Use of onion extracts to prevent and treat acute and chronic cardiac and vascular complications and their sequelae, as well as to resolve hematomas

• US 7,588,784 B2
• Filed: 10/05/2007
• Issued: 09/15/2009
• Est. Priority Date: 10/05/2007
• Status: Expired due to Fees

• Current Assignee: Attila Mady, Juliana Mady
• Original Assignee: Attila Mady, Juliana Mady
• Inventors: Mady, Attila, Mady, Juliana
• Primary Examiner(s): Flood; Michele
• Assistant Examiner(s): Mi; Qiuwen
• Application Number:
  US11/868,258
• Publication Number:
  US 20090092692A1
• Time in Patent Office: 711 Days
• Field of Search: None
• US Class Current: 424/725
• CPC Class Codes: A61K 36/8962 Allium, e.g. garden onion, leek, garlic or chives

Abstract

Onions (Allium Cepa and its close relatives, as opposed to Allium Sativum) contain potent coagulation modulators, as well as platelet inhibitors. Clinical, in vivo and in vitro testing confirms that the efficacy of commonly consumed quantities of onions in terms of the efficacy of its impact on coagulation and platelet function rivals and in many respects exceeds the potency of any other modalities available today. Additionally, onion compounds have unique effects as described later in this application. The use of onion extracts is thus proposed to prevent and treat acute and chronic cardiac and vascular complications and their sequelae, to prevent and treat thrombosis, to prevent and treat embolization in the setting of thrombosis, various arrhythmias and cardiac abnormalities, as well as to resolve hematomas

Claims

1. A method of treating hematomas comprising the steps of:

providing an extract of onion (Allium cepa); and

topically applying the onion extract to or proximate an area of a hematoma, for transdermal delivery to increase and accelerate hematoma resorption.

2. A method as claimed in claim 1 wherein the step of topically applying is performed at multiple time intervals.

3. A method as claimed in claim 2 wherein the time intervals are approximately 6 hours.

4. A method as claimed in claim 1 wherein the extract is prepared at temperatures no greater than 80 degrees Celsius.

5. A method as claimed in claim 4 wherein the extract is prepared by a method comprising mechanically crushing an onion bulb produce onion juice.

6. A method as claimed in claim 5 wherein the extract is prepared by a method comprising obtaining water soluble components from the onion juice by filtering the onion juice and removing the water soluble components from volatile oils.

7. A method of treating thrombosis or cardiac arrhythmias in a subject in need thereof comprising the step of providing an extract of onion (Allium cepa), and transdermally administering the onion extract to a subject.

8. A method according to claim 7, wherein the step of transdermally administering is performed at multiple time intervals.

9. A method according to claim 8, wherein the extract is prepared at temperatures no greater than 80 degrees Celsius.

10. A method according to claim 9, wherein the extract is prepared by a method comprising mechanically crushing an onion bulb to produce onion juice.

11. A method according to claim 10, wherein the extract is prepared by a method comprising obtaining water soluble components from the onion juice by filtering the onion juice and removing the water soluble components from volatile oils.