Compositions and methods for nutrition supplementation

• US 7,560,123 B2
• Filed: 08/12/2004
• Issued: 07/14/2009
• Est. Priority Date: 08/12/2004
• Status: Active Grant

• Current Assignee: Exeltis USA, Inc. (Chemo Iberica, S.A.)
• Original Assignee: Everett Laboratories Incorporated (Chemo Iberica, S.A.)
• Inventors: Giordano, John A., Balzer, Charles J.
• Primary Examiner(s): Foley; Shanon A
• Application Number:
  US10/916,534
• Publication Number:
  US 20060034912A1
• Time in Patent Office: 1,797 Days
• Field of Search: 424/439, 424/474, 424/464
• US Class Current: 424/614
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/015 carbocyclic
• CPC Class Codes: A61K 31/07 Retinol compounds, e.g. vitamin A retinoic acids A61K31/203
• CPC Class Codes: A61K 31/355 Tocopherols, e.g. vitamin E
• CPC Class Codes: A61K 31/375 Ascorbic acid, i.e. vitamin C; Salts thereof
• CPC Class Codes: A61K 31/4406 only substituted in position 3, e.g. zimeldine nicotinic acid A61K31/455
• CPC Class Codes: A61K 31/4415 Pyridoxine, i.e. Vitamin B6 pyridoxal phosphate A61K31/675
• CPC Class Codes: A61K 31/455 Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
• CPC Class Codes: A61K 31/51 Thiamines, e.g. vitamin B1
• CPC Class Codes: A61K 31/519 ortho- or peri-condensed with heterocyclic rings
• CPC Class Codes: A61K 31/525 Isoalloxazines, e.g. riboflavins, vitamin B2
• CPC Class Codes: A61K 31/593 9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
• CPC Class Codes: A61K 31/714 Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
• CPC Class Codes: A61K 31/715 Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
• CPC Class Codes: A61K 33/06 Aluminium, calcium or magnesium; Compounds thereof , e.g. clay
• CPC Class Codes: A61K 33/08 Oxides; Hydroxides
• CPC Class Codes: A61K 33/26 Iron; Compounds thereof
• CPC Class Codes: A61K 33/30 Zinc; Compounds thereof
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 47/34 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers A61K47/10 takes precedence
• CPC Class Codes: A61K 9/0053 : Mouth and digestive tract, i.e. intraoral and peroral administration rectal administration A61K9/0031
• CPC Class Codes: A61K 9/0056 : Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
• CPC Class Codes: A61P 3/02 : Nutrients, e.g. vitamins, minerals

Abstract

The present invention relates to compositions that may be swallowable, chewable or dissolvable, comprising various vitamins and minerals, and in a specific embodiment comprising vitamin A, beta carotene, B-complex vitamins, vitamin C, vitamin D₃, vitamin E, iron, magnesium and zinc, and methods for using these compositions for nutritional supplementation in subjects undergoing physiologically stressful events, such as, for example and without limitation, pregnancy, lactation or any disease state.

Claims

1. A composition consisting of vitamin A, beta carotene, vitamin B₁, vitamin B₂, vitamin B₃, vitamin B₆, vitamin B₉, vitamin B₁₂, vitamin C, vitamin D₃, vitamin E, iron, magnesium, zinc and one or more pharmaceutically acceptable carriers.

2. The composition of claim 1 wherein said vitamin A is present in an amount of about 550 IU to about 1650 IU;

said beta carotene is present in an amount of about 300 IU to about 900 IU;

said vitamin B₁ is present in an amount of about 1 mg to about 3 mg;

said vitamin B₂ is present in an amount of about 1 mg to about 3 mg;

said vitamin B₃ is present in an amount of about 7 mg to about 23 mg;

said vitamin B₆ is present in an amount of about 1 mg to about 4 mg;

said vitamin B₉ is present in an amount of about 500 μ

g to about 1500 μ

g;

said vitamin B₁₂ is present in an amount of about 2 μ

g to about 8 μ

g;

said vitamin C is present in an amount of about 30 mg to about 90 mg;

said vitamin D₃ is present in an amount of about 200 IU to about 600 IU;

said vitamin E is present in an amount of about 15 IU to about 45 IU;

said iron is present in an amount of about 14 mg to about 44 mg;

said magnesium is present in an amount of about 12 mg to about 38 mg; and

said zinc is present in an amount of about 7 mg to about 23 mg.

3. The composition of claim 1 wherein said vitamin A is present in an amount of about 1100 IU;

said beta carotene is present in an amount of about 600 IU;

said vitamin B₁ is present in an amount of about 1.6 mg;

said vitamin B2 is present in an amount of about 1.8 mg;

said vitamin B₃ is present in an amount of about 15 mg;

said vitamin B₆ is present in an amount of about 2.5 mg;

said vitamin B₉ is present in an amount of about 1000 μ

g;

said vitamin B₁₂ is present in an amount of about 5 μ

g;

said vitamin C is present in an amount of about 60 mg;

said vitamin D₃ present in an amount of about 400 IU;

said vitamin E is present in an amount of about 30 IU;

said iron is present in an amount of about 29 mg;

said magnesium is present in an amount of about 25 mg; and

said zinc is present in an amount of about 15 mg.

4. A method consisting of administering to a patient the composition of claim 1.

5. The method of claim 4 wherein said vitamin A is present in an amount of about 550 IU to about 1650 IU;

said beta carotene is present in an amount of about 300 IU to about 900 IU;

said vitamin B₁ is present in an amount of about 1 mg to about 3 mg;

said vitamin B₂ is present in an amount of about 1 mg to about 3 mg;

said vitamin B₃ is present in an amount of about 7 mg to about 23 mg;

said vitamin B₆ is present in an amount of about 1 mg to about 4 mg;

said vitamin B₉ is present in an amount of about 500 μ

g to about 1500 μ

g;

said vitamin B₁₂ is present in an amount of about 2 μ

g to about 8 μ

g;

said vitamin C is present in an amount of about 30 mg to about 90 mg;

said vitamin D₃ is present in an amount of about 200 IU to about 600 IU;

said vitamin E is present in an amount of about 15 IU to about 45 IU;

said iron is present in an amount of about 14 mg to about 44 mg;

said magnesium is present in an amount of about 12 mg to about 38 mg; and

said zinc is present in an amount of about 7 mg to about 23 mg.

6. The method of claim 4 wherein said vitamin A is present in an amount of about 1100 IU;

said beta carotene is present in an amount of about 600 IU;

said vitamin B₁ is present in an amount of about 1.6 mg;

said vitamin B₂ is present in an amount of about 1.8 mg;

said vitamin B₃ is present in an amount of about 15 mg;

said vitamin B₆ is present in an amount of about 2.5 mg;

said vitamin B9 is present in an amount of about 1000 μ

g;

said vitamin B₁₂ is present in an amount of about 5 μ

g;

said vitamin C is present in an amount of about 60 mg;

said vitamin D₃ is present in an amount of about 400 IU;

said vitamin E is present in an amount of about 30 IU;

said iron is present in an amount of about 29 mg;

said magnesium is present in an amount of about 25 mg and said zinc is present in an amount of about 15 mg.