Heterocyclic compounds useful in treating diseases and conditions

• US 7,582,643 B2
• Filed: 02/18/2008
• Issued: 09/01/2009
• Est. Priority Date: 02/26/2007
• Status: Expired due to Fees

• Current Assignee: Pfizer Inc.
• Original Assignee: Pfizer Inc.
• Inventors: Turner, Steven R., Trujillo, John I., Kiefer, James R. Jr., Pelc, Matthew J., Moon, Joseph B., Blake, Tanisha D., Schweitzer, Barbara A., Olson, Kirk L., Neal, Bradley E., Hamper, Bruce C., Huang, Wei, Thorarensen, Atli
• Primary Examiner(s): Andres; Janet L
• Assistant Examiner(s): Robinson; Binta M
• Application Number:
  US12/032,723
• Publication Number:
  US 20080207651A1
• Time in Patent Office: 561 Days
• Field of Search: 544/333, 544/253, 514/332, 514/264.11
• US Class Current: 514/264.11
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 11/02 Nasal agents, e.g. decongestants
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 17/04 Antipruritics
• CPC Class Codes: A61P 27/14 Decongestants or antiallergics
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 37/08 Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07D 401/02 containing two hetero rings
• CPC Class Codes: C07D 401/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 401/14 containing three or more hetero rings
• CPC Class Codes: C07D 413/14 containing three or more hetero rings
• CPC Class Codes: C07D 417/14 containing three or more hetero rings
• CPC Class Codes: C07D 471/04 Ortho-condensed systems

Abstract

The present invention relates to compounds of formula (I)

and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are as defined herein, compositions containing such compounds and the uses of such compounds for the treatment of various diseases and conditions such as asthma.

Claims

1. A compound which is:

2-(3-fluorophenyl)-N-[1-(6-methyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)pyrrolidin-3-yl]pyrimidine-5-carboxamide;

or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising a compound of claim 1 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

3. A method of treating allergy or allergic inflammation in a subject, the method comprising administering to the subject in need thereof a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof.

4. A method of treating asthma in a subject, the method comprising administering to the subject in need thereof a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof.

5. A pharmaceutical composition comprising a compound of claim 1, or a pharmaceutically acceptable salt thereof, and a second pharmacologically active compound.