Adjunctive ultrasound processing and display for breast cancer screening

• US 7,597,663 B2
• Filed: 11/27/2002
• Issued: 10/06/2009
• Est. Priority Date: 11/24/2000
• Status: Expired due to Term

• Current Assignee: U-System Inc. (General Electric Company)
• Original Assignee: U-System Inc. (General Electric Company)
• Inventors: Karssemeijier, Nico, Wang, Shih-Ping, Rao, Fangyi, Chin, Donald
• Primary Examiner(s): Casler; Brian
• Assistant Examiner(s): RAMIREZ, JOHN FERNANDO
• Application Number:
  US10/305,936
• Publication Number:
  US 20030212327A1
• Time in Patent Office: 2,505 Days
• Field of Search: 600/437, 600/427, 600/461, 600/431, 600/440, 600/443, 382/128, 382/131, 382/284, 382/294, 382/132, 378/37, 378/63
• US Class Current: 600/437
• CPC Class Codes: A61B 6/463 characterised by displaying multiple images or images and diagnostic data on one display
• CPC Class Codes: A61B 6/502 for diagnosis of breast, i.e. mammography
• CPC Class Codes: A61B 6/5241 combining overlapping images of the same imaging modality, e.g. by stitching
• CPC Class Codes: A61B 6/5247 combining images from an ionising-radiation diagnostic technique and a non-ionising radiation diagnostic technique, e.g. X-ray and ultrasound
• CPC Class Codes: A61B 6/563 involving image data transmission via a network
• CPC Class Codes: A61B 8/0825 for diagnosis of the breast, e.g. mammography
• CPC Class Codes: A61B 8/406 using means for diagnosing suspended breasts
• CPC Class Codes: A61B 8/4281 characterised by sound-transmitting media or devices for coupling the transducer to the tissue
• CPC Class Codes: A61B 8/4405 Device being mounted on a trolley
• CPC Class Codes: A61B 8/463 characterised by displaying multiple images or images and diagnostic data on one display composite display in devices for short-range imaging with acoustic waves G01S7/52074
• CPC Class Codes: A61B 8/464 involving a plurality of displays
• CPC Class Codes: A61B 8/465 adapted to display user selection data, e.g. icons or menus
• CPC Class Codes: A61B 8/466 adapted to display 3D data 3D imaging and stereoscopic displays in devices for short-range imaging with acoustic waves G01S15/8993 and G01S7/52068, respectively; 3D image rendering G06T15/00; manipulating 3D models for computer graphics G06T19/00
• CPC Class Codes: A61B 8/467 characterised by special input means
• CPC Class Codes: A61B 8/5215 involving processing of medical diagnostic data
• CPC Class Codes: A61B 8/5238 for combining image data of patient, e.g. merging several images from different acquisition modes into one image for image registration algorithms G06T7/30
• CPC Class Codes: A61B 8/565 involving data transmission via a network

Abstract

An adjunctive ultrasound mammography system and associated methods are described comprising an adjunctive ultrasound display configured for quick, intuitive, interactive viewing of data derived from volumetric ultrasound scans, the data being displayed near a conventional x-ray mammogram display. Preferred embodiments for navigating among a thick-slice image array, a selected enlarged thick-slice image, and planar ultrasound views are described, including a preferred embodiment in which the planar ultrasound views are updated in real time as a cursor is moved across an active thick-slice image. In one preferred embodiment the thick-slice images are inverted prior to display, with non-breast areas of the image preferably segmented out and reset to dark. The inverted thick-slice images are of more familiar significance to radiologists having years of expertise in analyzing conventional x-ray mammograms. For example, the inverted thick-slice images allow benign features to be more easily dismissed as compared to non-inverted thick-slice images. Preferred embodiments for computing thick-slice image values from the volumetric scan data are also described that emphasize larger mass lesions in the resulting thick-slice images, and that compensate for mass lesions that straddle thick-slice region borders.

Claims

1. A method for acquisition and interactive display of adjunctive ultrasound mammography information in a breast cancer screening environment, comprising:

compressing a breast of a patient along a compression direction by exerting a compressive force;

acquiring a relatively high number of individual ultrasound slice images representative of a sonographic property of substantially an entire volume of the breast by scanning the breast in an automated scanning process with a linear array transducer, the individual ultrasound slices conforming to planes that are generally along the compression direction and being acquired at a respective relatively high number of scan positions spaced apart by less than about 0.75 mm;

computing from said relatively high number of individual ultrasound slice images a plurality of two-dimensional thick-slice images representative of the sonographic property of the breast in respective relatively thick slices thereof greater than about 2 mm and less than about 20 mm in thickness, said respective relatively thick slices conforming to planes that are generally transverse to the compression direction, wherein said plurality of thick-slice ultrasound images is sufficient in number, and said respective relatively thick slices are sufficient in thickness, such that said respective relatively thick slices collectively occupy substantially the entire breast volume;

electronically displaying to a user a thick-slice image array comprising all of said thick-slice ultrasound images, wherein all of said thick-slice ultrasound images are displayed in a simultaneous, side-by-side manner;

receiving a first command from the user that selects a first member of said thick-slice ultrasound image array and a first location thereon;

responsive to said first command, electronically displaying an enlarged thick-slice image view of said selected first member; and

causing to be displayed on said enlarged thick-slice image view a viewable marker at a second location spatially corresponding to a same location in the breast as said first location on said selected first member.

2. The method of claim 1, wherein said first command consists of single-movement input that simultaneously selects said first member and said first location, said single-movement input being selected from the group consisting of:

a mouse point-and-click, a touchscreen stylus point-and-click, a mouse point-and-double-click, and a touchscreen stylus point-and-double-click.

3. The method of claim 1, said thick-slice image array and said enlarged thick-slice image view being displayed on a thick-slice display, further comprising:

receiving cursor movement commands from the user;

moving a cursor position on said thick-slice display responsive to said cursor movement commands to a third location that is either on said enlarged thick-slice image view or on a member of said thick-slice image array;

displaying adjacent to said thick-slice display and concurrently therewith a first planar ultrasound image representing the sonographic property of the breast along a first plane substantially perpendicular to the thick slice corresponding to the thick-slice image underlying said third location;

and updating in real time said first planar ultrasound image according to said third location as said cursor position is moved.

4. The method of claim 3, farther comprising:

displaying adjacent to said first planar ultrasound image and concurrently therewith a second planar ultrasound image representing the sonographic property of the breast along a second plane different than said first plane, said second plane also being substantially perpendicular to the thick slice corresponding to the thick-slice image underlying said third location; and

updating in real time said second planar ultrasound image according to said third location as said cursor position is moved.

5. The method of claim 4, wherein said second plane is orthogonal to said first plane.

6. The method of claim 5, wherein said compression direction is at an angle that corresponds to a standard x-ray mammogram view.

7. The method of claim 1, said thick-slice image array and said enlarged thick-slice image view being displayed on a thick-slice display, further comprising:

receiving an inversion command from the user;

responsive to said inversion command, displaying an inverted version of said thick-slice display having an ultrasound brightness convention substantially opposite an ultrasound brightness convention of said thick-slice display.

8. The method of claim 1, wherein said number of thick-slice ultrasound images in said thick-slice image array is between about 4 and 16.

9. The method of claim 1, further comprising, while all of said thick-slice ultrasound images of said thick-slice image array are displayed in said simultaneous, side-by-side manner:

receiving a second command from the user that selects a second member of said thick-slice ultrasound image array and a second location thereon;

displaying on each member of said thick-slice image array other than said second member a projected cursor at a location thereon that corresponds in lateral position to said second location on said second member;

computing, based on said second location and from said relatively high number of individual ultrasound slice images, first and second planar images corresponding to first and second planes in the breast generally perpendicular to each other and generally along said compression direction; and

displaying first and second planar ultrasound images adjacent to and concurrently with said thick-slice image array.

10. The method of claim 9, further comprising, while all of said thick-slice ultrasound images of said thick-slice image array are displayed in said simultaneous, side-by-side manner:

receiving cursor movement commands from the user operative to move said second location progressively across said second member; and

dynamically recomputing and redisplaying said projected cursors and said first and second planar images in real time as said cursor movement commands are received.