Antimicrobial flush solutions

• US 7,601,731 B2
• Filed: 06/07/2004
• Issued: 10/13/2009
• Est. Priority Date: 06/06/2003
• Status: Active Grant

• Current Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Inventors: Raad, Issam
• Primary Examiner(s): Kosar; Andrew D
• Application Number:
  US10/862,830
• Publication Number:
  US 20050013836A1
• Time in Patent Office: 1,954 Days
• Field of Search: None
• US Class Current: 514/279
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 31/02 Acyclic compounds
• CPC Class Codes: A01N 37/44 containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
• CPC Class Codes: A01N 43/54 1,3-Diazines; Hydrogenated 1,3-diazines
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61L 2/18 Liquid substances or solutions comprising solids or dissolved gases
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 29/14 Materials characterised by their function or physical properties , e.g. lubricating compositions
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence

Abstract

The present invention provides antimicrobial solutions that comprise at least one alcohol, at least one antimicrobial agent and at least one chelator and/or anticoagulant. Also provided are methods for rapidly reducing a microbe or a virus from surfaces including surfaces of indwelling medical devices and organic surfaces such as skin and sutures, and inorganic surfaces such as hospital equipment, pipelines etc.

Claims

1. An antimicrobial solution comprising ethanol, EDTA and either minocycline or trimethoprim, wherein the concentration of ethanol is in the range of 10% to 45% (v/v), the ethanol, EDTA and minocycline or trimethoprim being present in amounts effective to eradicate Candida parapsilosis or methicillin resistant S. aureas embedded in a biofilm.

2. The solution of claim 1, wherein the concentration of the ethanol is in the range of 10-40%.

3. The solution of claim 2, wherein the concentration of ethanol is in the range of 15-30%.

4. The solution of claim 3, wherein the concentration of the ethanol is about 25%.

5. The solution of claim 1, comprising ethanol, minocycline and EDTA.

6. The antimicrobial solution of claim 1, wherein said solution is defined as comprising ethanol, trimethoprim or minocycline, Ca(II)-EDTA, and propylene glycol in a physiologically acceptable saline solution.

7. The antimicrobial solution of claim 1, wherein the solution comprises trimethoprim.

8. The antimicrobial solution of claim 7, further comprising propylene glycol.

9. A syringe, comprising a unit dose of a pharmacologically effective amount of a solution in accordance with any one of claims 1, 2-4, 5, 7 or 8.

10. A vial, comprising a unit dose of a pharmacologically effective amount of a solution in accordance with any one of claims 1, 2-4, 5 or 7-6.

11. A medical device locking solution comprising a solution in accordance with any one of claims 1, 2-4, 5 or 7.