Methods for preparing and using implantable substance delivery devices
First Claim
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1. A method for preparing an implantable device for a sustained delivery of a substance within a body of a human or an animal subject, said method comprising the steps of:
- (A) dissolving a blocompatible polymer in a suitable solvent solution to produce a polymer-solvent solution;
(B) adding said substance to said polymer-solvent solution to produce a polymer-solvent solution-substance admixture;
(C) drying said polymer-solvent solution-substance admixture to form a substantially dry mass;
(D) adding a liquid to said mass to cause said mass to soften and;
(E) manipulating said softened mass to a desired shape.
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Abstract
Method for preparing an implantable device for a sustained delivery of a substance within a body of a human or an animal subject, the method including; dissolving a biocompatible polymer in a suitable solvent solution to produce a polymer-solvent solution; adding the substance to the polymer-solvent solution to produce a polymer-solvent solution-substance admixture; drying the polymer-solvent solution-substance admixture to form a substantially dry mass; and one or more of the following three steps:
- (1) adding a second polymer-solvent solution-substance admixture to the dry mass and this second polymer-solvent solution-substance admixture is then allowed to dry; and/or,
- (2) refrigerating the mass; and/or,
- (3) adding a liquid to the mass to cause the mass to soften and thereafter manipulating the softened mass to a desired shape.
22 Citations
62 Claims
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1. A method for preparing an implantable device for a sustained delivery of a substance within a body of a human or an animal subject, said method comprising the steps of:
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(A) dissolving a blocompatible polymer in a suitable solvent solution to produce a polymer-solvent solution; (B) adding said substance to said polymer-solvent solution to produce a polymer-solvent solution-substance admixture; (C) drying said polymer-solvent solution-substance admixture to form a substantially dry mass; (D) adding a liquid to said mass to cause said mass to soften and; (E) manipulating said softened mass to a desired shape. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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33. A method for preparing an implantable device for a sustained delivery of a substance within a body of a human or an animal subject, said method comprising the steps of:
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(A) dissolving a biocompatible polymer in a suitable solvent solution to produce a polymer-solvent solution; (B) adding said substance to said polymer-solvent solution to produce a polymer-solvent solution-substance admixture; (C) drying said polymer-solvent solution-substance admixture (D) adding a second polymer-solvent solution-substance admixture to said air-dried polymer-solvent solution-substance admixture of said step (C) and said second polymer-solvent solution-substance admixture is allowed to dry; wherein said biocompatible polymer is selected from the group consisting of biodegradable-polymers and non-biodegradable polymers. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62)
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Specification