Methods of treatment using anti-ErbB antibody-maytansinoid conjugates

  • US 7,575,748 B1
  • Filed: 07/17/2006
  • Issued: 08/18/2009
  • Est. Priority Date: 03/16/2000
  • Status: Expired due to Term
First Claim
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1. A method for the treatment of a tumor in a mammal, comprising the steps of (i) identifying said tumor as being characterized by overexpression of an ErbB2 receptor and as being a tumor that does not respond, or responds poorly, to treatment with an anti-ErbB antibody, and (ii) intravenously administering to the mammal a therapeutically effective amount of a conjugate of a humanized antibody huMab 4D5-8 covalently linked via a thioether linking group with a maytansinoid DM1 having the structure

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