Tissue engineered biomimetic hair follicle graft
First Claim
1. A graft comprising (1) a bioabsorbable filament having an exterior surface and a central lumen having an interior wall opening through the exterior surface, wherein the central lumen comprises a hydrophilic interior effective to wick the cells into the filament;
- and (2) cells capable of initiating hair follicle neogenesis comprising epidermal cells and dermal cells disposed within the lumen.
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Abstract
The present invention relates to an improved scaffold which is constructed to mimic the architecture of the native hair follicle. The present invention also relates to the use of specific compositions and methods of manufacture to produce scaffolds that combine biocompatibility with the desired rates of bioabsorption. In another embodiment, the present invention relates to a process for manufacturing a biomimetic hair follicle graft and a method for seeding the graft with cells and implanting the graft into the skin where the growth of a new hair shaft is desired. A further embodiment of the present invention relates to a method for hair multiplication in which cells are multiplied in culture and aliquoted into a multitude of bioabsorbable scaffolds in combination with cultured keratinocytes or other allogenic cells.
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Citations
19 Claims
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1. A graft comprising (1) a bioabsorbable filament having an exterior surface and a central lumen having an interior wall opening through the exterior surface, wherein the central lumen comprises a hydrophilic interior effective to wick the cells into the filament;
- and (2) cells capable of initiating hair follicle neogenesis comprising epidermal cells and dermal cells disposed within the lumen.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A graft comprising (1) a bioabsorbable filament having a central lumen having an interior wall;
- and (2) cells capable of initiating hair follicle neogenesis comprising epidermal cells and dermal cells, wherein the epidermal cells are adjacent to the interior wall of the lumen, and the dermal cells are located within the lumen.
Specification