Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease

  • US 7,582,786 B2
  • Filed: 02/23/2006
  • Issued: 09/01/2009
  • Est. Priority Date: 12/07/1992
  • Status: Expired due to Fees
First Claim
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1. A salen-metal compound having antioxidant activity and having a structural formula of Structure XXIII or Structure XXIV as shown in FIG. 26E, wherein:

  • M is selected from the group consisting of Mn, Co, Fe, V, and Cr;

    A is an axial ligand selected from the group consisting of Cl, F, O, Br and acetyl;

    X2, X3 and X4 are independently selected from the group consisting of hydrogen, lower alkoxy, halide and aryloxy;

    Y2, Y3 and Y4 are independently selected from the group consisting of hydrogen, lower alkoxy, halide and aryloxy; and

    R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen, aryl, substituted aryl, heteroatom-bearing aromatic, arylalkyl, lower alkoxy and halide and wherein one of R1 and R2 is optionally covalently linked to one of R3 and R4 thereby forming a cyclic structure.

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