmethacrylate (PBMA), polyethylenevinyl acetate (PEVA), combinations and/or copolymers of the above.