Comprehensive pharmacologic therapy for treatment of a dysfunction

• US 7,547,723 B2
• Filed: 06/20/2005
• Issued: 06/16/2009
• Est. Priority Date: 10/04/1999
• Status: Expired due to Fees

• Current Assignee: Martin C Hinz
• Original Assignee: Martin C Hinz
• Inventors: Hinz, Martin C.
• Primary Examiner(s): Richter; Johann R
• Assistant Examiner(s): LEA, CHRISTOPHER RAYMOND
• Application Number:
  US11/157,198
• Publication Number:
  US 20050233008A1
• Time in Patent Office: 1,457 Days
• Field of Search: None
• US Class Current: 514/419
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/135 having aromatic rings , e.g. ketamine, nortriptyline methadone A61K31/137
• CPC Class Codes: A61K 31/195 having an amino group
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 31/34 having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
• CPC Class Codes: A61K 31/343 condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
• CPC Class Codes: A61K 31/375 Ascorbic acid, i.e. vitamin C; Salts thereof
• CPC Class Codes: A61K 31/405 Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
• CPC Class Codes: A61K 31/44 Non condensed pyridines; Hydrogenated derivatives thereof
• CPC Class Codes: A61K 31/4415 Pyridoxine, i.e. Vitamin B6 pyridoxal phosphate A61K31/675
• CPC Class Codes: A61K 33/06 Aluminium, calcium or magnesium; Compounds thereof , e.g. clay
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents

Abstract

The comprehensive pharmacologic therapy for treatment of obesity is a procedure which involves the administration of a desired therapeutic range of Diethylpropion and/or Phentermine in combination with a SSRI medication and nutritional supplementation for brief and long durations which may be 12 months or more. The preferred procedure involves the administration of drugs in combination which are identified as: Citalopram (Celexa) and Phentermine; Citalopram (Celexa) and Diethylpropion; Citalopram (Celexa), Phentermine, and Diethylpropion. In addition nutritional supplementation such as a multivitamin, 5-Hydroxytryptophan, vitamin B6, vitamin C, Tyrosine, Calcium, and Lysine may be used to enhance the performance of the weight loss treatment program.

Claims

1. A method to facilitate weight loss for a patient not suffering from depression, said method comprising:

a. administration of 5-hydroxytryptophan;

b. administration of tyrosine wherein said 5-hydroxytryptophan and said tyrosine are administered in an effective therapeutic range to effectuate said weight loss.

2. The method according to claim 1, said effective therapeutic range comprising:

a. administration of at least of 50 mg of 5-hydroxytryptophan each day; and

b. administration of at least of 50 mg of tyrosine each day.

3. The method according to claim 2, said effective therapeutic range further comprising:

a. administration of not more than 900 mg of 5-hydroxytryptophan each day; and

b. administration of not more than 4000 mg of tyrosine each day.

4. The method according to claim 3, further comprising the administration of at least 2 mg of vitamin B6 each day.

5. The method according to claim 4, further comprising the administration of at least 50 mg of vitamin C each day.

6. The method of according to claim 5, further comprising the administration of least 50 mg of Calcium each day.

7. The method according to claim 6, further comprising the administration of not more than 150 mg of vitamin B6 each day.

8. The method according to claim 7, further comprising the administration of not more than 2000 mg of vitamin C each day.

9. The method according to claim 8, further comprising the administration of not more than 2000 mg of Calcium each day.

10. The method according to claim 9, further comprising the administration of at least 50 mg of lysine each day.

11. The method according to claim 10, further comprising the administration of not more than 2000 mg of lysine each day.

12. The method according to claim 11, further comprising the administration of a selective serotonin reuptake inhibitor (SSRI).

13. The method according to claim 12, said selective serotonin reuptake inhibitor (SSRI) comprising Citalopram.

14. The method according to claim 13 further comprising the administration of an effective amount of Phentermine each day.

15. A method according to claim 14 further comprising the administration of an effective amount of Diethylpropion each day.

16. The method according to claim 1, further comprising the step of administering at least one cofactor, selected from the group of cofactors consisting of vitamin B6, vitamin C, Calcium, and Lysine each day.

17. The method according to claim 16, further comprising the step of administering at least one cofactor, selected from the group of cofactors consisting of vitamin B6 in an effective therapeutic range of 2-150 mg per day, vitamin C in an effective therapeutic range of 50-2000 mg per day, Calcium in an effective therapeutic range of 50-2000 mg per day, and Lysine in an effective therapeutic range of 50-2000 mg per day.

18. The method according to claim 17, wherein a combination of more than one cofactor is administered each day.

19. The method according to claim 18, wherein the combination of cofactors is administered daily for at least six days.

20. The method according to claim 19, wherein the combination of cofactors is administered daily, a first half of the specified amounts being administered approximately at a morning meal and the second half of the specified amounts being administered approximately at an evening meal.

21. A method to facilitate weight loss for a patient not suffering from depression, said method comprising:

a. administration of a selective serotonin reuptake inhibitor (SSRI); and

b. administration of 5-Hydroxytryptophan and Tyrosine wherein said SSRI and said 5-Hydroxytryptophan and said Tyrosine are administered in an effective therapeutic range to effectuate said weight loss, said effective therapeutic range comprising;

i. the administration of 10 mg of said SSRI each day for a period of 6 days followed by the administration of a daily dosage of between 10 mg and 80 mg of said SSRI; and

ii. the administration of at least of 50 mg of said 5-hydroxytryptophan each day for said period of 6 days followed by the administration of a daily dosage of between 50 mg and 900 mg of said 5-hydroxytryptophan; and

iii. the administration of at least of 50 mg of said tyrosine each day for said period of 6 days followed by the administration of a daily dosage of between 50 mg and 4000 mg of said tyrosine.

22. The method according to claim 21, said selective serotonin reuptake inhibitor (SSRI) comprising Citalopram.

23. The method according to claim 22 further comprising the administration of an effective amount of Phentermine each day.

24. The method according to claim 23 further comprising the administration of an effective amount of Diethylpropion each day.

25. The method according to claim 21 further comprising the administration of:

a. 2 mg to 150 mg of vitamin B6each day;

b. 50 mg to 2000 mg of vitamin C each day;

c. 50 mg to 2000 mg of calcium each day; and

d. 50 mg to 2000 mg of Lysine each day.