Virtual 4D treatment suite

• US 7,551,717 B2
• Filed: 08/21/2007
• Issued: 06/23/2009
• Est. Priority Date: 08/21/2007
• Status: Active Grant

• Current Assignee: Koninklijke Philips N.V., Wisconsin Alumni Research Foundation (University of Wisconsin System)
• Original Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.), Wisconsin Alumni Research Foundation (University of Wisconsin System)
• Inventors: Tomé, Wolfgang Axel, Ehler, Eric Drew
• Primary Examiner(s): Yun; Jurie
• Application Number:
  US11/894,378
• Publication Number:
  US 20090052623A1
• Time in Patent Office: 672 Days
• Field of Search: 378/65, 378/68, 378/69, 378/95
• US Class Current: 378/65
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61B 5/087 Measuring breath flow
• CPC Class Codes: A61B 5/1135 by monitoring thoracic expansion
• CPC Class Codes: A61B 5/6831 Straps, bands or harnesses
• CPC Class Codes: A61N 5/1031 using a specific method of dose optimization
• CPC Class Codes: A61N 5/1037 taking into account the movement of the target, e.g. 4D-image based planning
• CPC Class Codes: G16H 20/10 relating to drugs or medications, e.g. for ensuring correct administration to patients
• CPC Class Codes: G16H 30/20 for handling medical images, e.g. DICOM, HL7 or PACS
• CPC Class Codes: G16H 40/63 for local operation
• CPC Class Codes: G16H 70/20 relating to practices or guidelines

Abstract

A virtual 4D treatment suite includes a dose calculation module, a gating module, and a dose rate adjustment module. The 4D treatment suite may be used to virtually analyze the impact the motion of a target tissue has on therapy for a particular patient and a proposed treatment plan. For example, for a proposed treatment plan, the dose calculation module may calculate a dose that would be received by a target tissue and an associated dose temporal variation based on an identified movement of the target tissue relative to at least a portion of a treatment field. Based on the calculated expected therapy dose and dose temporal variation, the gating module may determine whether to implement a gating technique for the proposed treatment plan and/or the dose rate adjustment module may determine whether to adjust the dose rate of the proposed treatment plan.

Claims

1. A method comprising:

identifying relative motion between a region of interest of a patient and at least a portion of a treatment field defined by a proposed treatment plan;

calculating an expected therapy dose and an associated temporal variation in the expected therapy dose to be delivered to the region of interest for the proposed treatment plan based on the identified relative motion between the region of interest and the at least the portion of the treatment field; and

determining whether to apply a dose management technique to the proposed treatment plan based on the expected therapy dose and the associated temporal variation in the expected therapy dose.

2. The method of claim 1, wherein the dose management technique comprises at least one of gating or dose rate adjustment.

3. The method of claim 2, further comprising setting a gating window.

4. The method of claim 3, wherein setting the gating window comprises comparing two or more potential gating windows.

5. The method of claim 2, further comprising adjusting a dose rate based on the expected therapy dose and the associated temporal variation in the expected therapy dose.

6. The method of claim 5, wherein adjusting the dose rate comprises comparing two or more potential dose rates.

7. The method of claim 5, further comprising adjusting a dose delivery time based on the expected therapy dose and the associated temporal variation in the expected therapy dose.

8. The method of claim 7, wherein adjusting the dose rate comprises decreasing the dose rate and adjusting the dose delivery time comprises increasing the dose delivery time.

9. The method of claim 1, further comprising generating the treatment plan based on a 4D image data set of the region of interest of the patient.

10. The method of claim 1, wherein the treatment plan comprises a dose to be delivered to the patient.

11. The method of claim 1, wherein the region of interest comprises at least one of a target tissue or a critical structure.

12. The method of claim 1, wherein identifying the relative motion between the region of interest and the at least the portion of the treatment field comprises identifying a movement of the region of interest throughout a breathing cycle of the patient.

13. The method of claim 1, wherein identifying relative motion between the region of interest and the at least the portion of the treatment field comprises obtaining an image data set of the patient.

14. The method of claim 1, wherein the treatment field comprises a radiation treatment field.

15. A system comprising:

a dose calculation module that calculates an expected therapy dose and an associated temporal variation in the expected therapy dose to be delivered to a region of interest for a proposed radiation therapy treatment plan for a patient based on an identified relative motion between the region of interest and at least a portion of a treatment field; and

a dose management module that determines whether to implement a dose management technique based on the expected therapy dose and the associated temporal variation in the expected therapy dose.

16. The system of claim 15, further comprising a treatment planning system that generates the proposed treatment plan, wherein the region of interest and the treatment field are based on the treatment plan.

17. The system of claim 15, wherein the system further comprises a database including at least one of the treatment plan, breathing data of the patient, 4D image data of the region of interest, patient data or dosimetric constraint rules.

18. The system of claim 15, wherein the dose management module comprises a gating module that selects a gating window for the treatment plan based on the identified relative motion between the region of interest and the at least a portion of the treatment field, wherein the dose calculation module determines the expected therapy dose and the associated temporal variation in the expected therapy dose based on the gating window.

19. The system of claim 18, further comprising a user interface, wherein the gating module selects a gating window for the treatment plan based on user input received via the user interface.

20. The system of claim 15, wherein the dose management module comprises a dose rate adjustment module that adjusts a dose rate of the treatment plan based on the identified relative motion between the region of interest and the at least a portion of the treatment field.

21. The system of claim 20, wherein the expected therapy dose comprises a first expected therapy dose, and wherein the dose calculation module determines a second expected therapy dose and an associated temporal variation in the second expected therapy dose based on the adjusted dose rate.

22. The system of claim 15, further comprising a processor that identifies the relative motion between the region of interest and the at least a portion of a treatment field throughout a breathing cycle of the patient.

23. A computer-readable medium comprising instructions for causing a programmable processor to:

identify relative motion between a region of interest and at least a portion of a treatment field defined by a proposed treatment plan;

calculate an expected therapy dose and an associated temporal variation in the expected therapy dose to be delivered to the region of interest for the proposed treatment plan based on the identified relative motion between the region of interest and the at least the portion of the treatment field; and

determine whether to apply a dose management technique to the proposed treatment plan based on the expected therapy dose and the associated temporal variation in the expected therapy dose.

24. The computer-readable medium of claim 23, wherein the dose management technique comprises at least one of gating or dose rate adjustment.

25. A system comprising:

means for identifying relative motion between a region of interest of a patient and at least a portion of a treatment field defined by a proposed treatment plan;

means for calculating an expected therapy dose and an associated temporal variation in the expected therapy dose to be delivered to the region of interest for the proposed treatment plan based on the identified relative motion between the region of interest and the at least the portion of the treatment field; and

means for determining whether to apply a dose management technique to the proposed treatment plan based on the expected therapy dose and the associated temporal variation in the expected therapy dose.

26. The system of claim 25, wherein the dose management technique comprises at least one of gating or dose rate adjustment.