Use of periodicity in medical data analysis

• US 7,561,912 B2
• Filed: 09/19/2005
• Issued: 07/14/2009
• Est. Priority Date: 09/19/2005
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Schatz, Kelly, Sweeney, Robert J.
• Primary Examiner(s): Layno; Carl H
• Assistant Examiner(s): Gedeon; Brian T
• Application Number:
  US11/230,298
• Publication Number:
  US 20070067005A1
• Time in Patent Office: 1,394 Days
• Field of Search: 600/509, 600/513, 600/515
• US Class Current: 600/509
• CPC Class Codes: A61N 1/37 Monitoring; Protecting
• CPC Class Codes: A61N 1/37211 Means for communicating with stimulators

Abstract

A patient management system is described that includes an implantable device for collecting one or more physiological parameter values and associated timestamps indicating the time at which the value is collected. The system is then configured to determine the periodic variation, if any, of a particular physiological parameter and use that periodicity in assessing changes in the parameter values over time.

Claims

1. A patient management system, comprising:

a medical data management device configured to collect values of one or more physiological parameters along with associated timestamps indicative of the times at which the parameter values were measured;

an implantable medical device that includes one or more sensing modalities for measuring values one or more physiological parameters and circuitry for collecting and communicating the parameter values to the medical data management device along with associated timestamps indicative of the times at which the parameter values were measured; and

,

wherein the medical data management device is further configured to use the timestamps associated with the collected parameter values of a physiological parameter to measure the periodic variation, if any, of that particular physiological parameter, and wherein the periodic variation of a physiological parameter is determined by computing an autocorrelation function of a time series of collected parameter values.

2. The system of claim 1 wherein the physiological parameter values and associated timestamps collected by the medical data management device include one or more parameter values and timestamps as communicated to the medical management device via wireless telemetry.

3. The system of claim 2 wherein the one or more externally communicated physiological parameters includes blood pressure.

4. The system of claim 2 wherein the one or more externally communicated physiological parameters includes body weight.

5. The system of claim 2 wherein the one or more externally communicated physiological parameters includes the occurrence of a medication dose.

6. The system of claim 2 wherein the implantable medical device further comprises telemetry circuitry that communicates measured parameter values to a monitoring device via a wireless telemetry link and wherein the monitoring device relays the parameter values measured by the implantable medical device and externally communicated parameter values to the medical data management device via a network connection.

7. The system of claim 1 wherein the medical data management device is further configured to identify the period or periods at which the parameter varies as the lag value at which the autocorrelation function exhibits a peak.

8. The system of claim 1 wherein the physiological parameter values represent values of the parameter averaged over a specified period of time.

9. The system of claim 1 wherein the medical data management device is further configured to compare a present value of a parameter with a previous value of the parameter in a manner which takes into account the periodic variation of the parameter.

10. The system of claim 9 wherein the present value of the parameter represents the values of the parameter averaged over a first period of time and wherein the previous value of the parameter represents the values of the parameter averaged over a second period of time, the previous value of the parameter being regarded as a baseline value.

11. The system of claim 9 wherein the medical data management device is configured to set an alarm if the difference between the present and previous values of one or more parameters exceeds a specified threshold a specified number of times or over a specified period of time.

12. The system of claim 9 wherein the medical data management device is further configured to compute a health status parameter as a function of the differences between the present and past values of one or more physiological parameters.

13. The system of claim 9 wherein the medical data management device is further configured to compute the conditional probability of an adverse health event as a function of the differences between the present and past values of one or more physiological parameters.

14. The system of claim 1 wherein the medical data management device is further configured to compare a present value of a parameter with a previous value of the parameter measured at a time such that the time interval between the measurement times of the present and previous parameter values is equal to a period of the periodic variation of the parameter.

15. The system of claim 14 wherein the medical data management device is further configured to compare a present value of a parameter with a previous value of the parameter, wherein the present and previous values of the parameter are measured at a similar time of day, day of the week, or day of the month in accordance with whether the periodic variation of the parameter is daily, weekly, or monthly, respectively.

16. The system of claim 1 wherein the medical data management device is further configured to identify parameters with similar periodic variations.

17. The system of claim 1 wherein the medical data management device is further configured to use the collected values of a physiological parameter to periodically re-determine the periodic variation of that parameter.

18. The system of claim 17 wherein the medical data management device is further configured to set an alarm if the periodic variation of a particular physiological parameter changes by a specified threshold amount.

19. The system of claim 1 wherein the one or more physiological parameters measured by the implantable medical device includes heart rate.

20. The system of claim 1 wherein the one or more physiological parameters measured by the implantable medical device includes an estimate of heart rate variability.

21. The system of claim 1 wherein the one or more physiological parameters measured by the implantable medical device includes activity level.

22. The system of claim 1 wherein the one or more physiological parameters measured by the implantable medical device includes minute ventilation.

23. The system of claim 1 wherein the one or more physiological parameters measured by the implantable medical device includes an estimate of cardiac output.

24. The system of claim 1 wherein the implantable medical device further comprises telemetry circuitry that communicates measured parameter values to the medical data management device via a wireless telemetry link.

25. The system of claim 1 wherein the implantable medical device further comprises a programmable controller and wherein the medical data management device is implemented as code executed by the controller.

26. The system of claim 1 wherein the medical data management device is further configured to compute a trend in the values of a physiological parameter that are measured at a similar time of day, day of the week, or day of the month in accordance with whether the periodic variation of the parameter is daily, weekly, or monthly, respectively.