Tet repressor-based transcriptional regulatory proteins

  • US 7,541,446 B2
  • Filed: 06/05/2003
  • Issued: 06/02/2009
  • Est. Priority Date: 06/07/1999
  • Status: Expired due to Term
First Claim
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1. An isolated polynucleotide selected from the group consisting of:

  • (a) a polynucleotide having the nucleic acid sequence as shown in SEQ ID No;


    (b) a polynucleotide encoding a first polypeptide, wherein the first polypeptide differs from the polypeptide encoded by SEQ ID NO;

    5 by a single amino acid, wherein the amino acid difference is S12G;

    (c) a polynucleotide having a nucleic acid sequence which differs from the nucleic acid sequence of (a) due to the degeneracy of the genetic code;

    wherein the polypeptide encoded by each of the polynucleotides (a), (b), and (c) is capable of inducing transcriptional activity in the presence of tetracycline, tetracycline derivatives, or tetracycline analogs in a host cell.

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